Stroke:卒中后肺炎的临床意义

2021-09-14 MedSci原创 MedSci原创

卒中后前3个月内,三分之二的肺炎发生在卒中后第一周,发病高峰为卒中后第三天。评估肺炎预防策略的最佳时期是卒中后的前4天。然而,后来发生的肺炎也与患者不良结局或死亡有关。

卒中后发生肺炎与患者预后不良或死亡风险增加相关。

近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员在几个时间点评估了卒中后肺炎的时间特征及其与患者不良结局之间的关联,以确定检查肺炎预防策略的最佳时期。

研究人员分析了存储在VISTA(虚拟国际卒中试验档案)中的个体患者数据,这些数据来自随机急性卒中试验,并评估了卒中后前90天内肺炎的发生情况。在不同的随访时间点,研究人员分别通过Logistic和Cox比例风险回归计算了肺炎与不良结局和死亡之间相关性的调整后比值比和风险比。


在10821名患者中,1017名(9.4%)患者共发生1076次肺炎。卒中后第一周发生了689次(64.0%)肺炎。发病高峰多为卒中后第三天,中位发病时间为卒中后4.0天(四分位距为2-12)。肺炎与不良结局(调整后的比值比为4.8[95%CI为3.8-6.1])或死亡(调整后的风险比为4.1[95%CI为3.7-4.6])的风险增加相关。这些关联在整个90天的随访期间持续存在。
 
由此可见,卒中后前3个月内,三分之二的肺炎发生在卒中后第一周,发病高峰为卒中后第三天。评估肺炎预防策略的最佳时期是卒中后的前4天。然而,后来发生的肺炎也与患者不良结局或死亡有关。

原始出处:

Jeroen C. de Jonge.et al.Temporal Profile of Pneumonia After Stroke.stroke.2021.https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.032787

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1671445, encodeId=b8b816e1445ae, content=<a href='/topic/show?id=9f4e360191a' target=_blank style='color:#2F92EE;'>#卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36019, encryptionId=9f4e360191a, topicName=卒中后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff7426824786, createdName=waiwai3039, createdTime=Mon Jul 18 09:21:03 CST 2022, time=2022-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057404, encodeId=d2ac105e404aa, content=<a href='/topic/show?id=b64035999ca' target=_blank style='color:#2F92EE;'>#卒中#</a>卒中后前3个月内,三分之二的肺炎发生在卒中后第一周,发病高峰为卒中后第三天。评估肺炎预防策略的最佳时期是卒中后的前4天。然而,后来发生的肺炎也与患者不良结局或死亡有关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35999, encryptionId=b64035999ca, topicName=卒中)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTInOuicIVN8Y32NO4Q53Zpd86ObmNp2WIotichCD0qQHaUBeHj7hgwQBCzX7ce4aEw5ZP8icQQfLH9Zw/132, createdBy=4ec21734756, createdName=1def6e10m76(暂无匿称), createdTime=Mon Oct 04 09:07:21 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051532, encodeId=a3b91051532d0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df324723890, createdName=452946589, createdTime=Wed Sep 15 16:58:29 CST 2021, time=2021-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052603, encodeId=dd111052603dc, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue Sep 14 22:21:03 CST 2021, time=2021-09-14, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1671445, encodeId=b8b816e1445ae, content=<a href='/topic/show?id=9f4e360191a' target=_blank style='color:#2F92EE;'>#卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36019, encryptionId=9f4e360191a, topicName=卒中后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff7426824786, createdName=waiwai3039, createdTime=Mon Jul 18 09:21:03 CST 2022, time=2022-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057404, encodeId=d2ac105e404aa, content=<a href='/topic/show?id=b64035999ca' target=_blank style='color:#2F92EE;'>#卒中#</a>卒中后前3个月内,三分之二的肺炎发生在卒中后第一周,发病高峰为卒中后第三天。评估肺炎预防策略的最佳时期是卒中后的前4天。然而,后来发生的肺炎也与患者不良结局或死亡有关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35999, encryptionId=b64035999ca, topicName=卒中)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTInOuicIVN8Y32NO4Q53Zpd86ObmNp2WIotichCD0qQHaUBeHj7hgwQBCzX7ce4aEw5ZP8icQQfLH9Zw/132, createdBy=4ec21734756, createdName=1def6e10m76(暂无匿称), createdTime=Mon Oct 04 09:07:21 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051532, encodeId=a3b91051532d0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df324723890, createdName=452946589, createdTime=Wed Sep 15 16:58:29 CST 2021, time=2021-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052603, encodeId=dd111052603dc, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue Sep 14 22:21:03 CST 2021, time=2021-09-14, status=1, ipAttribution=)]
    2021-10-04 1def6e10m76(暂无匿称)

