Diabetic Med:2型糖尿病和阻塞性睡眠呼吸暂停患者的动脉僵硬度如何?

2018-11-16 MedSci MedSci原创

与没有阻塞性睡眠呼吸暂停的2型糖尿病患者相比,有阻塞性睡眠呼吸暂停并发症的2型糖尿病患者是否会出现动脉僵硬度增加?近日,国际杂志 《Diabetic Med》上在线发表一项关于2型糖尿病和阻塞性睡眠呼吸暂停患者的动脉僵硬度的研究。在一项采用病例对照设计的研究中,研究了40名患有2型糖尿病且未接受治疗的中度至重度阻塞性睡眠呼吸暂停(呼吸暂停 - 呼吸暂停指数≥15)和对照组31名患有2型糖尿病且没有

与没有阻塞性睡眠呼吸暂停的2型糖尿病患者相比,有阻塞性睡眠呼吸暂停并发症的2型糖尿病患者是否会出现动脉僵硬度增加?近日,国际杂志 《Diabetic Med》上在线发表一项关于2型糖尿病和阻塞性睡眠呼吸暂停患者的动脉僵硬度的研究。
在一项采用病例对照设计的研究中,研究了40名患有2型糖尿病且未接受治疗的中度至重度阻塞性睡眠呼吸暂停(呼吸暂停 - 呼吸暂停指数≥15)和对照组31名患有2型糖尿病且没有阻塞性睡眠呼吸暂停的患者(检查呼吸暂停 - 呼吸不足指数<5)。使用ApneaLink® +家庭监控设备(瑞思迈公司,圣地亚哥,CA,USA)提供呼吸暂停低通气指数得分对阻塞性睡眠呼吸暂停状况进行评估。动脉硬化是根据使用Sphygmocor装置和示波美孚-O-格拉夫颈股脉搏波速度®(IEM GmbH公司施托尔贝格,德国)进行评估。
阻塞性睡眠呼吸暂停的2型糖尿病患者和无阻塞性睡眠呼吸暂停患者的颈动脉 - 股动脉脉搏波速度无显著差异(10.7±2.2 m/s vs 10.3±2.1 m/s; P = 0.513),而阻塞性睡眠呼吸暂停的2型糖尿病患者的示波脉搏波的速度显著高于没有阻塞性睡眠呼吸暂停的患者(9.5±1.0 m / s vs 8.6±1.4 m / s; P = 0.002)。在多元回归分析中,年龄(P = 0.002),性别(男性; P = 0.018)和HbA 1c(P = 0.027)与颈动脉 - 股动脉脉搏波速度相关,收缩压(P = 0.004)和年龄(P<0.001)与示波脉搏波速度有关。校正后,阻塞性睡眠呼吸暂停的存在与脉搏波速度无关,无论是通过眼压计还是示波法进行评估。
总之,在排除年龄和血压因素后,本研究未发现中度至重度阻塞性睡眠呼吸暂停与非睡眠型2型糖尿病患者的动脉僵硬度之间存在关联。
原始出处:
M. Hvelplund Kristiansen,A. M. Banghøj,E. Laugesen,et al. Arterial stiffness in people with Type 2 diabetes and obstructive sleep apnoea
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    2018-12-22 tomyang96
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createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Sun Nov 18 01:51:00 CST 2018, time=2018-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609319, encodeId=7b2b16093190b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Sun Nov 18 01:51:00 CST 2018, time=2018-11-18, status=1, ipAttribution=)]
    2018-11-20 haige

    在排除年龄和血压因素后,本研究未发现中度至重度阻塞性睡眠呼吸暂停与非睡眠型2型糖尿病患者的动脉僵硬度之间存在关联。

    0

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    2018-11-18 hb2008ye

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