Diabetologia:糖尿病和血管病糖化血红蛋白指数和糖尿病相关并发症的风险

2018-05-04 MedSci MedSci原创

近日,国际杂志 《Diabetologia》上在线发表一项关于糖尿病和血管病糖化血红蛋白指数和糖尿病相关并发症的风险--Preterax和达美康改良释放对照评估(ADVANCE)试验的研究。 以前的研究表明,血红蛋白糖化指数(HGI)可以作为1型和2型糖尿病患者糖尿病相关并发症的预测指标。研究人员使用来自糖尿病和血管疾病行动:Preterax和达美康改良释放对照评估(ADVANCE)试验的数

近日,国际杂志 《Diabetologia》上在线发表一项关于糖尿病和血管病糖化血红蛋白指数和糖尿病相关并发症的风险--Preterax和达美康改良释放对照评估(ADVANCE)试验的研究。 以前的研究表明,血红蛋白糖化指数(HGI)可以作为1型和2型糖尿病患者糖尿病相关并发症的预测指标。研究人员使用来自糖尿病和血管疾病行动:Preterax和达美康改良释放对照评估(ADVANCE)试验的数据,研究了HGI是否可以预测重度葡萄糖下降和糖尿病相关并发症的不良结果。 研究人员对ADVANCE试验的参与者进行了基线HbA 1c和空腹血糖(FPG)(n= 11,083)数据的研究。HGI是观察到的HbA 1c和FPG 上HbA 1c的简单线性回归预测的HbA 1c之间的差值。使用Cox回归,研究人员调查了HGI(分类和连续性)与不良结果之间的关联,考虑了治疗分配(强化或标准血糖控制),并比较了HGI和HbA 1c的预测。 强化血糖控制降低了高HGI患者的死亡风险(HR 0.74 [95%CI 0.61,0.91]; P=0.003),而强化治疗对高HbA 1c患者死亡率的影响没有差异。不论治疗

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    2018-11-12 丁鹏鹏
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2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313267, encodeId=5ad631326e43, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue May 08 22:47:33 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313242, encodeId=09d4313242f1, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Tue May 08 21:46:02 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=312473, encodeId=2f3f3124e312, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sun May 06 07:36:52 CST 2018, time=2018-05-06, status=1, ipAttribution=)]
    2018-05-09 易水河

    学习学习.不错

    0

  8. 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createdBy=09431951290, createdName=大爰, createdTime=Tue May 08 21:46:02 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=312473, encodeId=2f3f3124e312, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sun May 06 07:36:52 CST 2018, time=2018-05-06, status=1, ipAttribution=)]
    2018-05-08 惠映实验室

    学习了.谢谢分享.

    0

  9. 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createdBy=09431951290, createdName=大爰, createdTime=Tue May 08 21:46:02 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=312473, encodeId=2f3f3124e312, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sun May 06 07:36:52 CST 2018, time=2018-05-06, status=1, ipAttribution=)]
    2018-05-08 大爰

    学习了谢谢分享!!

    0

  10. 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    2018-05-06 yfjms

    学习

    0

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Radiology:胰腺US回声增强与糖尿病有什么关系吗?

本研究旨在评价胰腺回声增强(IPE)与血糖升高和偶发糖尿病的相关性,并将结果发表在Radiology上。

真实世界研究研究:canagliflozin在2型糖尿病患者中具有比达格列净更好的血糖控制能力

近日,强生公司旗下的杨森制药公司宣布了一项真实世界研究的结果,该研究显示,相比于Farxiga®(达格列净)10mg治疗,基于INVOKANA®(canagliflozin)300mg治疗的成人2型糖尿病患者的血糖。因此使用INVOKANA治疗的患者也不太可能停止治疗或转用另一种药物治疗2型糖尿病。最新发表的研究结果发表在Current Medical Research and Opinion上

Mol Ther:重编程胰腺导管细胞,成功治疗糖尿病小鼠

在糖尿病的发生发展中,胰岛β细胞功能的进行性丧失最终会导致高血糖的恶化和各种并发症的发生。现在,科学家们找到一种治疗1型糖尿病的策略——通过重编程小鼠体内的胰腺导管细胞,成功治疗遗传和化学诱发的糖尿病。

J Clin Invest:新研究揭示胰岛素抵抗与脂肪组织炎症的因果关系

肥胖诱导的胰岛素抵抗是2型糖尿病、高脂血症、心血管疾病和一些癌症类型发生的主要风险因素,肥胖引起胰岛素抵抗的机制到目前为止仍不明确。许多研究表明炎症与局部和系统性胰岛素抵抗的发生有关,特别是当炎症发生在白色脂肪组织当中,但是这些事件的因果关系还不清楚。在最近发表在国际学术期刊JCI上的一项研究中,来自瑞士的研究人员发现脂肪组织的胰岛素抵抗导致了局部炎症的发生,并非炎症导致了脂肪组织的胰岛素抵抗。

降糖治疗临床试验大汇总:哪些药能为糖尿病患者带来更多好处?

从1970年发表的UGDP研究,到新近公布的多项新型降糖药物试验,近40余年来国外学者针对2型糖尿病患者先后完成了多项随机化临床试验。概括的讲,这些研究可以分为两类,即降糖试验与降糖药物试验。