Chest:阵发性和持续房颤患者无症状表现状态的临床影响!

2017-08-18 xing.T MedSci原创

由此可见,对于PAF患者,无症状的临床状态与年龄较大、男性、具有更高的卒中风险、更多的并发症以及更高的全因死亡率相关,而这些特征和结局在SAF患者中没有观察到。

无症状性阵发性房颤或持续性/永久性房颤临床特征和结局在很大程度上仍是未知的。近日,呼吸领域权威杂志chest上针对这一临床问题发表了一篇研究文章。

日本Fushimi房颤研究是一个以社区为基础的前瞻性房颤患者调查研究。研究人员调查了有症状和无症状的阵发性房颤(n=1837)和持续性/永久性房颤(n=1912)患者的临床特征和结局。

在阵发性房颤(PAF)组,无症状患者年龄较大(无症状 vs. 有症状:74.1 vs. 71.1岁;P<0.01),更多的为男性(62.1% vs. 55.6%;P<0.01),并且有较高的CHA2DS2-VASc评分(平均为3.37±1.73 vs. 2.99±1.63;P<0.01),而持续性房颤的主要合并症以及CHA2DS2-VASc评分与持续性房颤(SAF)组相当。多变量分析显示,年龄(≥75岁)、脑卒中/SE病史、男性、慢性肾脏病是PAF患者无症状状态的独立决定因素,而年龄在SAF组中并不显著。在随访期间,在PAF组,无症状患者全因死亡率显著增高(风险比[HR]为1.71;95%可信区间[CI]为1.31-2.29;P<0.01),与有症状的患者相比,而与SAF组的患者相当。

由此可见,对于PAF患者,无症状的临床状态与年龄较大、男性、具有更高的卒中风险、更多的并发症以及更高的全因死亡率相关,而这些特征和结局在SAF患者中没有观察到。

原始出处:

Masahiro Esato,et al. Clinical Impact of Asymptomatic Presentation Status in Patients with Paroxysmal and Sustained Atrial Fibrillation: The Fushimi AF Registry.chest.2017. http://dx.doi.org/10.1016/j.chest.2017.08.004

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    2018-04-17 Smile2680
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    2017-08-19 1e10c84am36(暂无匿称)

    文章很好,赞赞赞

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1930187, encodeId=3b2d193018e55, content=<a href='/topic/show?id=6d7b22e9883' target=_blank style='color:#2F92EE;'>#临床影响#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22798, encryptionId=6d7b22e9883, topicName=临床影响)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sun Jan 28 16:41:00 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929401, encodeId=5c9419294016d, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Tue Apr 17 04:41:00 CST 2018, time=2018-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2050815, encodeId=c8d32050815fa, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sat Feb 03 12:41:00 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1484975, encodeId=f3c114849e562, content=<a href='/topic/show?id=4bbe5902ed2' target=_blank style='color:#2F92EE;'>#无症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59027, encryptionId=4bbe5902ed2, topicName=无症状)], attachment=null, authenticateStatus=null, createdAvatar=Bioon/avatar/20180429/70baad2aa5a046c5aa2914d262de7d37.jpg, createdBy=bd077990475, createdName=12498da4m34(暂无昵称), createdTime=Sun Aug 20 06:41:00 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614385, encodeId=7f841614385d3, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Aug 20 06:41:00 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234988, encodeId=f675234988e3, content=文章很好,赞赞赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Aug 19 07:54:26 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234976, encodeId=a78e2349e62b, content=很好的文章,认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo61WAV0ROeLAoicPxPKoKaogwLWLL8STv86qplbdOibN2YR4KxkJicqNectCXGR8gPJhGLc7yYLSdnpx4kaVXndTfu/0, createdBy=a6962042337, createdName=1391e9f2a7m, createdTime=Sat Aug 19 07:44:09 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-08-19 1391e9f2a7m

    很好的文章,认真学习

    0