Medicine:年轻缺血性卒中和先前存在精神障碍

2015-09-26 phylis 译 MedSci原创

先前研究表明精神障碍比如:严重抑郁症,双相障碍以及酒精使用障碍与缺血性卒中的发生相关。然而,在精神障碍和年轻患者卒中之间的关系研究的较少。应用台湾国家健康保险数据库,招募了1998年到2011年间,18到45岁缺血性卒中患者,8252名年龄和性别相匹配的对照组。确定先前存在精神障碍的受试者。校正先前存在生理疾病和人口学数据。缺血性卒中的患者先前存在精神障碍的风险较高,包括双相障碍(OR: 2.23

先前的研究表明精神障碍比如:严重抑郁症、双相障碍以及酒精使用障碍与缺血性卒中的发生相关。然而,在精神障碍和年轻患者卒中之间的关系研究的较少。

应用台湾国家健康保险数据库,招募了1998年到2011年间,18到45岁缺血性卒中患者,8252名年龄和性别相匹配的对照组。确定先前存在精神障碍的受试者。校正先前存在生理疾病和人口学数据。

缺血性卒中的患者先前存在精神障碍的风险较高,包括双相障碍(OR: 2.23, 95% CI: 1.06∼4.67),抑郁症(OR: 2.15, 95% CI: 1.62∼2.86),焦虑障碍(OR: 2.63, 95% CI: 1.87∼3.69),酒精使用障碍(OR: 2.86, 95% CI: 1.79∼4.57)。年轻缺血性卒中(年龄大于30岁)与先前存在抑郁症(OR: 1.49, 95% CI: 1.05∼2.11)、焦虑障碍(OR: 1.99, 95% CI: 1.33∼2.97)以及酒精使用障碍(OR: 2.54, 95% CI: 1.55∼4.14)风险相关。


非常年轻的卒中患者(年龄小于30岁)仅与先前存在抑郁症相关(OR: 4.15, 95% CI: 1.47∼11.72)。

校正人口学数据以及卒中相关医疗共发病后,缺血性卒中年龄低于45岁的患者先前存在双相障碍
抑郁症、焦虑障碍以及酒精使用障碍风险较高。

原文出处:

Chiu YC, Bai YM, Su TP, et al. Ischemic Stroke in Young Adults and Preexisting Psychiatric Disorders: A Nationwide Case-Control Study. Medicine (Baltimore).Sep 9, 2015.

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    2016-02-22 jeanqiuqiu
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    2015-10-03 kalseyzl
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