Sci Signal:基因表达的先后次序决定沙门氏菌表面脂多糖的修饰特征

2018-05-14 重磅学术期刊 学术经纬

对革兰氏阴性菌表面的脂多糖(lipopolysaccharide, LPS)的修饰可以被用来逃避宿主的免疫反应或产生对抗生素的抗性。

对革兰氏阴性菌表面的脂多糖(lipopolysaccharide, LPS)的修饰可以被用来逃避宿主的免疫反应或产生对抗生素的抗性。例如,降低LPS中脂质A(lipid A)负电荷的修饰能够提高沙门氏菌(Salmonella)对多粘菌素B(polymyxin B)和其它阳离子抗菌素的抗性。耶鲁大学医学院(Yale School of Medicine)的研究人员发现不同刺激虽然在沙门氏菌中激发同样一组脂质A修饰酶的生成,但是它们可以造成不同的脂质A修饰特征。原因是不同刺激激活编码脂质A修饰酶的基因的动力学特征不同,这导致不同种脂质A修饰酶产生的时间顺序出现了变化,从而改变了脂质A的修饰特征和对多粘菌素B的抗性。这项研究揭示了细菌利用有限数量的酶来针对不同刺激生成多种适应反应的机制。

原始出处:

Xinyu Hong.et al.Gene expression kinetics governs stimulus-specific decoration of the Salmonella outer membrane.Sci Signal.08 May 2018:Vol. 11, Issue 529, eaar7921

