JAMA Cardiol:小时候“打呼噜”竟然与青春期血压升高有关!

2021-07-04 MedSci原创 MedSci原创

阻塞性睡眠呼吸暂停(OSA)俗称“打呼噜”,是在打呼噜的同时还伴有短暂的憋气,这在人群中十分常见,大约1/3的中年男性和1/5的中年女性都有OSA。

阻塞性睡眠呼吸暂停(OSA)俗称打呼噜,是在打呼噜的同时还伴有短暂的憋气,这在人群中十分常见,大约1/3的中年男性和1/5的中年女性都有OSA。而在高血压和冠心病等慢性病人群中,OSA的比例甚至高达80%打呼噜不仅扰民,也严重危害着机体健康。

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尽管儿科指南已经描述了青年血压升高的更新阈值,OSA是血压升高的既定危险因素,但但儿童 OSA 与青少年血压升高的关系仍未得到探索。近日,发表在JAMA Cardiol杂志的一项研究评估了儿童 OSA 与青少年血压升高之间的关系。

在这项研究中,研究人员基于2000-2005 年宾夕法尼亚州儿童队列研究,随机抽取了 700 5 12 岁儿童。共有421名(60.1%)儿童随访7.4年到青少年,年龄为12-23岁。数据分析是在202076日至1029日进行。

结果显示,在421名青少年中,随访平均年龄为16.5岁,227人(53.9%)为男性,92人(21.9%)为少数种族/民族。自儿童时期以来呼吸暂停低通气指数 (AHI) 评分≥ 2 与青少年时期血压升高有关(几率[OR]2.995%CI 1.1-7.5)。然而, AHI 2 5 与青少年时期血压升高相关性不显著(OR1.595% CI0.9-2.6),而 AHI ≥ 5的相关性约为 2 倍(OR2.395 % CI, 1.1-4.9) ,即使在调整内脏脂肪组织后。在女性参与者中,儿童OSA与青少年血压升高没有关系,而男性参与者中OSA和血压升高的风险更大。

总之,这项队列研究的结果表明,只有当儿童OSA持续存在时,才与青少年高血压有关。内脏脂肪在很大程度上(但不是全部)解释了与青少年OSA相关的高血压风险,这在男性个体中关联度更高。

原始出处

Julio Fernandez-Mendoza, PhD1; Fan He, MS2Susan L. Calhoun, PhD1; et al.Association of Pediatric Obstructive Sleep Apnea With Elevated Blood Pressure and Orthostatic Hypertension in Adolescence.JAMA Cardiol. Published online June 23, 2021. doi:10.1001/jamacardio.2021.2003

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    2021-11-26 zhaojie88
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    2021-07-05 weigq

    ???

    0

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    2021-07-04 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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    2021-07-04 doctor y4213

    有趣

    0

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