Cell Res:间歇节食有助于减肥

2017-10-19 MedSci MedSci原创

加拿大疾病儿童医院Hoon-Ki Sung课题组找到了“瑜伽禁食”、“道家辟谷”益于保持体形的生物基础,文章作者Kyoung-Han Kim和Yun Hye Kim的研究证明,间歇性禁食有助于小鼠启动新陈代谢,提高体温燃烧脂肪。 不健康的饮食习惯、久坐等不良生活方式与许多代谢疾病有关,如糖尿病、心脏病和肥胖症。根据最新研究,间歇性禁食,例如断食疗法,有助于这些情况的治疗。 研究小组希望在分子水

加拿大疾病儿童医院Hoon-Ki Sung课题组找到了“瑜伽禁食”、“道家辟谷”益于保持体形的生物基础,文章作者Kyoung-Han Kim和Yun Hye Kim的研究证明,间歇性禁食有助于小鼠启动新陈代谢,提高体温燃烧脂肪。

不健康的饮食习惯、久坐等不良生活方式与许多代谢疾病有关,如糖尿病、心脏病和肥胖症。根据最新研究,间歇性禁食,例如断食疗法,有助于这些情况的治疗。

研究小组希望在分子水平上细致了解禁食触发了哪些反应。

长达16周内,让实验小鼠经历“进食两天,断食一天”的循环治疗,总卡路里摄入不经调整。4个月后,对比摄入相同食物数量的对照组小鼠,禁食组小鼠体重减轻。

体重下降并不是唯一好处。在高脂食谱中,这种短周期禁食能减少小鼠体内“有害”的白色脂肪,增加“有益”的棕色脂肪。小鼠血糖和胰岛素系统也更加稳定。

进一步实验表明,这种益处在禁食的第六周即可显现。

通过基础生物学分析,研究人员发现间歇性禁食使脂肪产生免疫反应,免疫系统和炎症反应的某些基因通路发生了变化,一种在抗炎症反应中起重要作用的白细胞被激发了。这种抗炎巨噬细胞刺激脂肪细胞燃烧储存的脂质或脂肪来促进产热。

在禁食期间,由于血管生长因子(vascular growth factor,VEGF)水平上调,帮助了抗炎巨噬细胞激活以及血管形成。

“在不减少卡路里摄入的前提下,间歇性禁食可以预防和治疗肥胖和代谢性疾病,”Kyoung-Han Kim说。

“更引人注目的是,单次24小时为周期的断食就能刺激血管细胞生长变化,以及之后的免疫变化。当小鼠再次禁食时,情况则立即发生反转。”Yun Hye Kim补充道。

原文检索:

Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage  Cell Research advance online publication 17 October 2017; doi: 10.1038/cr.2017.126

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    2018-02-20 维他命
  4. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Fri Oct 20 12:12:03 CST 2017, time=2017-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254475, encodeId=a51b2544e539, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Oct 20 07:11:52 CST 2017, time=2017-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254471, encodeId=d4d02544e1ff, content=学习一下谢谢分享, 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    2017-10-21 lsndxfj
  5. 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    2017-10-21 Drhzm308

    谢谢.学习了

    0

  6. 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GetPortalCommentsPageByObjectIdResponse(id=254449, encodeId=7bb72544490e, content=阅读.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Fri Oct 20 06:39:17 CST 2017, time=2017-10-20, status=1, ipAttribution=)]
    2017-10-20 1e0ece0dm09(暂无匿称)

    谢谢

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Fri Oct 20 12:12:03 CST 2017, time=2017-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254475, encodeId=a51b2544e539, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Oct 20 07:11:52 CST 2017, time=2017-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254471, encodeId=d4d02544e1ff, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Fri Oct 20 07:07:06 CST 2017, time=2017-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254466, encodeId=f43025446630, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Fri Oct 20 07:02:01 CST 2017, time=2017-10-20, status=1, ipAttribution=), 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    2017-10-20 明月清辉

    谢谢分享.学习了

    0

  8. 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    2017-10-20 三生有幸9135

    学习一下谢谢分享

    0

  9. 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    2017-10-20 榄枷檬

    学习学习

    0

  10. 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    2017-10-20 刘煜

    阅读.谢谢分享

    0

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