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (9)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1794003, encodeId=74d41e940037a, content=<a href='/topic/show?id=7b3d1630617' target=_blank style='color:#2F92EE;'>#Signal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16306, encryptionId=7b3d1630617, topicName=Signal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sat May 26 17:37:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036183, encodeId=ab822036183db, content=<a href='/topic/show?id=ae7816304dc' target=_blank style='color:#2F92EE;'>#Sign#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16304, encryptionId=ae7816304dc, topicName=Sign)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9ed371, createdName=楚秀娟, createdTime=Mon May 28 13:37:00 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348066, encodeId=3c42134806615, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399146, encodeId=cea6139914671, content=<a href='/topic/show?id=1e7464490b7' target=_blank style='color:#2F92EE;'>#沙门氏菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64490, encryptionId=1e7464490b7, topicName=沙门氏菌)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/dZj08ckjV0K1emuaDxP7G2DicoLPC5gxtjiatZukfCclP1r3RbxcTgibCpicZkfazrzGUU2iatBBWBNuPTP10a3g5Mw/0, createdBy=12552195639, createdName=lifestar, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429860, encodeId=96b4142986060, content=<a href='/topic/show?id=cc2584301d4' target=_blank style='color:#2F92EE;'>#脂多糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84301, encryptionId=cc2584301d4, topicName=脂多糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f354234967, createdName=小刀医生, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569315, encodeId=adad156931531, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315423, encodeId=543b31542322, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue May 15 22:02:51 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315400, encodeId=d2be31540044, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Tue May 15 19:51:37 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315071, encodeId=b7e83150e1da, content=对革兰氏阴性菌表面的脂多糖(lipopolysaccharide.LPS)的修饰可以被用来逃避宿主的免疫反应或产生对抗生素的抗性.例如.降低LPS中脂质A(lipidA)负电荷的修饰能够提高沙门氏菌(Salmonella)对多粘菌素B(polymyxinB)和其它阳离子抗菌素的抗性., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon May 14 18:44:30 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-26 yaanren
  2. [GetPortalCommentsPageByObjectIdResponse(id=1794003, encodeId=74d41e940037a, content=<a href='/topic/show?id=7b3d1630617' target=_blank style='color:#2F92EE;'>#Signal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16306, encryptionId=7b3d1630617, topicName=Signal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sat May 26 17:37:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036183, encodeId=ab822036183db, content=<a href='/topic/show?id=ae7816304dc' target=_blank style='color:#2F92EE;'>#Sign#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16304, encryptionId=ae7816304dc, topicName=Sign)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9ed371, createdName=楚秀娟, createdTime=Mon May 28 13:37:00 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348066, encodeId=3c42134806615, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399146, encodeId=cea6139914671, content=<a href='/topic/show?id=1e7464490b7' target=_blank style='color:#2F92EE;'>#沙门氏菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64490, encryptionId=1e7464490b7, topicName=沙门氏菌)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/dZj08ckjV0K1emuaDxP7G2DicoLPC5gxtjiatZukfCclP1r3RbxcTgibCpicZkfazrzGUU2iatBBWBNuPTP10a3g5Mw/0, createdBy=12552195639, createdName=lifestar, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429860, encodeId=96b4142986060, content=<a href='/topic/show?id=cc2584301d4' target=_blank style='color:#2F92EE;'>#脂多糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84301, encryptionId=cc2584301d4, topicName=脂多糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f354234967, createdName=小刀医生, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569315, encodeId=adad156931531, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315423, encodeId=543b31542322, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue May 15 22:02:51 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315400, encodeId=d2be31540044, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Tue May 15 19:51:37 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315071, encodeId=b7e83150e1da, content=对革兰氏阴性菌表面的脂多糖(lipopolysaccharide.LPS)的修饰可以被用来逃避宿主的免疫反应或产生对抗生素的抗性.例如.降低LPS中脂质A(lipidA)负电荷的修饰能够提高沙门氏菌(Salmonella)对多粘菌素B(polymyxinB)和其它阳离子抗菌素的抗性., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon May 14 18:44:30 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-28 楚秀娟
