Int J Cardiol:妊娠期特发性复发性心包炎的治疗

2019-02-10 xing.T MedSci原创

由此可见,特发性复发性心包炎患者的妊娠一般结局良好,特别是当根据标准化方案对患者进行多学科团队的随访时。

有关妊娠期特发性复发性心包炎的数据很少。近日,血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,该研究旨在评估怀孕期间特发性复发性心包炎的治疗和结局。

研究人员对有特发性心包炎复发史的14名女性的21次妊娠进行了评估(平均孕妇年龄为31.5岁,平均孕龄39.0周),并分为2组:8例妊娠进行回顾性分析(2002-2010),13例(2011-2017)根据预先定义的治疗协议进行前瞻性随访。

十次妊娠平安无事,三次妊娠以自发性早期流产结束,一次妊娠胎儿死亡发生在19周。8次妊娠发生心包炎复发,2例加用NSAID治疗; 5例患者皮质激素剂量增加,2例患者开始/增加使用阿司匹林;扑热息痛是被允许使用的。前瞻性队列中有两例使用秋水仙碱。一名患者发生HELLP综合征,分娩后缓解,一名患者出现动脉高血压和转氨酶升高。所有婴儿均有良好的预后(平均出生体重为3114g,10名男性婴儿)。回顾性队列中的出生体重显著较低(分别为2806g vs. 3320g,p值为0.017),其中使用较高剂量的皮质类固醇(中位剂量分别为10.0mg vs. 2.5mg,p值为0.048)。分娩后发生5次心包炎复发,标准治疗后缓解。

由此可见,特发性复发性心包炎患者的妊娠一般结局良好,特别是当根据标准化方案对患者进行多学科团队的随访时。

原始出处:

AntonioBrucato,et al.Management of idiopathic recurrent pericarditis during pregnancy.International Journal of Cardiology.2019.https://doi.org/10.1016/j.ijcard.2019.02.003

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