Transl Psychiat:心理治疗还能抗衰老!科学家发现认知行为疗法可在改善社恐的同时,提升抗氧化酶活性,延缓细胞衰老

2020-01-19 奇点糕 奇点网

卡罗琳斯卡研究所的科学家团队近期发现,行为认知疗法不仅能够改善社恐患者的焦虑症状,还能够提升患者体内的端粒酶和抗氧化酶活性,达到抗细胞衰老的作用!这项研究发表在《自然》杂志的子刊《转化精神病学》上。

卡罗琳斯卡研究所的科学家团队近期发现,行为认知疗法不仅能够改善社恐患者的焦虑症状,还能够提升患者体内的端粒酶和抗氧化酶活性,达到抗细胞衰老的作用!这项研究发表在《自然》杂志的子刊《转化精神病学》上。

一般也就梦到甲方无穷无尽地对稿子不满意且说不出来怎么改

先来一点冷水,感觉赚实在是太早了,其实受精神疾病影响的人,本身患上高血压、2型糖尿病等疾病的风险就比较高,近期的一些研究成果认为,这可能是精神疾病患者细胞衰老加速和细胞保护不足造成的。

比如说吧,之前有一项包括1200多人的大型研究发现,与健康人相比,焦虑症患者的白细胞端粒长度要更短。另外的几项研究在抑郁症、情感障碍、创伤后应激障碍等精神问题中也发现了类似的关联。

所以啊,可能是精神疾病的病理作用会促进细胞的衰老。。。

那么治疗了精神疾病,是不是也能顺带把这个促进细胞衰老的“副作用”也治了?别说,还真有点这个意思。

在细胞衰老研究中,除了常见的端粒之外,研究者还比较关注氧化应激,它也会加速细胞衰老和凋亡,像谷胱甘肽过氧化物酶(GPx)这类的抗氧化酶则可以抵消这个过程。

已经有一些研究发现,锂等抗精神病药物或许能够激活端粒酶。不知道心理治疗是不是也有这样的效果呢。

这里要先介绍一下现在应用非常广泛的认知行为治疗(CBT)。这种疗法呢,一方面改变患者的认知和态度,一方面找出能够解决问题的可行办法,在治疗焦虑症、抑郁症等一部分精神疾病上表现出了非常好的效果。

我举个例子吧。假如说你因为害怕飞机失事而不敢坐飞机,那么认知行为疗法就会一方面帮你了解飞机其实很安全、事故率很低,一方面帮你模拟坐飞机的情景、帮你克服恐惧。

在本次要介绍的研究里,社恐患者们采取的就是认知行为疗法。社恐的学术说法叫做社交焦虑障碍(social anxiety disorder,SAD),也是焦虑症的一种。

研究里一共包括了46名社恐患者,他们没有神经疾病、也没有做其他的心理治疗,如果研究期间还有服用抗精神病药物,那么要保证药物剂量不能改变。在试验的前后,通过LSAS-SR量表测定他们的焦虑水平,通过血液样本检查白细胞端粒和血液中的谷胱甘肽过氧化物酶。

噢对了,他们在研究中采用的认知行为疗法,是一套已经经过临床研究验证的模块化疗法,所有人的方案都是一样的,而且是在线上自我练习的(重点),真的是对社恐很友好。

试验结果如何呢?首先,认知行为疗法的抗焦虑效果是非常棒滴,9周治疗结束之后,参与者们的焦虑水平有了非常大幅度的下降。


焦虑水平下降

再看我们关注的两个抗细胞衰老的指标。端粒酶的活性变化不大,不过谷胱甘肽过氧化物酶的水平变化还是比较大的,在治疗之后活性显着增强了。


谷胱甘肽过氧化物酶活性增加

比较有趣的是,当研究者单独分析每个参与者这两个指标水平和治疗效果的时候,发现这二者变化越大,抗焦虑效果就越好。研究还排除了吸烟、BMI、用药史、吸烟史等因素的影响,二者的相关性也是不变的。


二者水平变化与抗焦虑治疗效果成正比

通讯作者Kristoffer M?nsson也在采访中说,“按照我们的解释,这意味着对焦虑症进行有效的心理治疗可以保护细胞免受氧化应激和细胞衰老。”

不过在研究期间,参与者的细胞端粒长度并没有改善,研究者认为这可能是由于时间不够。

当然了,社恐去看心理医生第一目的肯定不是抗衰老,先从不社恐开始才是最重要的!

原始出处:Kristoffer N. T. Månsson, Daniel Lindqvist, Liu L. Yang, et al. Improvement in indices of cellular protection after psychological treatment for social anxiety disorder.Transl Psychiat. 19 December 2019

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content=真的,我一名疑病患者就是经过一段时间心理治疗完全脸色红润了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=71b72024010, createdName=lucy74, createdTime=Mon Feb 03 20:56:02 CST 2020, time=2020-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337114, encodeId=e0f1133e114f4, content=<a href='/topic/show?id=715ae8023ea' target=_blank style='color:#2F92EE;'>#细胞衰老#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78023, encryptionId=715ae8023ea, topicName=细胞衰老)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIW7uIr5ebYvJohUq0dkkVV05uF9jPpeyCrlcx904mUdMI9UKqpO3bt4GkgYBNdv485qT2NsVE27w/132, createdBy=023c2500122, createdName=ms8543593053280928, createdTime=Tue Jan 21 14:12:00 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attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a94010903178, createdName=ms1774076774505970, createdTime=Tue Jan 21 14:12:00 CST 2020, time=2020-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=378335, encodeId=a78e3e833515, content=学习了很有用不錯, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Jan 20 07:21:55 CST 2020, time=2020-01-20, status=1, ipAttribution=)]
    2020-02-10 bsmagic9140
  4. 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  5. 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  6. 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    2020-02-03 lucy74

    真的,我一名疑病患者就是经过一段时间心理治疗完全脸色红润了

    0

  7. 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    2020-01-20 飛歌

    学习了很有用不錯

    0

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