  3. [GetPortalCommentsPageByObjectIdResponse(id=1794003, encodeId=74d41e940037a, content=<a href='/topic/show?id=7b3d1630617' target=_blank style='color:#2F92EE;'>#Signal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16306, encryptionId=7b3d1630617, topicName=Signal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sat May 26 17:37:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036183, encodeId=ab822036183db, content=<a href='/topic/show?id=ae7816304dc' target=_blank style='color:#2F92EE;'>#Sign#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16304, encryptionId=ae7816304dc, topicName=Sign)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9ed371, createdName=楚秀娟, createdTime=Mon May 28 13:37:00 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348066, encodeId=3c42134806615, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399146, encodeId=cea6139914671, content=<a href='/topic/show?id=1e7464490b7' target=_blank style='color:#2F92EE;'>#沙门氏菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64490, encryptionId=1e7464490b7, topicName=沙门氏菌)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/dZj08ckjV0K1emuaDxP7G2DicoLPC5gxtjiatZukfCclP1r3RbxcTgibCpicZkfazrzGUU2iatBBWBNuPTP10a3g5Mw/0, createdBy=12552195639, createdName=lifestar, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429860, encodeId=96b4142986060, content=<a href='/topic/show?id=cc2584301d4' target=_blank style='color:#2F92EE;'>#脂多糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84301, encryptionId=cc2584301d4, topicName=脂多糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f354234967, createdName=小刀医生, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569315, encodeId=adad156931531, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315423, encodeId=543b31542322, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue May 15 22:02:51 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315400, encodeId=d2be31540044, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Tue May 15 19:51:37 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315071, encodeId=b7e83150e1da, content=对革兰氏阴性菌表面的脂多糖(lipopolysaccharide.LPS)的修饰可以被用来逃避宿主的免疫反应或产生对抗生素的抗性.例如.降低LPS中脂质A(lipidA)负电荷的修饰能够提高沙门氏菌(Salmonella)对多粘菌素B(polymyxinB)和其它阳离子抗菌素的抗性., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon May 14 18:44:30 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1794003, encodeId=74d41e940037a, content=<a href='/topic/show?id=7b3d1630617' target=_blank style='color:#2F92EE;'>#Signal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16306, encryptionId=7b3d1630617, topicName=Signal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sat May 26 17:37:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036183, encodeId=ab822036183db, content=<a href='/topic/show?id=ae7816304dc' target=_blank style='color:#2F92EE;'>#Sign#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16304, encryptionId=ae7816304dc, topicName=Sign)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9ed371, createdName=楚秀娟, createdTime=Mon May 28 13:37:00 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348066, encodeId=3c42134806615, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399146, encodeId=cea6139914671, content=<a href='/topic/show?id=1e7464490b7' target=_blank style='color:#2F92EE;'>#沙门氏菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64490, encryptionId=1e7464490b7, topicName=沙门氏菌)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/dZj08ckjV0K1emuaDxP7G2DicoLPC5gxtjiatZukfCclP1r3RbxcTgibCpicZkfazrzGUU2iatBBWBNuPTP10a3g5Mw/0, createdBy=12552195639, createdName=lifestar, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429860, encodeId=96b4142986060, content=<a href='/topic/show?id=cc2584301d4' target=_blank style='color:#2F92EE;'>#脂多糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84301, encryptionId=cc2584301d4, topicName=脂多糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f354234967, createdName=小刀医生, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569315, encodeId=adad156931531, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315423, encodeId=543b31542322, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue May 15 22:02:51 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315400, encodeId=d2be31540044, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Tue May 15 19:51:37 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315071, encodeId=b7e83150e1da, content=对革兰氏阴性菌表面的脂多糖(lipopolysaccharide.LPS)的修饰可以被用来逃避宿主的免疫反应或产生对抗生素的抗性.例如.降低LPS中脂质A(lipidA)负电荷的修饰能够提高沙门氏菌(Salmonella)对多粘菌素B(polymyxinB)和其它阳离子抗菌素的抗性., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon May 14 18:44:30 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1794003, encodeId=74d41e940037a, content=<a href='/topic/show?id=7b3d1630617' target=_blank style='color:#2F92EE;'>#Signal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16306, encryptionId=7b3d1630617, topicName=Signal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sat May 26 17:37:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036183, encodeId=ab822036183db, content=<a href='/topic/show?id=ae7816304dc' target=_blank style='color:#2F92EE;'>#Sign#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16304, encryptionId=ae7816304dc, topicName=Sign)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9ed371, createdName=楚秀娟, createdTime=Mon May 28 13:37:00 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348066, encodeId=3c42134806615, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399146, encodeId=cea6139914671, content=<a href='/topic/show?id=1e7464490b7' target=_blank style='color:#2F92EE;'>#沙门氏菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64490, encryptionId=1e7464490b7, topicName=沙门氏菌)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/dZj08ckjV0K1emuaDxP7G2DicoLPC5gxtjiatZukfCclP1r3RbxcTgibCpicZkfazrzGUU2iatBBWBNuPTP10a3g5Mw/0, createdBy=12552195639, createdName=lifestar, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429860, encodeId=96b4142986060, content=<a href='/topic/show?id=cc2584301d4' target=_blank style='color:#2F92EE;'>#脂多糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84301, encryptionId=cc2584301d4, topicName=脂多糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f354234967, createdName=小刀医生, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569315, encodeId=adad156931531, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315423, encodeId=543b31542322, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue May 15 22:02:51 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315400, encodeId=d2be31540044, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Tue May 15 19:51:37 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315071, encodeId=b7e83150e1da, content=对革兰氏阴性菌表面的脂多糖(lipopolysaccharide.LPS)的修饰可以被用来逃避宿主的免疫反应或产生对抗生素的抗性.