Nat Med:肠道细菌或可降低心血管疾病风险

2019-07-02 唐一尘 中国科学报

据《自然—医学》近日在线发表的一项小型临床试验结果,增加特定肠道细菌水平或许可以对超重或肥胖人群产生有益效果。在超重或肥胖人群、患有未经治疗的II型糖尿病或炎症性肠病的人群中,肠道细菌Akkermansia muciniphila水平较低。这项研究认为人体可以安全摄入该细菌,它与健康水平上升相关。

据《自然—医学》近日在线发表的一项小型临床试验结果,增加特定肠道细菌水平或许可以对超重或肥胖人群产生有益效果。在超重或肥胖人群、患有未经治疗的II型糖尿病炎症性肠病的人群中,肠道细菌Akkermansia muciniphila水平较低。这项研究认为人体可以安全摄入该细菌,它与健康水平上升相关。

为解决心血管代谢疾病在全球范围内的演变问题,科学家日益关注靶向肠道微生物群的干预方法。过去基于动物模型的研究表明,A.muciniphila有益健康,比如能够减少肥胖、葡萄糖耐受不良、胰岛素抗性和肝脏脂肪累积。

比利时布鲁塞尔天主教鲁汶大学的Patrice Cani及同事开展了一项概念验证研究,表明活体或经巴氏消毒的A.muciniphila对人体是安全的,而且耐受良好。研究人员表示,总计32名志愿者参与了这项研究,他们在3个月的时间里采用安慰剂或A.muciniphila作为膳食补充剂。研究最终发现与摄入安慰剂者相比,摄入巴氏消毒细菌制剂的被试出现了以下变化:胰岛素敏感度上升,胰岛素水平下降,肠道屏障和血液中的胆固醇水平发生改善。

研究人员总结称,还需要开展进一步的研究确认巴氏消毒A.muciniphila的有益效果是否可以维持3个月以上,并且需要开展规模更大的对照临床试验评估疗效。

原始出处:
Clara Depommier, Amandine Everard, Céline Druart, et al. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nature Medicine. July 2019.

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    2020-05-23 liye789132251
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    2019-07-05 184****9840

    学习了,谢谢分享。

    0

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    2019-07-03 thm112988

    0

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    2019-07-03 深海的鱼

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