2021 USPSTF建议:青少年和成人乙型肝炎病毒感染筛查建议声明

2021-02-05 MedSci原创 MedSci原创

乙型肝炎病毒(Hepatitis B virus)简称乙肝病毒(HBV),是一种DNA病毒,引起乙型肝炎的病原体。目前,HBV感染是全球性的公共卫生问题,随着乙肝疫苗的普及率逐年上升,感染率呈下降趋势

乙型肝炎病毒(Hepatitis B virus)简称乙肝病毒(HBV),是一种DNA病毒,引起乙型肝炎的病原体。目前,HBV感染是全球性的公共卫生问题,随着乙肝疫苗的普及率逐年上升,感染率呈下降趋势。然而,根据CDC调查数据显示,约有68%的慢性乙型肝炎患者没有意识到自己的感染,而且许多患者在肝硬化或终末期肝病发作之前一直无症状。 近日,美国预防服务工作组(USPSTF)根据2014年至2019年8月发布的新的随机临床试验和队列研究进行回顾,对以往建议进行更新,评估了抗病毒治疗的健康结局,以及HBV新的筛查策略和高危人群筛查工具的安全性和准确性。 风险评估 此次更新和扩展先前对高风险人群进行HBV感染筛查范围,USPSTF建议在感染风险较高的青少年和成年人中进行筛查HBV感染,包括已接种疫苗的人群。美国疾病预防控制中心和美国肝病研究协会都建议对需要免疫抑制治疗,透析前,血液透析,腹膜透析或家庭透析的患者进行筛查。 同时,USPSTF对孕妇筛查提出了不同的意见。生活在美国的非美国出生者的HBV感染风险因原籍国不同而有很大差异。出生在乙型肝炎表面抗原(HBsAg)流行率为2%或更高的国家

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    2021-08-20 黄金霞

    好文章,重视乙肝,

    0

  4. 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    2021-08-07 ms6000000055605696

    重视乙肝筛查,值得学习

    0

  5. 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  6. 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time=2021-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351574, encodeId=726213515e43b, content=<a href='/topic/show?id=74672339e92' target=_blank style='color:#2F92EE;'>#乙型肝炎病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23397, encryptionId=74672339e92, topicName=乙型肝炎病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Feb 07 13:59:13 CST 2021, time=2021-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537038, encodeId=bfb1153e0388b, content=<a href='/topic/show?id=7b6e18196cf' target=_blank style='color:#2F92EE;'>#USPSTF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18196, encryptionId=7b6e18196cf, topicName=USPSTF)], attachment=null, 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authenticateStatus=null, createdAvatar=, createdBy=39345225392, createdName=1478bfb4m38(暂无昵称), createdTime=Sat Feb 06 12:56:05 CST 2021, time=2021-02-06, status=1, ipAttribution=)]
    2021-02-16 1e1fd1c9m05(暂无匿称)

    好文章

    0

  7. 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  8. 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authenticateStatus=null, createdAvatar=, createdBy=39345225392, createdName=1478bfb4m38(暂无昵称), createdTime=Sat Feb 06 12:56:05 CST 2021, time=2021-02-06, status=1, ipAttribution=)]
    2021-02-07 lingqf
  9. 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    2021-02-07 Jessica

    约有68%的慢性乙型肝炎患者没有意识到自己的感染,而且许多患者在肝硬化或终末期肝病发作之前一直无症状。这个有点可怕了,筛查很重要!

    0

  10. 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authenticateStatus=null, createdAvatar=, createdBy=39345225392, createdName=1478bfb4m38(暂无昵称), createdTime=Sat Feb 06 12:56:05 CST 2021, time=2021-02-06, status=1, ipAttribution=)]
    2021-02-06 1478bfb4m38(暂无昵称)

    好文章!

    0

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近日,国际学术期刊plos pathogens在线发表了日本科学家的一项最新研究进展,他们发现在TGFβ对乙型肝炎病毒(HBV)复制的抑制过程依赖于活化诱导胞嘧啶核苷脱氨酶(AID)的表达,AID能够显著抑制HBV转录和病毒DNA合成,最终导致对病毒复制的抑制。 乙型肝炎病毒(HBV)是导致肝细胞癌发生的一个重要诱发因素。最近一些研究发现APOBEC脱氨酶家族成员能够通过抑制病毒复制(如

Anal Biochem:纳米材料用于乙型肝炎病毒 的检测

这项工作描述了使用电化学和光学技术检测乙型肝炎病毒(HBV)基因组DNA的不同方法。该检测方法由对HBV具有特异性的单链DNA探针(HEPB1S)组成,嫁接在还原型氧化石墨烯或金纳米颗粒修饰的金电极上。 差分脉冲伏安法分析表明,当与阴性对照相比时,HBV基因组DNA的添加导致当前峰值增加约1.4倍。与对数HBV-基因组DNA浓度和检测的电化学生物传感器之间存在线性相关性,直到目标为7.65p

IJLH:乙型肝炎病毒(HBG2)、乙型肝炎病毒(BCL11A)和血红蛋白(HMIP)多态性与伊拉克库尔德人镰状细胞病胎儿血红蛋白及临床表型的关系

胎儿血红蛋白(HbF)是镰状细胞病(SCD)严重程度的主要调节因子。HbF主要由2号、6号和11号染色体上的三个主要数量性状位点(QTL)调控。 三个qtl中有5个snp (HBG2, rs7482144;BCL11A, rs1427407, rs10189857;研究人员采用多重PCR和反向杂交技术对HBS1L‐MYB基因间区、rs28384513和rs9399137进行了研究,并评估了它