Stroke:缺血性卒中合并精神疾病与低溶栓率有关!

2018-01-27 xing.T MedSci原创

由此可见,急性缺血性脑卒中患者伴发精神疾病的患者接受IVT治疗的几率明显较低。了解这样的患者使用IVT的障碍可能有助于增加获得以证据为基础的卒中护理干预。

静脉溶栓(IVT)改善急性缺血性卒中患者的预后,但未被充分利用的。精神疾病在美国很普遍,患有精神疾病的病人在治疗一系列疾病时都存在与一般人群有差异的现象。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在明确伴发的精神疾病是否与急性缺血性脑卒中患者使用IVT的差异有关。

在全国住院患者中,研究人员确定了2007年至2011年期间诊断的急性缺血性卒中患者。精神疾病是根据国际疾病分类第九版来定义,临床修正代码用于精神分裂症或其他精神疾病、双相情感障碍、抑郁或焦虑的诊断。将人口统计学指标、临床和医院因素进行调整后,研究人员采用Logistic回归评估了IVT和精神疾病之间的相关性。

该研究共纳入了325009例符合标准的缺血性卒中患者,12.8%的患者有明确的精神病合并症。3.6%的精神病合并症患者接受了IVT治疗,4.4%的没有精神疾病患者接受了IVT治疗(P<0.001)。任何精神疾病的存在是与较低的接受IVT治疗几率有关(调整后的比值比为0.80;95%可信区间为0.76-0.85)。当对精神科诊断为精神分裂症或其他精神病、焦虑或抑郁的个体单独进行了分析,其接受IVT治疗的比值明显低于无精神病的个体。

由此可见,急性缺血性脑卒中患者伴发精神疾病的患者接受IVT治疗的几率明显较低。了解这样的患者使用IVT的障碍可能有助于增加获得以证据为基础的卒中护理干预。

原始出处:

Diana M. Bongiorno,et al. Comorbid Psychiatric Disease Is Associated With Lower Rates of Thrombolysis in Ischemic Stroke.Stroke. 2018. https://doi.org/10.1161/STROKEAHA.117.020295

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    2018-01-27 139****5926

    好好文章学习了

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