Prostate Cancer P D:前列腺癌检测的种族差异

2020-07-14 AlexYang MedSci原创

Stockholm3测试改善了≥2格林森等级分组(GG≥2)前列腺癌的检测,然而,在具有临床实践模式和种族差异的美国群体中还尚未有评估。最近,有研究人员鉴定了不同种族亚群中PC风险情况,并

Stockholm3测试改善了≥2格林森等级分组(GG≥2)前列腺癌的检测,然而,在具有临床实践模式和种族差异的美国群体中还尚未有评估。最近,有研究人员鉴定了不同种族亚群中PC风险情况,并比较了PC在不同种族亚群中的差异,并阐释了Stockholm3测试在这些亚群中的表现。

研究包括了504名芝加哥男性和6980名斯德哥尔摩男性。研究发现,在非裔美国(AA)男性中,51%的男性检测为GG≥2,而在风险匹配的斯德哥尔摩男性男性中只有34%的检测为GG≥2(OR: 2.1, p<0.001)。而斯德哥尔摩男性与非西班牙裔白人男性相比较时GG≥2检测比例没有统计学差异(31% vs. 27%, OR: 1.2, p=0.42)。另外,Stockholm3测试在AA、非西班牙裔白人男性和西班牙裔白人男性中的AUC分别为0.85、0.89和0.90。

最后,研究人员指出,GG≥2 PC的风险在AA男性中风险高。因此,研究人员假设Stockholm3测试在多种族队列中的预测值较好,且在AA男性中重新校准的可能性较大。

原始出处:

Hari T. Vigneswaran, Andrea Discacciati, Peter H. Gann et al. Ethnic variation in prostate cancer detection: a feasibility study for use of the Stockholm3 test in a multiethnic U.S. cohort. Prostate Cancer P D. 08 Jul 2020

 

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    2020-07-16 lsndxfj
  4. [GetPortalCommentsPageByObjectIdResponse(id=1791622, encodeId=a32f1e91622c3, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Wed Sep 02 03:24:01 CST 2020, time=2020-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353590, encodeId=b468135359029, content=<a href='/topic/show?id=29e1e4781f1' target=_blank style='color:#2F92EE;'>#种族差异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74781, encryptionId=29e1e4781f1, topicName=种族差异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jul 16 04:24:01 CST 2020, time=2020-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364623, encodeId=df001364623af, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Thu Jul 16 04:24:01 CST 2020, time=2020-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602284, encodeId=ced416022840a, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Thu Jul 16 04:24:01 CST 2020, time=2020-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040785, encodeId=b1291040e8578, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Jul 14 16:24:01 CST 2020, time=2020-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802770, encodeId=1a19802e7069, content=很好的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43a21971117, createdName=njwbhuang, createdTime=Tue Jul 14 15:38:36 CST 2020, time=2020-07-14, status=1, ipAttribution=)]
    2020-07-16 sunylz
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    2020-07-14 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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    2020-07-14 njwbhuang

    很好的文章

    0

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本研究旨在确定一级亲属(FDR)中的前列腺癌家族史与前列腺癌的发病率和死亡率之间的关系。

Brit J Cancer:抗PD-L1免疫治疗和放疗联用对肿瘤免疫微环境的影响

放疗能够增强先天性和适应性抗肿瘤免疫。然而,并不清楚该效应能否通过免疫治疗和放疗联用治疗前列腺癌来增强。最近,有研究人员调查了预临床前列腺癌模型对放疗的肿瘤免疫微环境响应情况,并检测了是否放疗诱导的肿

J Urol:GnRH激动剂 VS拮抗剂在晚期前列腺癌和心血管疾病患者中的心血管发病率

雄激素剥夺疗法可能会增加患心血管疾病的风险。有限的数据表明,与GnRH激动剂相比,GnRH(促性腺激素释放激素)拮抗剂可能会降低心血管疾病的风险。

Prostate:前列腺癌男性患者前列腺中阿托伐他汀的进入途径和浓度

他汀类药物对前列腺癌在体外和体内都有抗癌作用。目前尚不清楚这是由于全身性降胆固醇还是直接抑制前列腺局部生长。他汀类药物能否进入前列腺也不清楚,理论上,亲脂性的他汀类药物可以通过被动扩散的方式通过富含脂

Cancer:PLCO中前列腺癌总转移和进展率

前列腺、肺、结肠直肠和卵巢(PLCO)癌症筛查试验评估了前列腺特异性抗原筛查和数字直肠检查对前列腺癌死亡率的影响。另一个研究终点是总转移性疾病的负担。

Eur Urol:转移去势抵抗性前列腺癌男性双相雄激素治疗的多队列开放标签II期试验

循环高剂量睾酮注射治疗,也被称为双相雄激素治疗(BAT),是转移去势抵抗性前列腺癌(mCRPC)男性患者的一种新的治疗策略。BAT在起始的研究中表现出了临床活性,也许能够恢复对雄激素受体(AR)靶向治