Ann Rheum Dis:风湿病患者感染COVID-19的临床特征和结局

2020-06-25 xiangting MedSci原创

感染COVID-19的风湿病患者更有可能需要机械通气,但与非风湿病患者具有相似的临床特征和住院率。

这项研究旨在探讨风湿病患者与非风湿病患者感染2019冠状病毒病(COVID-19)临床表现和结局的差异。

2020年3月1日至4月8日在马萨诸塞州大波士顿地区的合作医疗保健系统中,对感染COVID-19的风湿病患者进行了一项比较队列研究(通过严重急性呼吸系统综合征冠状病毒2 PCR确诊),根据年龄、性别和COVID-19诊断日期按照1:2比例与匹配对照进行比较。分析了COVID-19感染人口学、临床特征和结局的差异。主要结局是住院、重症监护、机械通气和死亡率。

共确定了52例感染COVID-19的风湿病患者(平均年龄63岁;女性占69%),并将其与104例非风湿病对照进行了匹配。大多数风湿病患者(39例,75%)使用免疫抑制剂治疗。风湿病与非风湿病患者的症状和实验室检查结果相似。风湿病与非风湿病患者的住院比例相似(23(44%)vs 42(40%)),p=0.50),但风湿病患者需要重症监护和机械通气的比例较高(11(48%)vs 7(18%),多因素OR 3.11(95%CI 1.07-9.05))。两组的死亡率相似(3(6%)vs 4(4%),p=0.69)。

感染COVID-19的风湿病患者更有可能需要机械通气,但与非风湿病患者具有相似的临床特征和住院率。这些发现对风湿病患者具有重要意义,但需要进一步验证。

原始出处:

Kristin M D’Silva1. Clinical characteristics and outcomes of patients with coronavirus disease 2019 (COVID-19) and rheumatic disease: a comparative cohort study from a US ‘hot spot’. Ann Rheum Dis. 22 June 2020.

 

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