    #卒中#卒中后前3个月内,三分之二的肺炎发生在卒中后第一周,发病高峰为卒中后第三天。评估肺炎预防策略的最佳时期是卒中后的前4天。然而,后来发生的肺炎也与患者不良结局或死亡有关。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1671445, encodeId=b8b816e1445ae, content=<a href='/topic/show?id=9f4e360191a' target=_blank style='color:#2F92EE;'>#卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36019, encryptionId=9f4e360191a, topicName=卒中后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff7426824786, createdName=waiwai3039, createdTime=Mon Jul 18 09:21:03 CST 2022, time=2022-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057404, encodeId=d2ac105e404aa, content=<a href='/topic/show?id=b64035999ca' target=_blank style='color:#2F92EE;'>#卒中#</a>卒中后前3个月内,三分之二的肺炎发生在卒中后第一周,发病高峰为卒中后第三天。评估肺炎预防策略的最佳时期是卒中后的前4天。然而,后来发生的肺炎也与患者不良结局或死亡有关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35999, encryptionId=b64035999ca, topicName=卒中)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTInOuicIVN8Y32NO4Q53Zpd86ObmNp2WIotichCD0qQHaUBeHj7hgwQBCzX7ce4aEw5ZP8icQQfLH9Zw/132, createdBy=4ec21734756, createdName=1def6e10m76(暂无匿称), createdTime=Mon Oct 04 09:07:21 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051532, encodeId=a3b91051532d0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df324723890, createdName=452946589, createdTime=Wed Sep 15 16:58:29 CST 2021, time=2021-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052603, encodeId=dd111052603dc, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue Sep 14 22:21:03 CST 2021, time=2021-09-14, status=1, ipAttribution=)]
    2021-09-15 452946589

    学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1671445, encodeId=b8b816e1445ae, content=<a href='/topic/show?id=9f4e360191a' target=_blank style='color:#2F92EE;'>#卒中后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36019, encryptionId=9f4e360191a, topicName=卒中后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ff7426824786, createdName=waiwai3039, createdTime=Mon Jul 18 09:21:03 CST 2022, time=2022-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1057404, encodeId=d2ac105e404aa, content=<a href='/topic/show?id=b64035999ca' target=_blank style='color:#2F92EE;'>#卒中#</a>卒中后前3个月内,三分之二的肺炎发生在卒中后第一周,发病高峰为卒中后第三天。评估肺炎预防策略的最佳时期是卒中后的前4天。然而,后来发生的肺炎也与患者不良结局或死亡有关。, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35999, encryptionId=b64035999ca, topicName=卒中)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTInOuicIVN8Y32NO4Q53Zpd86ObmNp2WIotichCD0qQHaUBeHj7hgwQBCzX7ce4aEw5ZP8icQQfLH9Zw/132, createdBy=4ec21734756, createdName=1def6e10m76(暂无匿称), createdTime=Mon Oct 04 09:07:21 CST 2021, time=2021-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1051532, encodeId=a3b91051532d0, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df324723890, createdName=452946589, createdTime=Wed Sep 15 16:58:29 CST 2021, time=2021-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052603, encodeId=dd111052603dc, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Tue Sep 14 22:21:03 CST 2021, time=2021-09-14, status=1, ipAttribution=)]
    2021-09-14 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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