JCEM:胰岛素治疗的2型糖尿病患者甘油三酯水平与血糖控制之间的关系

2018-11-10 xing.T MedSci原创

由此可见,升高的甘油三酯水平与血糖控制不佳密切相关,因此抑制甘油三酯水平可能有助于2型糖尿病患者获得更优化的血糖控制。

血中甘油三酯水平升高会增加糖尿病糖尿病前期的风险。然而,尚不清楚甘油三酯水平升高是否与2型糖尿病患者的血糖控制不佳有关。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在调查胰岛素治疗的2型糖尿病患者甘油三酯水平升高与血糖控制不佳之间的关系。

研究人员招募了20108名2型糖尿病患者,他们接受了足够剂量的胰岛素治疗。这些患者来自2013年中国国家HbA1c监测系统研究,该研究是在中国大陆进行的一项多中心研究。多变量Logistic回归用于评估甘油三酯水平与血糖控制不佳之间的关联。

总体而言,56.0%纳入的研究对象甘油三酯水平升高(≥1.70mmol/ L),HbA1c≥7.0%(53mmol/mol)和≥6.5%(48 mmol / mol)的患病率分别为67.2%和83.4%。与甘油三酯水平<1.70mmol/L的患者相比,甘油三酯水平范围为1.70-2.29、2.30-3.39和≥3.40mmol/L的患者HbA1c≥7.0%的校正后比值比分别为1.06(0.98-1.15)、1.35(1.23-1.48)和3.12(2.76-3.53)。甘油三酯水平与HbA1c≥6.5%之间存在类似的相关性。通过不同亚群之间的亚组分析证实了这种正相关。甘油三酯水平与血糖控制不佳之间也存在强烈的非线性剂量-反应关系。

由此可见,升高的甘油三酯水平与血糖控制不佳密切相关,因此抑制甘油三酯水平可能有助于2型糖尿病患者获得更优化的血糖控制。

原始出处:

Deqiang Zheng,et al.Association Between Triglyceride Level and Glycemic Control Among Insulin-treated Patients With Type 2 Diabetes.J Clin Endocrinol Metab. 2018. https://doi.org/10.1210/jc.2018-01656

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    2019-08-28 achengzhao
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    2019-02-27 baoya
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    2019-10-18 smallant2015
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  5. 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  6. 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  7. 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  8. [GetPortalCommentsPageByObjectIdResponse(id=2063216, encodeId=15a92063216d5, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Wed Aug 28 23:25:00 CST 2019, time=2019-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1750020, encodeId=b3cc1e50020dd, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Mon Nov 12 10:19:03 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352232, encodeId=bcff3522322f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Sun Nov 11 08:52:13 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352219, encodeId=087e352219e9, content=学习一下,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Sun Nov 11 05:53:08 CST 2018, time=2018-11-11, status=1, ipAttribution=)]
    2018-11-12 一个字-牛

    学习了谢谢分享

    0

  9. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Mon Nov 12 10:19:03 CST 2018, time=2018-11-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352232, encodeId=bcff3522322f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Sun Nov 11 08:52:13 CST 2018, time=2018-11-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352219, encodeId=087e352219e9, content=学习一下,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Sun Nov 11 05:53:08 CST 2018, time=2018-11-11, status=1, ipAttribution=)]
    2018-11-11 衣带渐宽

    学习

    0

  10. 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objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Sun Nov 11 05:53:08 CST 2018, time=2018-11-11, status=1, ipAttribution=)]
    2018-11-11 ren1mw

    学习一下,谢谢分享

    0

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