Hypertension:动态血压与血锰和尿锰之间的关系

2020-03-02 xing.T MedSci原创

总之,在24小时内和白天舒张压与pMn之间存在正相关,在夜间,收缩压与uMn之间存在正相关。

血压(BP)与锰(人体健康所必需的微量元素)之间的关系尚不明确。

近日,心血管权威杂志Hypertension上发表了一篇研究文章,在734名随机招募的瑞士参与者(平均年龄为47.5岁;女性51.4%)中,研究人员评估了动态血压与2种生物标志物,血浆锰(pMn)和尿锰(uMn)排泄之间的相关性。考虑到昼夜波动差异,研究人员使用分装的尿液样本评估了24小时内、觉醒和睡眠期间BP与uMn之间的关系。

受试者24小时、白天和晚上的收缩压/舒张压分别为119.8/78.1、123.8/81.2和107.0/68.3 mmHg;uMn相应的中位数为199.5、83.0和51.5μmol,pMn中位数为0.52μg/L。在根据标志物中位数进行二分法的分析中,较高的pMn与较高的24小时收缩压/舒张压(+4.1/+2.3 mmHg;P≤0.0003)相关,较高的白天uMn和较低的白天BP(-3.5/-1.9mmHg;P≤0.0067)相关,夜间uMn越高,夜间血压越高(+2.9/+1.2mmHg;P≤0.046)。在多变量调整分析中,对于24小时和白天舒张压与pMn呈正相关,而收缩压与夜间uMn相关(P≤0.030)。生物标志物增加2倍与血压之间的相关性大小分别为0.77 mmHg(95%CI为0.08–1.47 mmHg)、0.97(95%CI为0.20–1.76)和1.33(95%CI为0.20–2.50 mmHg) 。

总之,在24小时内和白天舒张压与pMn之间存在正相关,在夜间,收缩压与uMn之间存在正相关。

原始出处:

Zhen-Yu Zhang.et al.Ambulatory Blood Pressure in Relation to Plasma and Urinary Manganese.Hypertension.2020.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.13649

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