例如.降低LPS中脂质A(lipidA)负电荷的修饰能够提高沙门氏菌(Salmonella)对多粘菌素B(polymyxinB)和其它阳离子抗菌素的抗性., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon May 14 18:44:30 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1794003, encodeId=74d41e940037a, content=<a href='/topic/show?id=7b3d1630617' target=_blank style='color:#2F92EE;'>#Signal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16306, encryptionId=7b3d1630617, topicName=Signal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sat May 26 17:37:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036183, encodeId=ab822036183db, content=<a href='/topic/show?id=ae7816304dc' target=_blank style='color:#2F92EE;'>#Sign#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16304, encryptionId=ae7816304dc, topicName=Sign)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9ed371, createdName=楚秀娟, createdTime=Mon May 28 13:37:00 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348066, encodeId=3c42134806615, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399146, encodeId=cea6139914671, content=<a href='/topic/show?id=1e7464490b7' target=_blank style='color:#2F92EE;'>#沙门氏菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64490, encryptionId=1e7464490b7, topicName=沙门氏菌)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/dZj08ckjV0K1emuaDxP7G2DicoLPC5gxtjiatZukfCclP1r3RbxcTgibCpicZkfazrzGUU2iatBBWBNuPTP10a3g5Mw/0, createdBy=12552195639, createdName=lifestar, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429860, encodeId=96b4142986060, content=<a href='/topic/show?id=cc2584301d4' target=_blank style='color:#2F92EE;'>#脂多糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84301, encryptionId=cc2584301d4, topicName=脂多糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f354234967, createdName=小刀医生, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569315, encodeId=adad156931531, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315423, encodeId=543b31542322, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue May 15 22:02:51 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315400, encodeId=d2be31540044, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Tue May 15 19:51:37 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315071, encodeId=b7e83150e1da, content=对革兰氏阴性菌表面的脂多糖(lipopolysaccharide.LPS)的修饰可以被用来逃避宿主的免疫反应或产生对抗生素的抗性.例如.降低LPS中脂质A(lipidA)负电荷的修饰能够提高沙门氏菌(Salmonella)对多粘菌素B(polymyxinB)和其它阳离子抗菌素的抗性., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon May 14 18:44:30 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-16 zhangyxzsh
  7. [GetPortalCommentsPageByObjectIdResponse(id=1794003, encodeId=74d41e940037a, content=<a href='/topic/show?id=7b3d1630617' target=_blank style='color:#2F92EE;'>#Signal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16306, encryptionId=7b3d1630617, topicName=Signal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sat May 26 17:37:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036183, encodeId=ab822036183db, content=<a href='/topic/show?id=ae7816304dc' target=_blank style='color:#2F92EE;'>#Sign#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16304, encryptionId=ae7816304dc, topicName=Sign)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9ed371, createdName=楚秀娟, createdTime=Mon May 28 13:37:00 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348066, encodeId=3c42134806615, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399146, encodeId=cea6139914671, content=<a href='/topic/show?id=1e7464490b7' target=_blank style='color:#2F92EE;'>#沙门氏菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64490, encryptionId=1e7464490b7, topicName=沙门氏菌)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/dZj08ckjV0K1emuaDxP7G2DicoLPC5gxtjiatZukfCclP1r3RbxcTgibCpicZkfazrzGUU2iatBBWBNuPTP10a3g5Mw/0, createdBy=12552195639, createdName=lifestar, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429860, encodeId=96b4142986060, content=<a href='/topic/show?id=cc2584301d4' target=_blank style='color:#2F92EE;'>#脂多糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84301, encryptionId=cc2584301d4, topicName=脂多糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f354234967, createdName=小刀医生, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569315, encodeId=adad156931531, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315423, encodeId=543b31542322, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue May 15 22:02:51 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315400, encodeId=d2be31540044, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Tue May 15 19:51:37 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315071, encodeId=b7e83150e1da, content=对革兰氏阴性菌表面的脂多糖(lipopolysaccharide.LPS)的修饰可以被用来逃避宿主的免疫反应或产生对抗生素的抗性.例如.降低LPS中脂质A(lipidA)负电荷的修饰能够提高沙门氏菌(Salmonella)对多粘菌素B(polymyxinB)和其它阳离子抗菌素的抗性., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon May 14 18:44:30 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-15 changjiu

