J Endod:对人牙齿使用胶原-羟磷灰石支架牙髓再生疗法的临床、放射线及组织学疗效

2019-02-06 lishiting MedSci原创

牙髓再生疗法(RET)的组织学观察显示,根管区域组织的类型、质量和数量是不可预测的。这篇研究的目的是为了评估使用SynOss Putty (Collagen Matrix Inc, Oakland, NJ)作为支架的RET对人未感染未发育成熟牙齿的临床、放射线及组织学疗效。

牙髓再生疗法(RET)的组织学观察显示,根管区域组织的类型、质量和数量是不可预测的。这篇研究的目的是为了评估使用SynOss Putty (Collagen Matrix Inc, Oakland, NJ)作为支架的RET对人未感染未发育成熟牙齿的临床、放射线及组织学疗效。

研究纳入了3名患者的3对上/下颌计划拔除的第一前磨牙作为试验对象。敏感性测试确定牙髓有活力。在知情同意、麻醉和橡皮障隔离后拔出牙髓。使用以下支架实施RET:在患者1的2颗牙齿中SynOss Putty +血块, 患者2种SynOss Putty加或不加血块, 患者3为SynOss Putty +血块或仅血块。在术后随访平均2.5-7.5个月时,对牙齿进行临床和放射线影像评估,拔除牙齿进行组织学评估。

结果显示,患者在治疗后无任何症状。放射线影像观察显示,治疗后牙根有继续发育的特征。组织学观察显示,施以SynOss Putty +血块的牙齿根管内支架颗粒凝固,周围存在矿化组织,并在牙本质壁上有新形成的牙骨质样结构。施以SynOss Putty未加blood的牙齿显示尖周损伤形成。仅施以血块的牙齿显示,尖周来源的组织长入根管区域。

结论:对未发育成熟未感染的牙齿施以SynOss Putty +血块作为支架的RET可以得到预期的组织形成和矿化模式。新形成的矿化组织和牙骨质固化在牙本质壁上。

原始出处:

Nosrat A, Kolahdouzan A, et al. Clinical, Radiographic, and Histologic Outcome of Regenerative Endodontic Treatment in Human Teeth Using a Novel Collagen-hydroxyapatite Scaffold. J Endod. 2019 Feb;45(2):136-143. doi: 10.1016/j.joen.2018.10.012.

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    2020-01-11 jxrzshh
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    2019-02-08 zhouqu_8
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    2019-02-06 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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