JCEM:餐后血糖下降与正常血糖个体的代谢紊乱和心血管疾病风险相关

2021-11-23 MedSci原创 MedSci原创

餐后血糖下降与代谢紊乱、代谢综合征及其相关成分疾病以及心血管疾病风险相关。血糖下降可能是潜在的代谢异常标志。

代谢紊乱和血管疾病威胁着人类健康。许多研究评估了糖尿病患者的代谢紊乱与心血管疾病的现象。然而,在血糖正常的个体中,葡萄糖调节、代谢和心血管疾病之间的关系尚未明确。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在探讨餐后血糖下降、代谢紊乱和心血管疾病风险之间的关联。

研究人员分析了来自甲状腺疾病、碘状态和糖尿病流行病学调查(TIDE)研究的受试者数据,其中包括了来自中国大陆所有31个省的38878名正常血糖的个体。

该研究的主要结局指标为根据餐后血糖下降计算的代谢紊乱及其相关成分的患病率和心血管疾病风险。研究人员使用餐后血糖下降四分位数的Logistic回归模型进一步探讨这些疾病的患病情况是否与餐后血糖下降相关。

血糖下降的第四个与第一个四分位数相比的比值比对于代谢紊乱为0.59(95%置信区间(CI)为0.55-0.63,P<0.001),对于代谢综合征为0.48(95%CI为0.44-0.53,P<0.001),对于高尿酸血症为0.54(95%CI为0.50-0.59,P<0.001)。血糖下降的第四个与第一个四分位数相比10年心血管疾病风险>20%的比值比为0.67(95%CI为0.52-0.85,P<0.001)。针对BMI进行调整后的模型得到了类似的结果。

由此可见,餐后血糖下降与代谢紊乱、代谢综合征及其相关成分疾病以及心血管疾病风险相关。血糖下降可能是潜在的代谢异常标志。

原始出处:

Ying Sun,et al.Postprandial glycemic dips are associated with metabolic disorders and CVD risk in euglycemic individuals.JCEM.2021.https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgab831/6428637?redirectedFrom=fulltext

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    2022-02-09 仁者大医
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    2022-08-08 achengzhao
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    2021-12-04 Lqqqqqqccc

    值得

    0

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  5. 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authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210501/d91d6ce70b4e455aa533199fca50e35e/1c9beeb23e9741f68c36bc03b6395f06.jpg, createdBy=4b3c5490975, createdName=刘欣怡666, createdTime=Tue Nov 23 16:00:58 CST 2021, time=2021-11-23, status=1, ipAttribution=)]
  6. 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replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu Nov 25 06:11:52 CST 2021, time=2021-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1073399, encodeId=323a10e339990, content=不错!谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85e91537175, createdName=RENYUQIONG200798, createdTime=Wed Nov 24 07:59:49 CST 2021, time=2021-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1073268, encodeId=f62410e3268e3, content=好文章,值得阅读。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu Nov 25 06:11:52 CST 2021, time=2021-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1073399, encodeId=323a10e339990, content=不错!谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85e91537175, createdName=RENYUQIONG200798, createdTime=Wed Nov 24 07:59:49 CST 2021, time=2021-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1073268, encodeId=f62410e3268e3, content=好文章,值得阅读。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210501/d91d6ce70b4e455aa533199fca50e35e/1c9beeb23e9741f68c36bc03b6395f06.jpg, createdBy=4b3c5490975, createdName=刘欣怡666, createdTime=Tue Nov 23 16:00:58 CST 2021, time=2021-11-23, status=1, ipAttribution=)]
    2021-11-24 RENYUQIONG200798

    不错!谢谢!

    0

  8. 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authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210501/d91d6ce70b4e455aa533199fca50e35e/1c9beeb23e9741f68c36bc03b6395f06.jpg, createdBy=4b3c5490975, createdName=刘欣怡666, createdTime=Tue Nov 23 16:00:58 CST 2021, time=2021-11-23, status=1, ipAttribution=)]
    2021-11-23 yangchou

    好文章,值得阅读。

    0

  9. 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    2021-11-23 ms4000000575043187

    JCEM

    0

  10. 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    2021-11-23 刘欣怡666

    给个积分

    0

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