Heart:瓣膜性风湿心脏病孕妇不良心脏事件的预测

2020-07-22 MedSci原创 MedSci原创

心力衰竭仍然是妊娠或产褥期最常见的不良心脏事件。将病变特定的特征和临床信息结合到一个简单有效的预测评分中,可用于常规临床实践。

近日,心脏病领域权威杂志Heart上发表了一篇研究文章,这项研究旨在评估风湿性心脏瓣膜病(RHD)孕妇不良心脏事件的发生率,并对其进行临床风险评分。

这是一项观察性研究,受试者为印度南部一家三级医院就诊的RHD孕妇。研究人员收集了受试者出院前的产科史、病史、母亲并发症和围产期结局的数据。分析中包括了681名妇女中的800次妊娠。该研究的主要结局为复合不良心脏事件,定义为发生一种或多种并发症,例如死亡、心脏骤停、心力衰竭、血栓栓塞和新发心律失常引起的脑血管意外。

在681名RHD妇女中,有180名(26.3%)被诊断为妊娠。122例(14.9%)孕妇发生妊娠/产后复合不良心脏结局,其中12例死于该疾病。在多变量分析中,先前的不良心脏事件(OR=8.35,95%CI为3.54至19.71)、心脏药物(OR=0.53,95%CI为0.32至0.86)、二尖瓣狭窄(轻度OR=2.48,95%CI为1.08至5.69;中度OR=2.23,95%CI为1.19至4.18;严重OR=7.72,95%CI为4.05至12.89)、瓣膜置换术(OR=2.53,95%CI为1.28至5.02)和肺动脉高压(OR=6.90,95%CI为3.81至12.46)可以预测复合不良心脏事件,并具有良好的辨别力(曲线下面积=0.803),并具有可以接受的校准性能。建议将这些因素结合在一起的预测评分可用于临床。

由此可见,心力衰竭仍然是妊娠或产褥期最常见的不良心脏事件。将病变特定的特征和临床信息结合到一个简单有效的预测评分中,可用于常规临床实践。

原始出处:

Jyoti Baghel.et al.Prediction of adverse cardiac events in pregnant women with valvular rheumatic heart disease.heart.2020.https://heart.bmj.com/content/early/2020/07/21/heartjnl-2020-316648

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    2022-01-25 ms2000001047183780

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    2020-07-24 zhaojie88
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    2020-07-24 slcumt
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    2020-07-22 14757fdfm46暂无昵称

    学习

    0

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    2020-07-22 1240394fm61暂无昵称

    不错

    0

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大多数因SARS-CoV-2感染而入院的孕妇都是在孕中期或中晚期,大多数患者预后良好,SARS-CoV-2在婴儿中的传播并不常见,但黑人或少数民族妇女感染率高需引起注意

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据深圳市第三人民医院网站消息,5月30日,深圳首名新冠病毒无症状感染孕妇小雨(化名)在该院顺利生下一名健康男婴。经检测,该男婴没有感染新冠病毒,但一出生就携带了新冠病毒抗体。

IBD:患有炎症性肠病的孕妇早期停用英夫利昔单抗的影响

患有炎症性肠病(IBD)的孕妇尽早停用英夫利昔单抗(IFX)可以降低胎儿在宫内暴露于该药物的风险,但可能增加疾病发作的风险,从而导致不良的妊娠结局。