SCI REP:无症状轻度和中度颈动脉狭窄患者主要不良心血管事件的风险!

2018-03-17 xing.T MedSci原创

由此可见,无症状轻度CAS患者MACE的累积风险与无症状中度CAS患者相似。

近日,Scientific reports杂志上发表了一篇研究文章,该研究旨在检验无症状轻度和中度颈动脉狭窄(CAS)患者主要不良心血管事件(MACE)风险相似的假设。

研究人员共招募了453名在2008年1月和2010年12月之间采用多普勒超声(DUS)检查进行基线筛查时发现的无症状CAS患者(30–69%)。在随访8年后,研究人员比较了轻度(30–49%)和中度(50–69%)CAS患者随访时DUS发现和MACE发生率(致死或非致死性心肌梗死卒中和全因死亡率)。

研究人员发现MACE发生在轻度(n=289)和中度(n=164)CAS患者组间的差异无显著性(分别为13.8% vs. 15.9%,P=0.56),虽然在中度CAS患者中同侧卒中风险增加趋势并不显著(1.4% vs. 4.3%;P=0.06)。多元回归分析表明,CAS恶化与MACE发生独立相关(风险比[HR]为4.40;95%可信区间[CI]为2.65-7.27;P<0.01),而增加的血清高密度脂蛋白胆固醇水平与风险降低相关(HR为0.42;95%CI为0.23-0.75;P<0.01)。

由此可见,无症状轻度CAS患者MACE的累积风险与无症状中度CAS患者相似。

原始出处:

Hyunwook Kwon,et al. Risk of major adverse cardiovascular events in subjects with asymptomatic mild carotid artery stenosis.Scientific reports.2018. https://www.nature.com/articles/s41598-018-23125-8

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