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IJLH：细胞凋亡可以作为儿童急性髓系白血病高风险表型的生物标志物?

2019-06-02 不详 网络

细胞凋亡
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已经有研究在急性髓性白血病（AML）中探索了细胞凋亡的调节异常；然而，它与儿科AML临床结果的相关性尚不清楚。本研究旨在分析儿童AML患者通过内在途径介导的细胞凋亡和凋亡百分比以及临床结果。 本前瞻性研究纳入2013年7月至2016年8月登记的儿童AML患者。流式细胞仪检测基线骨髓(BM)中Annexin‐V(总凋亡标志物)和caspase‐9(内在通路标志物)的表达，并与对照组(未受实体瘤

已经有研究在急性髓性白血病（AML）中探索了细胞凋亡的调节异常；然而，它与儿科AML临床结果的相关性尚不清楚。本研究旨在分析儿童AML患者通过内在途径介导的细胞凋亡和凋亡百分比以及临床结果。

本前瞻性研究纳入2013年7月至2016年8月登记的儿童AML患者。流式细胞仪检测基线骨髓(BM)中Annexin‐V(总凋亡标志物)和caspase‐9(内在通路标志物)的表达，并与对照组(未受实体瘤影响的BM和未受影响的同胞外周血[PB]进行比较。使用log‐rank测试比较总体生存期(OS)和无事件生存期(EFS)。

本研究共纳入151例AML患者，中位年龄10岁(范围:0.7‐18岁)。AML患者中Annexin‐V的表达明显高于实体瘤患者的BM (P = 0.01)和健康患者的PB (P = 0.04)。Caspase‐9在胚细胞中的表达无显著差异。在WBC计数≥11000 /mm3 (P = 0.02)、‐细胞遗传学不良(P = 0.02)、RUNX1‐RUNX1T1易位缺失(P = 0.004)和NPM1突变缺失(P = 0.05)的患者中，annexin‐V的中位表达显著增高。高annexin‐V表达的患者在单因素分析中OS明显低于对照组(P = 0.05)，而在多因素分析中则无差异(P = 0.32)。

研究表明，急性髓系白血病(AML)基线BM标本中细胞凋亡总体呈激活状态。在该疾病中，高凋亡可能与高风险表型有关。

原始出处：

Anudishi Tyagi, Raja Pramanik,Apoptosis: A biomarker of high‐risk phenotype in pediatric acute myeloid leukemia?

本文系梅斯医学（MedSci）原创编译整理，转载需授权！

 

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    2019-10-16 fangcong

    #髓系白血病#

    0

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    2019-07-06 zlawrance

    #高风险#

    0

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    2020-02-02 智者为医08

    #标志物#

    0

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    2019-06-04 ms8538335253054589

    #细胞凋亡#

    0

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    2019-06-04 tastas

    #表型#

    0

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    2019-06-04 zhu_jun9842

    #生物标志#

    0

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    2019-06-04 zhu_jun9842

    #生物标志#

    0

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