Cancer Prev Res:二甲双胍可能还能降低糖尿病患者的肺癌风险

2015-02-03 MedSci MedSci原创

最新研究指出,对于不吸烟的糖尿病患者,降糖药二甲双胍的作用不仅能够控制血糖,还能降低肺癌的患病率。研究结果发表在最新一期美国癌症研究协会旗下的Cancer Prevention Research杂志上。该项研究由加利福尼亚洲奥克兰市Kaiser Permanente研究部科学家Lori Sakoda博士主持。“一些实验室研究和观察性研究提示,二甲双胍可能具有预防癌症的作用。然而,” Lori Sa

最新研究指出,对于不吸烟的糖尿病患者,降糖药二甲双胍的作用不仅能够控制血糖,还能降低肺癌的患病率。研究结果发表在最新一期美国癌症研究协会旗下的Cancer Prevention Research杂志上。该项研究由加利福尼亚洲奥克兰市Kaiser Permanente研究部科学家Lori Sakoda博士主持。“一些实验室研究和观察性研究提示,二甲双胍可能具有预防癌症的作用。然而,” Lori Sakoda博士指出,“从人类身上研究的数据来看,这却是相互矛盾的。因此,研究人员进行了这项研究,进一步阐明使用二甲双胍和肺癌发病风险之间的联系。”Sakoda和他的同事对47351名糖尿病患者(其中男性占54% )进行了一项回顾性队列研究。该群患者年龄为40岁或以上,均在1994年和1996年之间完成了健康相关信息调查。他们的糖尿病药物使用记录被药房的电子记录所收集。记录中在六个月期间使用两个或两个以上的二甲双胍处方的患者,被定义为二甲双胍“终身使用者”,约占总人数的46%。在15年的随访中,总共有747名患者被诊断出患有肺癌,其中80名为不吸烟者,而203名当时是吸烟者。研究结果发现,二甲双胍

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2045551, encodeId=382e204555115, content=<a href='/topic/show?id=f6cf8225325' target=_blank style='color:#2F92EE;'>#肺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82253, encryptionId=f6cf8225325, topicName=肺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Thu Feb 05 06:00:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061454, encodeId=56d22061454a0, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Tue Nov 10 17:00:00 CST 2015, time=2015-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16702, encodeId=d80716e0274, content=不错的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Sun Feb 22 09:22:00 CST 2015, time=2015-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16265, encodeId=98e41626584, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=da6b7222, createdName=chinayinhan, createdTime=Tue Feb 17 01:06:00 CST 2015, time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473852, encodeId=494614e385229, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Thu Feb 05 12:00:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15076, encodeId=11c5150e656, content=评价比较客观, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Thu Feb 05 00:04:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15050, encodeId=202c15050a7, content=神奇的都是经典, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=61.148.243.**, createdTime=Wed Feb 04 11:05:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15033, encodeId=8c8f15033e1, content=二甲双胍马上要和阿司匹林一样神奇了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160701/IMG57766D0F679469828.jpg, createdBy=d47d28603, createdName=200750383, createdTime=Tue Feb 03 23:57:00 CST 2015, time=2015-02-03, status=1, ipAttribution=)]
    2015-11-10 sjq027
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    2015-02-22 orthoW

    不错的文章,学习了

    0

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    2015-02-17 chinayinhan

    已阅

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=2045551, encodeId=382e204555115, content=<a href='/topic/show?id=f6cf8225325' target=_blank style='color:#2F92EE;'>#肺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82253, encryptionId=f6cf8225325, topicName=肺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Thu Feb 05 06:00:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061454, encodeId=56d22061454a0, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Tue Nov 10 17:00:00 CST 2015, time=2015-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16702, encodeId=d80716e0274, content=不错的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Sun Feb 22 09:22:00 CST 2015, time=2015-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16265, encodeId=98e41626584, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=da6b7222, createdName=chinayinhan, createdTime=Tue Feb 17 01:06:00 CST 2015, time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473852, encodeId=494614e385229, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Thu Feb 05 12:00:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15076, encodeId=11c5150e656, content=评价比较客观, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Thu Feb 05 00:04:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15050, encodeId=202c15050a7, content=神奇的都是经典, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=61.148.243.**, createdTime=Wed Feb 04 11:05:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15033, encodeId=8c8f15033e1, content=二甲双胍马上要和阿司匹林一样神奇了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160701/IMG57766D0F679469828.jpg, createdBy=d47d28603, createdName=200750383, createdTime=Tue Feb 03 23:57:00 CST 2015, time=2015-02-03, status=1, ipAttribution=)]
    2015-02-05 lovetcm

    评价比较客观

    0

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    2015-02-04 61.148.243.**

    神奇的都是经典

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2045551, encodeId=382e204555115, content=<a href='/topic/show?id=f6cf8225325' target=_blank style='color:#2F92EE;'>#肺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82253, encryptionId=f6cf8225325, topicName=肺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Thu Feb 05 06:00:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061454, encodeId=56d22061454a0, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Tue Nov 10 17:00:00 CST 2015, time=2015-11-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16702, encodeId=d80716e0274, content=不错的文章,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f2fb1607679, createdName=orthoW, createdTime=Sun Feb 22 09:22:00 CST 2015, time=2015-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=16265, encodeId=98e41626584, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=da6b7222, createdName=chinayinhan, createdTime=Tue Feb 17 01:06:00 CST 2015, time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473852, encodeId=494614e385229, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Thu Feb 05 12:00:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15076, encodeId=11c5150e656, content=评价比较客观, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Thu Feb 05 00:04:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15050, encodeId=202c15050a7, content=神奇的都是经典, beContent=null, objectType=article, channel=null, level=null, likeNumber=172, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=61.148.243.**, createdTime=Wed Feb 04 11:05:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15033, encodeId=8c8f15033e1, content=二甲双胍马上要和阿司匹林一样神奇了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160701/IMG57766D0F679469828.jpg, createdBy=d47d28603, createdName=200750383, createdTime=Tue Feb 03 23:57:00 CST 2015, time=2015-02-03, status=1, ipAttribution=)]
    2015-02-03 200750383

    二甲双胍马上要和阿司匹林一样神奇了?

    0

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