    学习一下谢谢

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1794003, encodeId=74d41e940037a, content=<a href='/topic/show?id=7b3d1630617' target=_blank style='color:#2F92EE;'>#Signal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16306, encryptionId=7b3d1630617, topicName=Signal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sat May 26 17:37:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036183, encodeId=ab822036183db, content=<a href='/topic/show?id=ae7816304dc' target=_blank style='color:#2F92EE;'>#Sign#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16304, encryptionId=ae7816304dc, topicName=Sign)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9ed371, createdName=楚秀娟, createdTime=Mon May 28 13:37:00 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348066, encodeId=3c42134806615, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399146, encodeId=cea6139914671, content=<a href='/topic/show?id=1e7464490b7' target=_blank style='color:#2F92EE;'>#沙门氏菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64490, encryptionId=1e7464490b7, topicName=沙门氏菌)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/dZj08ckjV0K1emuaDxP7G2DicoLPC5gxtjiatZukfCclP1r3RbxcTgibCpicZkfazrzGUU2iatBBWBNuPTP10a3g5Mw/0, createdBy=12552195639, createdName=lifestar, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429860, encodeId=96b4142986060, content=<a href='/topic/show?id=cc2584301d4' target=_blank style='color:#2F92EE;'>#脂多糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84301, encryptionId=cc2584301d4, topicName=脂多糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f354234967, createdName=小刀医生, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569315, encodeId=adad156931531, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315423, encodeId=543b31542322, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue May 15 22:02:51 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315400, encodeId=d2be31540044, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Tue May 15 19:51:37 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315071, encodeId=b7e83150e1da, content=对革兰氏阴性菌表面的脂多糖(lipopolysaccharide.LPS)的修饰可以被用来逃避宿主的免疫反应或产生对抗生素的抗性.例如.降低LPS中脂质A(lipidA)负电荷的修饰能够提高沙门氏菌(Salmonella)对多粘菌素B(polymyxinB)和其它阳离子抗菌素的抗性., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon May 14 18:44:30 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-15 131****1460

    学习了受益匪浅

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1794003, encodeId=74d41e940037a, content=<a href='/topic/show?id=7b3d1630617' target=_blank style='color:#2F92EE;'>#Signal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16306, encryptionId=7b3d1630617, topicName=Signal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sat May 26 17:37:00 CST 2018, time=2018-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036183, encodeId=ab822036183db, content=<a href='/topic/show?id=ae7816304dc' target=_blank style='color:#2F92EE;'>#Sign#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16304, encryptionId=ae7816304dc, topicName=Sign)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9ed371, createdName=楚秀娟, createdTime=Mon May 28 13:37:00 CST 2018, time=2018-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1348066, encodeId=3c42134806615, content=<a href='/topic/show?id=d61b418860a' target=_blank style='color:#2F92EE;'>#基因表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41886, encryptionId=d61b418860a, topicName=基因表达)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=bioon1, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399146, encodeId=cea6139914671, content=<a href='/topic/show?id=1e7464490b7' target=_blank style='color:#2F92EE;'>#沙门氏菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64490, encryptionId=1e7464490b7, topicName=沙门氏菌)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/dZj08ckjV0K1emuaDxP7G2DicoLPC5gxtjiatZukfCclP1r3RbxcTgibCpicZkfazrzGUU2iatBBWBNuPTP10a3g5Mw/0, createdBy=12552195639, createdName=lifestar, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429860, encodeId=96b4142986060, content=<a href='/topic/show?id=cc2584301d4' target=_blank style='color:#2F92EE;'>#脂多糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84301, encryptionId=cc2584301d4, topicName=脂多糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f354234967, createdName=小刀医生, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569315, encodeId=adad156931531, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Wed May 16 08:37:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315423, encodeId=543b31542322, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Tue May 15 22:02:51 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315400, encodeId=d2be31540044, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Tue May 15 19:51:37 CST 2018, time=2018-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=315071, encodeId=b7e83150e1da, content=对革兰氏阴性菌表面的脂多糖(lipopolysaccharide.LPS)的修饰可以被用来逃避宿主的免疫反应或产生对抗生素的抗性.例如.降低LPS中脂质A(lipidA)负电荷的修饰能够提高沙门氏菌(Salmonella)对多粘菌素B(polymyxinB)和其它阳离子抗菌素的抗性., beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon May 14 18:44:30 CST 2018, time=2018-05-14, status=1, ipAttribution=)]
    2018-05-14 有备才能无患

