Heart:BAV患者更易出现颅内动脉瘤

2017-09-18 MedSci MedSci原创

二叶主动脉瓣(BAV)是一种常见的先天性心脏病,长期不治疗可引起动脉瘤,包括颅内动脉瘤。近日,在国际心血管权威杂志《Heart》上发表了一篇旨在评估BAV患者颅内动脉瘤的发生率和预后的临床研究。本研究纳入了1994年至2013年在梅奥诊所行头颅磁共振的BAV患者,并回顾分析其临床资料。最终共纳入678名患者,平均年龄是57±13岁,男性占71%(480名),平均随访时间是10±3年。结果表明,有1

二叶主动脉瓣(BAV)是一种常见的先天性心脏病,长期不治疗可引起动脉瘤,包括颅内动脉瘤。近日,在国际心血管权威杂志《Heart》上发表了一篇旨在评估BAV患者颅内动脉瘤的发生率和预后的临床研究。

本研究纳入了1994年至2013年在梅奥诊所行头颅磁共振的BAV患者,并回顾分析其临床资料。最终共纳入678名患者,平均年龄是57±13岁,男性占71%(480名),平均随访时间是10±3年。结果表明,有154名患者出现有主动脉缩窄(COA),有52名患者共出现59例颅内动脉瘤(7.7%),主动脉缩窄患者中有20名患者存在颅内动脉瘤(12.9%),无主动脉缩窄患者中有32名出现颅内动脉瘤(5.7%)(p<0.001)。在没有COA的患者中,女性和左右腱索融合是颅内动脉瘤发生的危险因素(HR 1.76, CI 1.31 - 2.68, p=0.03)。在52名出现有颅内动脉瘤的患者中,3名患者动脉瘤有扩大(6%),2名患者出现动脉瘤破裂(4%),4名患者接受了弹簧圈栓塞治疗(8%),对于626名没有颅内动脉瘤的患者,随访期间也没有出现新发的颅内动脉瘤。

研究结果表明,二叶主动脉瓣患者更易出现颅内动脉瘤,并且主动脉缩窄、左右腱索融合和女性性别可能是颅内动脉瘤的高危因素。

原始出处:

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1356508, encodeId=4da3135650847, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Sep 20 06:37:00 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562695, encodeId=797e1562695c4, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Sep 20 06:37:00 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245631, encodeId=ef0c245631be, content=感谢小编为我们准备了如此丰盛的精神大餐.同时也向作者致谢!认真学习了.点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Sep 19 09:23:27 CST 2017, time=2017-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245392, encodeId=bb662453927d, content=学习啦!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Mon Sep 18 18:50:51 CST 2017, time=2017-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245359, encodeId=18b42453597d, content=控制血压.避免劳累激动, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Mon Sep 18 16:47:33 CST 2017, time=2017-09-18, status=1, ipAttribution=)]
    2017-09-20 zhaojie88
  2. [GetPortalCommentsPageByObjectIdResponse(id=1356508, encodeId=4da3135650847, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Sep 20 06:37:00 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562695, encodeId=797e1562695c4, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Sep 20 06:37:00 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245631, encodeId=ef0c245631be, content=感谢小编为我们准备了如此丰盛的精神大餐.同时也向作者致谢!认真学习了.点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Sep 19 09:23:27 CST 2017, time=2017-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245392, encodeId=bb662453927d, content=学习啦!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Mon Sep 18 18:50:51 CST 2017, time=2017-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245359, encodeId=18b42453597d, content=控制血压.避免劳累激动, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Mon Sep 18 16:47:33 CST 2017, time=2017-09-18, status=1, ipAttribution=)]
    2017-09-20 slcumt
  3. [GetPortalCommentsPageByObjectIdResponse(id=1356508, encodeId=4da3135650847, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Sep 20 06:37:00 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562695, encodeId=797e1562695c4, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Sep 20 06:37:00 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245631, encodeId=ef0c245631be, content=感谢小编为我们准备了如此丰盛的精神大餐.同时也向作者致谢!认真学习了.点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Sep 19 09:23:27 CST 2017, time=2017-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245392, encodeId=bb662453927d, content=学习啦!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Mon Sep 18 18:50:51 CST 2017, time=2017-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245359, encodeId=18b42453597d, content=控制血压.避免劳累激动, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Mon Sep 18 16:47:33 CST 2017, time=2017-09-18, status=1, ipAttribution=)]
    2017-09-19 lietome24

    感谢小编为我们准备了如此丰盛的精神大餐.同时也向作者致谢!认真学习了.点赞!

