JAHA:流感疫苗与高血压患者死亡率的关系

2022-02-10 MedSci原创 MedSci原创

接种流感疫苗与降低高血压患者全因死亡、心血管原因和急性心肌梗塞/卒中的风险显著相关。流感疫苗接种可能会改善高血压患者的预后。

流感感染已被认为是急性心肌梗死和卒中的主要诱因。然而,关于流感疫苗接种对高血压患者死亡率的影响知之甚少。众所周知,在流感感染的急性期,急性心肌梗死和卒中患者死亡的风险会升高。目前尚不清楚接种流感疫苗是否可以降低高血压患者的死亡率。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员进行了一项全国性队列研究,纳入了2007年至2016年期间连续经历了9个流感季节的所有丹麦高血压患者,这些患者至少服用了2种不同类别的抗高血压药物(肾素-血管紧张素系统抑制剂、利尿剂、钙拮抗剂或β-阻滞剂)。研究人员排除了年龄<18岁或者>100岁、患有缺血性心脏病、心力衰竭、慢性阻塞性肺病、癌症或脑血管疾病的患者。

在每个流感季节之前,研究人员评估了流感疫苗的接种情况。该研究的终点定义为全因死亡、心血管原因死亡或卒中或急性心肌梗塞。对于每个流感季节,研究人员从12月1日到次年4月1日对患者进行了随访。

研究人员共纳入了608452名患者。中位随访时间为5个流感季节(四分位距为2-8个流感季节),总随访时间为975902人次每年。在研究季节期间,疫苗覆盖率从26%到36%不等。随访期间,全因死亡21571例(3.5%),心血管原因死亡12270例(2.0%),急性心肌梗塞/卒中死亡3846例(0.6%)。在调整混杂因素后,疫苗接种与降低的全因死亡(HR为0.82;P<0.001)、心血管死亡(HR为0.84;P<0.001)和急性心肌梗塞/卒中死亡(HR为0.90;P=0.017)风险相关。

由此可见,接种流感疫苗与降低高血压患者全因死亡、心血管原因和急性心肌梗塞/卒中的风险显著相关。流感疫苗接种可能会改善高血压患者的预后。

原始出处:

Daniel Modin.et al.Flu Vaccine and Mortality in Hypertension: A Nationwide Cohort Study.JAHA.2022.https://www.ahajournals.org/doi/full/10.1161/JAHA.121.021715

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    2022-02-11 zhaohui6731
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    2022-02-10 ms5000000018187740

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    0

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