    对革兰氏阴性菌表面的脂多糖(lipopolysaccharide.LPS)的修饰可以被用来逃避宿主的免疫反应或产生对抗生素的抗性.例如.降低LPS中脂质A(lipidA)负电荷的修饰能够提高沙门氏菌(Salmonella)对多粘菌素B(polymyxinB)和其它阳离子抗菌素的抗性.

    0

相关资讯

J Clin Periodontol:牙龈卟啉单胞菌脂多糖通过NF-κBκ而不是βWnt /β-catenin通路影响牙龈干/祖细胞特征

本研究首次研究牙龈卟啉单胞菌脂多糖(Pg-LPS)对牙龈干/祖细胞(G-MSC)增殖/再生能力的影响。

J Endod:细菌感染时人牙髓细胞表达炎症及硬组织形成相关细胞标志物

脂多糖(LPS)是引起深龋和牙髓炎时革兰阴性菌外膜的主要组成部分。当细菌侵入牙本质小管和牙本质持续受到损伤时,预先存在的成牙本质细胞会形成修复性牙本质。然而,LPS与修复性牙本质的关系还未可知。这篇研究的目的是为了评估LPS刺激是否会诱导人牙髓细胞(hDPCs)的硬组织形成。

Sci Rep:脂多糖引起的永久性鼻炎可引起嗅球胶质增生和突出丧失

因嗅黏膜(OM)暴露在环境物质中,因此很容易遭受炎症侵袭。最近,有研究人员为了调查环境毒物引起的OM炎症对嗅球的影响,在小鼠中诱导了永久性的鼻炎,并且分析了在OM和OB中组织病理变化的空间和时间模式。研究人员将小鼠接受单侧鼻内脂多糖(LPS)注射或者生理盐水注射,每周3次,并且在首次注射后的第1、3、7、14和第21天进行免疫组化分析。研究发现,LPS注射诱导了OM的炎症反应,包括了 Ly-6G-

PLoS One:TLR4的表达水平而非其序列在识别LPS中发挥作用

本研究旨在探究Toll样受体4(TLR4)单核苷酸多态性(SNP)在脂多糖(LPS)识别中的作用,为此,研究人员培养了仅在TLR4序列中不同的小鼠。 研究人员使用细菌人工染色体(BAC)转基因方法和TLR4/MD-2敲除小鼠来特异性探究人类TLR4突变在识别LPS中的作用。结果体外和体内试验研究显示,TLR4的表达水平而不是TLR4的序列在识别LPS,特别是低乙酰化的LPS中发挥更大的作用。原始出

Nature:科学家Nature发文,有望助力新型抗生素研发

全世界范围内,新型抗生素的缺乏已经带来了严重的公共卫生危机,而针对革兰氏阴性菌的抗生素新药研发则一直困难重重。在最新一期的《自然》杂志上,科学家们面对这一难题做出了突破。

Biochem Biophys Res Commun:右美托咪啶通过抑制肺成纤维细胞缝隙连接功能,保护脂多糖诱导的细胞凋亡

背景与目的:α2-肾上腺素受体激动剂右美托咪定对急性肺损伤(ALI)具有保护作用,但其机制还有很多尚不清楚。