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Brit J Cancer：癌症家族史与儿童和青年人睾丸癌风险

2019-04-11 xing.T 网络

癌症家族史儿童青年人睾丸癌风险
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该研究发现患有TC、癌、间皮瘤、肉瘤、恶性黑素瘤和恶性神经上皮肿瘤家族史的儿童和年轻人患TC的风险增加。遗传性癌症综合征可能是本研究报道的一些关联的基础。

近日，肿瘤领域权威杂志British Journal of Cancer上发表了一篇研究文章，该研究的目的是评估癌症家族史与年轻成人睾丸癌（TC）风险之间的关系。

这是一项前瞻性队列研究，纳入了1951-2015年出生的1974287名男性，其中2686名参与者在30岁之前被诊断为TC。 

男性亲属的TC病史与儿童和青年人的TC诊断显著相关，包括兄弟（6.3倍）、儿子（4.7倍）、父亲（4.4倍）、叔叔（2.0倍）和舅舅（1.9倍）。父亲被诊断患有癌或肉瘤的个体表现出高风险（分别为1.1倍和1.8倍）。间皮瘤家族史与TC的风险呈正相关[（父亲（2.8倍）、母亲（4.6倍）和舅舅和阿姨（4.4倍）]。当兄弟姐妹被诊断为恶性黑色素瘤时，也观察到风险增加（1.4倍）。当父亲（11.1倍）、叔叔（4.9倍）以及舅舅和姨妈（4.6倍）被诊断患有恶性神经上皮肿瘤时，TC的风险也增加。

该研究发现患有TC、癌、间皮瘤、肉瘤、恶性黑素瘤和恶性神经上皮肿瘤家族史的儿童和年轻人患TC的风险增加。遗传性癌症综合征可能是本研究报道的一些关联的基础。 

原始出处：

Ruby Del Risco Kollerud,et al.Family history of cancer and risk of paediatric and young adult’s testicular cancer: A Norwegian cohort study.British Journal of Cancer. 2019.https://www.nature.com/articles/s41416-019-0445-2

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    2020-01-31 sjq027

    #癌风险#

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    2019-06-23 zll0625

    #青年人#

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    2019-08-26 ms55066533437992

    #癌症家族史#

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    2019-04-13 zhangph

    #睾丸#

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    2019-04-13 396094184_42047357

    #家族史#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2061844, encodeId=4aba2061844d7, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Fri Jan 31 01:29:00 CST 2020, time=2020-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1916808, encodeId=026c191680896, content=<a href='/topic/show?id=f24198994a6' target=_blank style='color:#2F92EE;'>#青年人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98994, encryptionId=f24198994a6, topicName=青年人)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=284b425, createdName=zll0625, createdTime=Sun Jun 23 02:29:00 CST 2019, time=2019-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1800040, encodeId=a56618000408e, content=<a href='/topic/show?id=66cde13478d' target=_blank style='color:#2F92EE;'>#癌症家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71347, encryptionId=66cde13478d, topicName=癌症家族史)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/lGEyfsKnIkkH93xUPMrUUycLh2XOfJJsphwPsVqDx8somSOepIFy9QE0MVAwDW3AS7V1epJ4tbPL9ADJLicvm8A/132, createdBy=b5132500067, createdName=ms55066533437992, createdTime=Mon Aug 26 06:29:00 CST 2019, time=2019-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368375, encodeId=929713683e508, content=<a href='/topic/show?id=2fa7e3068b9' target=_blank style='color:#2F92EE;'>#睾丸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73068, encryptionId=2fa7e3068b9, topicName=睾丸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6976269, createdName=zhangph, createdTime=Sat Apr 13 06:29:00 CST 2019, time=2019-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479802, encodeId=712f14e98029a, content=<a href='/topic/show?id=fe7e4641ed7' target=_blank style='color:#2F92EE;'>#家族史#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46417, encryptionId=fe7e4641ed7, topicName=家族史)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f367584357, createdName=396094184_42047357, createdTime=Sat Apr 13 06:29:00 CST 2019, time=2019-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364484, encodeId=c37f3644849a, content=学习了，涨知识了！, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Thu Apr 11 15:50:48 CST 2019, time=2019-04-11, status=1, ipAttribution=)]
    2019-04-11 王秀

    学习了，涨知识了！

    0