二甲双胍通过miRNA抑制胰腺癌干细胞，治疗胰腺癌

主要论文：
1. Gastroenterology, 2000; 18(4) Suppl:A654 Sci收录
Effects and mechanisms of somatostatin and its analogues on apoptosis of pancreatic acinar cells in acute pancreatitis in mice.
2. Gastroenterology, 2002; 122(4) Suppl: A552 Sci收录
Study on the function of pharynx and upper esophageal sphincter in globus sensation.
3. J Gastroenterol Hepatol, 2000; 15 (suppl): A255 Sci收录
The effect of Cisapride on colonic transit time in patients with chronic functional constipation.

Pancreas, 2003;27(4):424-426 Sci收录
1. Investigating the expression of Transforming growth factorβ1 and decorin in freshly isolated and primary cultured rat pancreatic stellate cells
2. The association of free radicals and pancreatic stellate cells in the pathogenesis of chronic pancreatitis.
3. Hepatic growth factor attenuate experimental acute pancreatitis in mice through affecting arachidonic acid metabolism.
4. Effect of hepatic growth factor on acinar cell apoptosis in experimental acute pancreatitis in mice.
5. Immunohistochemical study of p53, caspase-7 and bcl-2/bax in pancreatic cancer and chronic pancreatitis.
6. The effect of caspase inhibitor Z-VAD-FMK on the all-trans retinoic acid –induced apoptosis in pancreatic cancer cells.
7. Kanglaite, an acetone extract of the Coix seed, inhibits proliferation of human pancreatic cancer cells via cell cycle arrest and apoptosis.

Gastroenterology, 2003;124(4) Sci收录
1. Tegaserod provides rapid, effective relief of abdominal pain/ discomport bloating and constipation in Chinese patients with irritable bowel syndrome with constipation.
2. Heptocyte growth factor attenuate pancreatic damage in cerulean-induced acute pancreatitis in mice.
3. All-trans retinoic acid-induced apoptosis in pancreatic cancer cells is mediated by bcl-2/bax and p53 expression.
4. Efficacy of Rabeprazole versus Omeprazole for acid suppression in patients with duodenal ulcer: a multicenter, randomized,double-blind clinical trial.
5. Role of mast cells in rectal hypersensitivity induced by acute stress in rats.
6. Repeated intrarectally actetic-acid irritation in neonatal rats induced rectal hypersensitivity in adult rats.
Gut, 2003;Supplement Sci收录
Functional brain imaging in irritable bowel syndrome with rectal balloon-distention in Chinese subjects.
Gut, 2004; 53(suppl) Sci收录
1.Neutral lipid isolated from endosperm of job’s tears inhibits the growth of PATU-8988 cells via apoptosis, G2/M arrest, and regulation of gene expression
2.The effect of tumor necrosis factor receptor-p55/-p75 in pathogenesis of severe acute pancreatitis.
3.Thymosin alpha 1 as an immune interferer attenuates the severity of severe acute pancreatitis in rats.
4.The involvement of voltage-gated sodium channels in visceral hypersensitivity in a rat model of IBS.
J Gastroen Hepatol,2004,19(suppl) Sci收录
The effect of histone H3 acetylation on the cell cycle arrest induced by
all-trans retinoic acid in pancreatic cancer cells
2.Construction and identification of recombinant adenovirus carrying vasostatin gene.

主编专著：
1. 《胰腺病学新进展与新技术》 上海科学技术文献出版社 2000
2. 《肠易激综合征》 上海科学技术文献出版社 2002
3. 《消化系疾病临床新技术》 人民军医出版社 2002
4. 《舒斯特胃肠动力学》（主译） 上海科学技术文献出版社 2003
　　
承担课题：
1、胰腺纤维化发病机制及小柴胡汤抗纤维化的研究
　　2001.10-2004.10 　上海市自然科学基金(014119074) 4万
2、急性胰腺炎细胞凋亡机制及其治疗新策略研究
　　2000.5-2003.6　　上海市科委基金（0021214028）4万
3、TGFβ1及胰腺星状细胞在胰腺纤维化中的作用
　　2001.9-2003.9　　上海市科委基金（012B14026）5万
4、急性胰腺炎加重及凋亡机制诱导作用的研究
2002.9-2005.9　　上海市科委重点科技项目（02DJ14039）25万

“急性重症胰腺炎及中西医结合治疗实验研究”2000年获得上海市科技进步三等奖
　　（证书号：003161）