Stroke:大血管闭塞性脑梗死超急性期梗死体积急骤变化的指标有哪些?

2020-03-02 shaosai MedSci原创

大血管闭塞性脑梗死会引发的梗死体积出现急骤的变化。本研究旨在识别与前循环大血管闭塞性脑卒中患者梗死体积急骤增大相关的临床、影像学指标。

背景和目的
血管闭塞性脑梗死会引发的梗死体积出现急骤的变化。本研究旨在识别与前循环大血管闭塞性脑卒中患者梗死体积急骤增大相关的临床、影像学指标。
方法
本研究共纳入了722例急性脑卒中的患者。筛选出前循环大血管闭塞性脑卒中的患者,记录入院时发病时间、CT灌注检查时间进行分析(n=178)。利用自动阈值测量CT灌注检查中缺血性梗死核心体积。梗死核心急骤增大定义为根据发病时间对缺血梗死核心进行分类,对病变由发病到影像学检查体积线性进展作图。关于侧支循环评价,采用局部柔脑膜侧支循环评分(rLMC)进行评价。临床数据包括NIHSS评分和脑血管危险指标。利用回归分析进行统计学分析。
结果
缺血核心体积中位数为34.4 mL,梗死核心急骤增大速度为0.27 mL/min。回归分析纳入了年龄、性别、NIHSS、血凝块负荷评分、糖尿病、吸烟史、高血脂、高血压、ASPECTS和rLMC评分,仅有rLMC与梗死体积急骤增大具有相关性(adjusted β=-0.35; P<0.001)。根据rLMC评分对患者采用三分法进行分类,良好、一般和较差侧支循环功能的患者分别有65 例(rLMC >15)、67 例(rLMC 11-15) 和46 例(rLMC <11),其梗死核心急骤增大速度分别为0.17 mL/min、0.26 mL/min、0.41 mL/min。
结论
梗死核心急骤增大速度与侧支循环功能密切相关。在脑卒中中心,可以根据梗死核心增大速度评估患者在转运中的梗死体积变化,从而有助于决策治疗。
原始出处:
Puhr-Westerheide D, Tiedt S, Rotkopf LT, et al,Clinical and Imaging Parameters Associated With Hyperacute Infarction Growth in Large Vessel Occlusion Stroke.Stroke. 2019.DOI:10.1161/STROKEAHA.119.025809
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    2020-12-28 feifers
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    2020-07-11 kkunny
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    2020-03-04 karmond

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