Heart:城市化和海拔高度对高血压发病率及其危险因素的影响

2017-01-25 xing.T MedSci原创

这些研究结果表明进展为高血压的异质性主要取决于城市化进程和研究区域的海拔高度。

有关低收入和中等收入国家高血压负担的数据大多来自于横断面调查,而不是纵向研究。近日,在心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员估计了4个不同城市化程度和海拔高度研究地点高血压的发病率和危险因素。

该研究所用的分析数据来自于CRONICAS队列研究,CRONICAS研究是在秘鲁的城市、半城市化地区和农村中进行的。从每个地区最新的人口普查数抽取据按照年龄性别分层的随机化样本作为研究的参与者。高血压被定义为收缩压≥ 140mmHg或舒张压≥ 90mmHg,或自我报告的经医师诊断和当前接受治疗的高血压患者。该研究的暴露因素包括研究地点和海拔高度以及可改变的危险因素。研究人员使用广义线性模型来估计高血压发病率、发病率比值(IRR)、95%可信区间、人群归因分数(PAFS)。

该研究收集了3237名参与者的信息,参与者平均年龄为55.8(SD±12.7)岁,48.4%为男性,研究人员对这些参与者进行了分析,发现高血压的总体基线患病率为19.7%(95%可信区间为18.4%-21.1%)。共记录了375例新发高血压病例,共有5266人次每年的随访中,研究人员发现高血压发病率为每100人每年为7.12例(95%可信区间为6.44-7.88)。相比于高度城市化的个体,位于半城市化地区的个体发生高血压的风险更高(IRR为1.76;95%可信区间为1.39-2.23);然而,那些来自于高海拔地区的个体发生高血压的风险较低(IRR为0.74;95%可信区间为0.58-0.95)。肥胖是高血压主要的危险因素并存在很大的变异性,根据研究区域PAF范围从12.5%-42.4%。

这些研究结果表明进展为高血压的异质性主要取决于城市化进程和研究区域的海拔高度。

原始出处:

Antonio Bernabé-Ortiz,et al. Impact of urbanisation and altitude on the incidence of, and risk factors for, hypertension. Heart. 2017. http://heart.bmj.com/content/early/2017/01/23/heartjnl-2016-310347.abstract

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    2017-01-31 卡圣

    长见识了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1688380, encodeId=f65c168838058, content=<a href='/topic/show?id=df81656161b' target=_blank style='color:#2F92EE;'>#海拔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65616, encryptionId=df81656161b, topicName=海拔)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f1c128575901, createdName=12498974m60暂无昵称, createdTime=Thu Feb 09 06:37:00 CST 2017, time=2017-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006220, encodeId=163220062204b, content=<a href='/topic/show?id=39a3415997f' target=_blank style='color:#2F92EE;'>#城市化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41599, encryptionId=39a3415997f, topicName=城市化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Wed Mar 22 06:37:00 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823305, encodeId=d58a1823305d8, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Thu Aug 31 18:37:00 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=173386, encodeId=ffb51e338657, content=长见识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOWcPEsEP4FrvDcicue5V6rMkmXmY73KjYP59vQrEdjU89iaN4ZkOhsItlHkmGTjhV3b5S3zOQA4E0/0, createdBy=cc261682151, createdName=卡圣, createdTime=Tue Jan 31 06:28:36 CST 2017, time=2017-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356164, encodeId=c0ac13561641c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jan 27 09:37:00 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562430, encodeId=1a8815624302f, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Jan 27 09:37:00 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172652, encodeId=afcb1e265222, content=城市化人们的压力也大起来了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Thu Jan 26 09:42:16 CST 2017, time=2017-01-26, status=1, ipAttribution=)]
    2017-01-27 zhaojie88
  6. [GetPortalCommentsPageByObjectIdResponse(id=1688380, encodeId=f65c168838058, content=<a href='/topic/show?id=df81656161b' target=_blank style='color:#2F92EE;'>#海拔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65616, encryptionId=df81656161b, topicName=海拔)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f1c128575901, createdName=12498974m60暂无昵称, createdTime=Thu Feb 09 06:37:00 CST 2017, time=2017-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006220, encodeId=163220062204b, content=<a href='/topic/show?id=39a3415997f' target=_blank style='color:#2F92EE;'>#城市化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41599, encryptionId=39a3415997f, topicName=城市化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Wed Mar 22 06:37:00 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823305, encodeId=d58a1823305d8, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Thu Aug 31 18:37:00 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=173386, encodeId=ffb51e338657, content=长见识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOWcPEsEP4FrvDcicue5V6rMkmXmY73KjYP59vQrEdjU89iaN4ZkOhsItlHkmGTjhV3b5S3zOQA4E0/0, createdBy=cc261682151, createdName=卡圣, createdTime=Tue Jan 31 06:28:36 CST 2017, time=2017-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356164, encodeId=c0ac13561641c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jan 27 09:37:00 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562430, encodeId=1a8815624302f, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Jan 27 09:37:00 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172652, encodeId=afcb1e265222, content=城市化人们的压力也大起来了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Thu Jan 26 09:42:16 CST 2017, time=2017-01-26, status=1, ipAttribution=)]
    2017-01-27 slcumt
  7. [GetPortalCommentsPageByObjectIdResponse(id=1688380, encodeId=f65c168838058, content=<a href='/topic/show?id=df81656161b' target=_blank style='color:#2F92EE;'>#海拔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65616, encryptionId=df81656161b, topicName=海拔)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f1c128575901, createdName=12498974m60暂无昵称, createdTime=Thu Feb 09 06:37:00 CST 2017, time=2017-02-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2006220, encodeId=163220062204b, content=<a href='/topic/show?id=39a3415997f' target=_blank style='color:#2F92EE;'>#城市化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41599, encryptionId=39a3415997f, topicName=城市化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Wed Mar 22 06:37:00 CST 2017, time=2017-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823305, encodeId=d58a1823305d8, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Thu Aug 31 18:37:00 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=173386, encodeId=ffb51e338657, content=长见识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOWcPEsEP4FrvDcicue5V6rMkmXmY73KjYP59vQrEdjU89iaN4ZkOhsItlHkmGTjhV3b5S3zOQA4E0/0, createdBy=cc261682151, createdName=卡圣, createdTime=Tue Jan 31 06:28:36 CST 2017, time=2017-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356164, encodeId=c0ac13561641c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Jan 27 09:37:00 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562430, encodeId=1a8815624302f, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Jan 27 09:37:00 CST 2017, time=2017-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=172652, encodeId=afcb1e265222, content=城市化人们的压力也大起来了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=071c2012037, createdName=wmu姿, createdTime=Thu Jan 26 09:42:16 CST 2017, time=2017-01-26, status=1, ipAttribution=)]
    2017-01-26 wmu姿

    城市化人们的压力也大起来了

    0