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EUR HEART J-CARD PHA：全国登记资料的回顾性分析心肌梗死患者出血后的抗血栓治疗和主要不良心脏事件

2020-02-04 MedSci MedSci原创

抗血栓治疗心脏
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本研究的目的是描述心肌梗死(MI)患者在发生出血事件后使用抗血栓治疗，以及发生重大心脏不良事件(MACE)的相关风险。

本研究的目的是描述心肌梗死(MI)患者在发生出血事件后使用抗血栓治疗，以及发生重大心脏不良事件(MACE)的相关风险。

利用丹麦全国的登记，追踪并确定在心肌梗死后1年内因出血事件住院的患者。出血时、出血后90天和180天采用阿司匹林、氯吡格雷和/或维生素K拮抗剂(VKA)的抗血栓治疗。根据指南，患者被分为四组:预期、减少、停用或加强治疗组。Cox比例危险模型评估了第一年的MACE(缺血性中风、心肌梗死或死亡)风险。本研究共纳入心肌梗死后出血患者3324例。出血后第90天，1052例(31.7%)接受预期的抗血栓治疗，1301例(39.2%)减少，164例(4.9%)加强，807例(24.3%)未接受治疗。研究结果显示637例(19.2%)发生重大心脏不良事件。以双抗血小板治疗为参照，调整后的MACE危险比为：阿司匹林1.81（1.06-3.09），氯吡格雷1.08（0.64-1.82），VKA 1.08（0.47-2.48），VKA +阿司匹林1.97（0.95-4.07），VKA + 氯吡格雷0.26（0.03-1.91），三联抗血小板治疗1.73(0.50-5.95)、未治疗1.93（1.11-3.36）。

研究结果表明，大多数心肌梗死患者在出血后减少或停止抗血栓治疗。接受阿司匹林单一疗法或出血后未进行任何治疗的患者发生MACE的风险更高。

原始出处：

Hafsah Nabi, Rasmus Rørth,Antithrombotic treatment and major adverse cardiac events after bleeding in patients with myocardial infarction: a retrospective analysis of nationwide registry data

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    2020-07-09 ms1343860338762272

    #主要不良心脏事件#

    0

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    2021-01-11 HNYYM

    #心脏事件#

    0

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    2020-02-06 zhaojie88

    #ART#

    0

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    2020-02-06 wsusan1966

    #抗血栓治疗#

    0

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    2020-02-06 仁者大医

    #回顾性分析#

    0

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    2020-02-06 slcumt

    #HEART#

    0

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    2020-02-06 gwc388

    #抗血栓#

    0

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