JACC:成年早期累计血压的暴露与中年心脏功能障碍有关

2015-06-23 MedSci MedSci原创

    背景  累积血压(BP)的暴露可能会影响心脏功能,在以后的生活中诱发人的心脏衰竭。    意义  本研究旨在探讨累积暴露较高的BP如何在年轻,中年是期影响左心室(LV)功能。    方法  该CARDIA(在年轻成人冠状动脉风险发展)研究在1985年和1986年(基准线)前瞻性纳入5115名健康美国黑

背景  
累积血压(BP)的暴露可能会影响心脏功能,在以后的生活中诱发人的心脏衰竭。

意义  
本研究旨在探讨累积暴露较高的BP如何在年轻,中年是期影响左心室(LV)功能。

方法  
该CARDIA(在年轻成人冠状动脉风险发展)研究在1985年和1986年(基准线)前瞻性纳入5115名健康美国黑人和白人。在25年检查时,左室功能由2维超声心动图测定;心脏变形的细节通过超声斑点追踪显像进行评估。研究人员通过基准线BP累积暴露和25年时的检查(毫米汞柱×年)来表示长期暴露的血压水平。线性回归和Logistic回归模型被用来量化BP在成年早期(18至30岁)到中年(43〜55岁)重复测量的相关性。

结果  
在2479名参与者中,累计BP措施不与左室射血分数相关;然而,高累积暴露收缩压(SBP)和舒张压(DBP)均与纵向应变率较低相关(P<0.001)。对于舒张功能,更高的累积暴露于收缩压和舒张压均与低舒张早期纵向峰值应变率相关。值得注意的是,与SBP相比,较高的DBP(每个SD的增加)与舒张功能障碍有较强的关联。

结论  从成年早期到中年较高的累积暴露BP超过25年,与中年初期的LV收缩和舒张功能障碍的有关。

原始出处:
Satoru Kishi, MD∗; Gisela Teixido-Tura, MD, PhD†; Hongyan Ning, MD‡; Bharath Ambale Venkatesh, PhD∗; Colin Wu, PhD§; Andre Almeida, MD∗; Eui-Young Choi, MD∗; Ola Gjesdal, MD∗; David R. Jacobs, Jr., PhD‖; Pamela J. Schreiner, PhD‖; Samuel S. Gidding, MD¶; Kiang Liu, PhD‡; João A.C. Lima, MD∗,Cumulative Blood Pressure in Early Adulthood and Cardiac Dysfunction in Middle Age,JACC,2015.6.23

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    2015-09-06 hbwxf
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    2015-06-25 huaxipanxing

    看看

    0

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    2015-06-25 nizongzan

    恩,好好学习

    0

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    2015-06-24 fatalmelanie

    血压要严格控制的好

    0

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    2015-06-23 medcardio

    这个研究很令人震撼,随访时间非常的漫长。

    0

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