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Diabetologia：在NOD小鼠抗cd20治疗后，表型明显的抗胰岛素B细胞在胰岛重新增殖？

2019-12-24 MedSci MedSci原创

抗胰岛素B细胞
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自身反应性B细胞逃避免疫耐受是1型糖尿病的发病机制之一。虽然总体B细胞耗竭是一种成功的自体免疫性疾病的治疗方法，但在自体免疫性糖尿病的治疗过程中，自体反应细胞的命运仍是未知的。我们的目的是识别和跟踪胰岛中的抗胰岛素B细胞，并了解它们在抗cd20治疗后的再增殖情况。

自身反应性B细胞逃避免疫耐受是1型糖尿病的发病机制之一。虽然总体B细胞耗竭是一种成功的自体免疫性疾病的治疗方法，但在自体免疫性糖尿病的治疗过程中，自体反应细胞的命运仍是未知的。我们的目的是识别和跟踪胰岛中的抗胰岛素B细胞，并了解它们在抗cd20治疗后的再增殖情况。

研究人员研发了双转基因系统，即VH125.hCD20 / NOD小鼠。 将表达抗胰岛素B细胞频率增加的VH125转基因小鼠与人CD20（hCD20）转基因小鼠杂交，以促进使用抗CD20的B细胞耗竭。 使用多参数和ImageStream流式细胞仪分析B细胞。

研究证明了抗胰岛素B细胞在VH125疾病进展过程中被招募到胰腺。基于CD19的表达，我们在胰岛中发现了两个不同的抗胰岛素B细胞群，它们都富集于CD138int片段。血浆细胞CD138hi部分未检测到抗胰岛素B细胞，CD138hi部分也表达了转录因子Blimp-1。抗cd20治疗后，抗胰岛素B细胞比非特异性B细胞更早的在胰岛重新增殖。重要的是，CD138胰岛素+ CD19-群体特别富集，可能导致在抗CD20治疗后某些小鼠中仍观察到疾病的持续存在。

因此，本研究揭示了为什么抗cd20治疗人类1型糖尿病后c肽的丢失只是暂时延迟的原因。

原始出处：

Joanne Boldison，Larissa C. Da Rosa，Phenotypically distinct anti-insulin B cells repopulate pancreatic islets after anti-CD20 treatment in NOD mice

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    2020-04-09 ms9608593228839890

    #DIA#

    0

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    2020-07-18 baoya

    #胰岛#

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    2020-03-30 ms5439512287675881

    #BET#

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    2020-06-29 aliceclz

    #CD20#

    0

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    2019-12-26 xiaoyeshuang

    #B细胞#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1639289, encodeId=08a916392894f, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Thu Apr 09 16:22:00 CST 2020, time=2020-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1750120, encodeId=04a21e5012038, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Sat Jul 18 06:22:00 CST 2020, time=2020-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1761259, encodeId=249f1e6125970, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Mon Mar 30 02:22:00 CST 2020, time=2020-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943799, encodeId=00ca1943e9946, content=<a href='/topic/show?id=44ca428e60' target=_blank style='color:#2F92EE;'>#CD20#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4287, encryptionId=44ca428e60, topicName=CD20)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfa6343, createdName=aliceclz, createdTime=Mon Jun 29 13:22:00 CST 2020, time=2020-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1273332, encodeId=e3d812e33325d, content=<a href='/topic/show?id=310d383ef5' target=_blank style='color:#2F92EE;'>#B细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3837, encryptionId=310d383ef5, topicName=B细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Thu Dec 26 04:22:00 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535248, encodeId=c54a1535248df, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Thu Dec 26 04:22:00 CST 2019, time=2019-12-26, status=1, ipAttribution=)]
    2019-12-26 tastas

    #表型#

    0