JCEM:BMI对分化型甲状腺癌侵袭性表现和临床结局的潜在影响

2019-12-31 xing.T MedSci原创

由此可见,无论是在诊断时还是在随访期间,研究人员都无法证明BMI与DTC的侵袭性之间存在任何关联。这些数据表明,DTC手术后评估和治疗态度以及对DTC的随访应基于适用于普通人群的风险类别,而无需关注BMI。

肥胖是包括分化型甲状腺癌(DTC)在内的几种癌症的危险因素。此外,也有研究将它也作为DTC侵略性的潜在危险因素,但到目前为止收集的数据相互矛盾。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员的目的是评估体重指数(BMI)、DTC诊断时的侵袭性和临床结局之间的关系。

研究人员评估了1058例连续就诊的接受全甲状腺切除术治疗的DTC患者,并在首次接受I131治疗时入组。根据体重指数将患者分为四组:体重不足(<18.5 kg/m2),体重正常(18.5-24.9 kg/m2),超重(25-29.9 kg/m2)和肥胖(≥30 kg/m2)。研究人员根据2015 ATA指南评估了诊断时DTC的组织学侵袭性和临床结局。

两组之间在组织学特征、ATA复发风险、放射性碘给药活性和首次I131治疗后转移性疾病的患病率方面均无差异。此外,在随访结束时(中位时间为5.7年),进一步治疗的次数和临床反应均无明显差异。

由此可见,无论是在诊断时还是在随访期间,研究人员都无法证明BMI与DTC的侵袭性之间存在任何关联。这些数据表明,DTC手术后评估和治疗态度以及对DTC的随访应基于适用于普通人群的风险类别,而无需关注BMI。

原始出处:

Antonio Matrone,et al.Potential impact of BMI on the aggressiveness of presentation and clinical outcome of Differentiated Thyroid Cancer.J Clin Endocrinol Metab.2019.https://doi.org/10.1210/clinem/dgz312

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    2020-03-18 achengzhao
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    2020-03-21 smallant2015
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    2020-01-02 sunyl07

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