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Biomaterials：新型生物载体可有效通过血脑屏障输送药物

2018-09-27 MedSci MedSci原创

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大多数有效的治疗剂在全身给药后不能穿过血脑屏障，需要开发非常规的，临床上适用的药物递送系统。生物活性载体或是解决这一问题的有效手段。 本研究中，研究人员报告了一种新的药物输送方法，利用活细胞作为跨越血脑屏障的药物运输载体。细胞背包，直径为7-10微米，厚度为几百纳米的聚合物贴片，是一种潜在的有趣方法，因为它们可以作为与细胞载体一起输送的药物贮库，而不会被吞噬。装有强效抗氧化剂，过氧化氢酶的背

大多数有效的治疗剂在全身给药后不能穿过血脑屏障，需要开发非常规的，临床上适用的药物递送系统。生物活性载体或是解决这一问题的有效手段。

本研究中，研究人员报告了一种新的药物输送方法，利用活细胞作为跨越血脑屏障的药物运输载体。细胞背包，直径为7-10微米，厚度为几百纳米的聚合物贴片，是一种潜在的有趣方法，因为它们可以作为与细胞载体一起输送的药物贮库，而不会被吞噬。装有强效抗氧化剂，过氧化氢酶的背包附着于自体巨噬细胞并全身给予患有脑炎症的小鼠。使用炎症反应细胞使靶向药物转运到发炎的大脑。此外，装载过氧化氢酶的背包显示出有效的治疗效果，可以使体外活化的小胶质细胞释放的自由基失活。

综上所述，这种用于药物运输和释放的方法可以加速用于神经退行性疾病的新药物制剂的开发。

原始出处：

Natalia L. Klyachko, Roberta Polak, et al., Macrophages with cellular backpacks for targeted drug delivery to the brain. Biomaterials. 2017 Sep; 140: 79–87.

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    2018-12-08 zhangyxzsh

    #Biomaterials#

    0

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    2019-03-31 sunylz

    #Bio#

    0

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    2019-01-24 mei539

    #载体#

    0

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    2018-09-28 zhangying8788

    #血脑屏障#

    0

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    2018-09-27 明月清辉

    谢谢分享，学习了

    0

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    2018-09-27 liumin1987

    新型生物载体，学习了。

    0

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    2018-09-27 txqjm

    谢谢了，学习

    0

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    2018-09-27 惠映实验室

    学习了，谢谢分享。

    0