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1356508, encodeId=4da3135650847, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Sep 20 06:37:00 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562695, encodeId=797e1562695c4, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Sep 20 06:37:00 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245631, encodeId=ef0c245631be, content=感谢小编为我们准备了如此丰盛的精神大餐.同时也向作者致谢!认真学习了.点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Sep 19 09:23:27 CST 2017, time=2017-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245392, encodeId=bb662453927d, content=学习啦!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Mon Sep 18 18:50:51 CST 2017, time=2017-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245359, encodeId=18b42453597d, content=控制血压.避免劳累激动, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Mon Sep 18 16:47:33 CST 2017, time=2017-09-18, status=1, ipAttribution=)]
    2017-09-18 tanxingdoctor

    学习啦!谢谢分享!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1356508, encodeId=4da3135650847, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Wed Sep 20 06:37:00 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562695, encodeId=797e1562695c4, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Wed Sep 20 06:37:00 CST 2017, time=2017-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245631, encodeId=ef0c245631be, content=感谢小编为我们准备了如此丰盛的精神大餐.同时也向作者致谢!认真学习了.点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eb131638261, createdName=lietome24, createdTime=Tue Sep 19 09:23:27 CST 2017, time=2017-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245392, encodeId=bb662453927d, content=学习啦!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Mon Sep 18 18:50:51 CST 2017, time=2017-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=245359, encodeId=18b42453597d, content=控制血压.避免劳累激动, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Mon Sep 18 16:47:33 CST 2017, time=2017-09-18, status=1, ipAttribution=)]
    2017-09-18 楠博One

    控制血压.避免劳累激动

    0

相关资讯

JACC:代谢正常肥胖患者的心血管疾病发生风险依旧更高

目前,对于代谢正常的肥胖患者的心血管危险因素尚未阐明。近日,在国际心血管权威杂志JACC上发表了一篇旨在评估代谢正常的肥胖患者与4种不同的心血管疾病发生之间相关性的临床研究。本研究纳入了1995年至2015年美国电子数据库的350万名研究对象,年龄均在18岁及以上,并且最开始均无心血管疾病史。通过体重指数(BMI),将所有研究对象分成不同组别,包括低体重、正常体重、超重和肥胖,并根据代谢类型分成糖

JACC:搭桥vsPCI—伴1型糖尿病心血管疾病患者治疗的选择

对于伴有多支血管病变的1型糖尿病(T1D)患者,搭桥手术或者经皮冠脉介入治疗(PCI)的收益哪种更大尚未阐明。本研究纳入了瑞典1995年至2013年行首次多血管重建手术的T1D患者,并通过多个数据库对患者的临床信息和预后进行全面的评估分析。最终,共纳入了683名接受搭桥手术治疗的患者和1863名接受PCI治疗的患者,经过平均10.6年时间的随访,搭桥治疗组的53%患者和PCI治疗组的45%患者死亡

JACC:左房纤维化会增加房颤患者心脑血管不良事件发生风险

左房纤维化严重程度是房颤患者消融成功的关键因素之一,并与患者的卒中、高血压和心衰病史呈相关性。然而,严重的左房纤维化是否会增加房颤患者的主要心脑血管不良事件(MACCE)尚属未知。本回顾性研究纳入了2007年1月至2015年6月1228名行心脏磁共振检查左房纤维化程度的房颤患者,根据严重程度对其进行分组,并随访评估其MACCE发生的概率,包括卒中或短暂性脑缺血发作(TIA)、心梗、急性失代偿心衰或

JACC:不应过早放弃心肺复苏过程中出现喘气症状的患者

"喘"是心肺复苏过程中人体为了增大吸氧量和循环量的自然反应。近日,在国际心血管权威杂志JACC上发表了一篇旨在评估院外心脏停搏出现喘气症状与患者1年生存预后关系的临床研究。本研究纳入搜集了2007年8月至2009年7月院外心脏停搏多中心随机对照研究中出现喘气症状的患者,患者1年后生存预后神经功能良好的标准为脑功能评分(CPC)≤2分。最终结果显示,CPC≤2分的患者占所有患者的5.4%(98/18

盘点:2017上半年关于万能咖啡的研究

近年来,研究人员发现,咖啡中的一些物质有望帮助降低患2型糖尿病的风险,但这些物质很少在动物模型中被测试过。近日发表在Journal of Natural Products杂志上题为“Cafestol, a Bioactive Substance in Coffee, Has Antidiabetic Properties in KKAy Mice”的研究中,奥胡斯大学医院的科学家们报告了其中一种先

JACC:PSCK9可作为房颤患者心血管不良事件发生的预测因子

既往研究证实可溶性蛋白转化酶枯草溶菌素9(PCSK9)可作为高风险心血管疾病患者的心血管事件(CVEs)发生的预测因子,然而,对于房颤患者,PCSK9的预测效果如何尚未阐明。本研究纳入了907名接受维生素K抗凝治疗的房颤患者,对其CVEs进行评估,包括致死性或非致死性心梗、缺血性卒中和心源性死亡。入院时,对患者的PCSK9和血小板激活的标志物-尿11脱氢血栓素B2((11-dh-TxB2)水平进行