NEW ENGL J MED:两篇研究揭示:糖尿病患者数量上升的根源!

2017-04-13 菰逸晓玮 Medicalxpress

【糖尿病继续不断上升】两项关于糖尿病的新研究提供了好消息,但总体来说,血糖仍然是公共卫生负担的重中之重。第一项研究研究了美国儿童1型和2型糖尿病的发病情况,发现了这一令人不安的趋势:从2002年到2012年,两种糖尿病的发病率都有所上升,特别是种族和少数民族。但在第二项研究中提出了一点希望:瑞典研究人员报告说:“两种类型的糖尿病患者心脏病和中风的发生率都有所下降”。美国糖尿病协会首席科学,医学和任

两项关于糖尿病的新研究提供了好消息,但总体来说,血糖仍然是公共卫生负担的重中之重。

第一项研究研究了美国儿童1型和2型糖尿病的发病情况,发现了这一令人不安的趋势:从2002年到2012年,两种糖尿病的发病率都有所上升,特别是种族和少数民族。

但在第二项研究中提出了一点希望:瑞典研究人员报告说:“两种类型的糖尿病患者心脏病和中风的发生率都有所下降”。

美国糖尿病协会首席科学,医学和任务官员William Cefalu博士说:“这些研究强调了我们对糖尿病患病率日益增长的担忧,每23秒,一人在美国被诊断患有糖尿病”。

Cefalu补充说:“瑞典的研究令人鼓舞,表明事情正在朝着正确的方向前进”。由于糖尿病研究,我们已经能够改善世界各地数以百万计的糖尿病患者的生活,但疾病依然存在我们还有很多工作要做。

根据ADA,在美国,约有2900万人患有糖尿病,绝大多数患有2型糖尿病。约有130万人患有1型糖尿病。

在2型糖尿病患者中,身体不能正确使用胰岛素,这被称为胰岛素抵抗。胰岛素是一种激素,有助于将糖从食物引入人体的细胞中,作为燃料。当有人患有2型糖尿病时,这个过程不能正常运行,血糖水平上升。肥胖是2型糖尿病的主要危险因素,尽管它不是该疾病的唯一因素。

1型糖尿病是一种自身免疫性疾病。身体的免疫系统错误地攻击了胰腺中产生胰岛素的细胞。这使得1型糖尿病患者几乎没有胰岛素。为了保持活力,1型糖尿病患者必须通过注射来代替胰岛素。

关于糖尿病发病率研究的作者Elizabeth Mayer-Davis解释说:“导致2型糖尿病的具体基因和环境/行为因素与引起1型糖尿病的具体基因和环境/行为因素不同”。

Mayer-Davis及其同事发现,1型糖尿病每年增加1.8%。西班牙裔儿童的增长明显增加,每年为4.2%。相比之下,白人儿童为1.2%。

她说:“增加的因素还不完全清楚”。

尽管儿童患有2型糖尿病的人数却少于1型,但从2002年到2012年,2型糖尿病患病率每年上升了4.8%。黑人2型糖尿病年均增长6.3%。调查人员发现,对于亚太岛民来说,年增长率为8.5%,美洲原住民人数几乎达到9%。

Mayer-Davis说:“2型糖尿病的发病率有可能与青少年超重和肥胖的增加有关,尽管这不是唯一的原因”。

第二项研究着眼于1998年至2012年在瑞典国家数据库中注册的所有人员,并在2014年之前健康。数据库中有近3.7万人患有1型糖尿病,超过45.7万人患有2型糖尿病。将这些患者与没有糖尿病的类似人群(“对照组”)进行比较。

与匹配的对照相比,研究人员发现1型糖尿病患者的心脏病和中风大大减少了40%。研究显示,在2型糖尿病患者中,与对照组相比,心脏病和中风大幅下降了20%。

在研究期间死亡时,与对照组相比,1型糖尿病患者的死亡人数相似。研究人员发现,类型2的人与对照组相比死亡人数减少。

研究作者指出,即使有这些改善,任何一种类型的糖尿病患者仍然有比对照组更高的总体过早死亡和心脏病发病率。

研究作者Aidin Rawshani博士说:“我们认为我们研究中观察到的变化很可能反映了糖尿病患者临床护理进展的结合。他来自瑞典哥德堡大学医学研究所。

他说:“也许最重要的是改善血管危险因素的管理”。这些危险因素包括高血压胆固醇异常,肾损害早期症状和血糖控制不良。他说:“用高血压药物和降胆固醇药物治疗可能有助于改善”。

这两项研究都在4月13日公布在NEW ENGL J MED上。

原始出处:

1. Aidin Rawshani, Araz Rawshani, Stefan Franzén,et al. Mortality and Cardiovascular Disease in Type 1 and Type 2 Diabetes. NEW ENGL J MED. 2017 Apr 13.

2. Elizabeth J. Mayer-Davis, Jean M. Lawrence, Dana Dabelea,et al. Incidence Trends of Type 1 and Type 2 Diabetes among Youths, 2002–2012. NEW ENGL J MED. 2017 Apr 13.

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    2018-02-26 zhaojie88
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    2017-04-21 1e10c84am36(暂无匿称)

    文章不错,拜读了

    0

  4. 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    2017-04-18 lou.minghong

    生活方式疾病?

    0

  5. 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  6. 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  7. 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    2017-04-15 绛珠草小姐

    谢谢分享,学习了

    0

  8. 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    2017-04-15 大爰

    难以根治的顽疾!

    0

  9. 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    2017-04-14 春暖花开8785

    糖尿病成了危害人类健康的重要疾病之一

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=187306, encodeId=6ebc18e306c5, content=糖尿病发病率为什么越来越高?还有,现在的病人怎么越来越多了?, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/04/24/1c2dbd6706e64df33befd6663f1d6b37.jpg, createdBy=94f61661779, createdName=lyh994, createdTime=Fri Apr 14 09:34:28 CST 2017, time=2017-04-14, status=1, ipAttribution=)]
    2017-04-14 lyh994

    糖尿病发病率为什么越来越高?还有,现在的病人怎么越来越多了?

    0

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