J Endod:光交联纳米粒显微组织工程根部牙本质改善牙髓治疗牙齿的疲劳强度

2020-03-25 lishiting MedSci原创

采用生物多聚体纳米粒实施的显微组织工程根管牙本质对于改善因医源性导致抗力减弱根部牙本质的机械特质具有一定的潜力。这篇研究的目的是采用光 (photodynamic-activated [PDA])交联

采用生物多聚体纳米粒实施的显微组织工程根管牙本质对于改善因医源性导致抗力减弱根部牙本质的机械特质具有一定的潜力。这篇研究的目的是采用光 (photodynamic-activated [PDA])交联壳聚糖纳米粒(CSnps)实施显微组织工程根部牙本质,并评估其表面机械特质、整体生物力学反应和疲劳强度。

研究将实验共分为3个部分:部分1,根管牙本质切片施以CSnps和化学(1-ethyl-3-[3-dimethylaminopropyl]carbodiimide [EDC]交联CSnps)与光学交联CSnps处理前后置于纳米检测仪进行分析,以评估处理过表面的特质(n = 84 points/group);部分2,施以PDA交联CSnps处理过的根管牙本质切片通过专用的moiré干涉测量法进行应力分析(n = 5/group);部分3,对根管牙本质样本施以EDC交联CSnps, PDA交联CSnps处理以及对照控制,通过加速疲劳负载法进行测试,评估牙本质折断时的持续负载和循环(n = 15/group)。数据采用paired sample t检验, trend analysis和Kaplan-Meier with log-rank检验进行统计学评估,显著性水平设置为.05。

结果显示,采用PDA交联CSnps实施的显微组织工程根部牙本质其弹性模量增加16.8%,并且在颈部牙本质的应力分布显著降低(P < .01)。处理过的根部牙本质在治疗后,根尖区域所形成的拉伸应力显著下降(P < .05)。存留实验结果显示,疲劳强度在不同评估条件下存在显著性差异(P < .05) (ie, PDA cross-linked CSnps > EDC cross-linked CSnps > control)。

结论:这篇研究表明,采用PDA交联CSnps实施的显微组织工程根管牙本质对牙髓治疗牙齿在减少根部应力分布和改善疲劳负载抗力方面具有一定的潜力。

原始出处

Li FC, Nicholson E, et al. Microtissue Engineering Root Dentin with Photodynamically Cross-linked Nanoparticles Improves Fatigue Resistance of Endodontically Treated Teeth. J Endod. 2020 Mar 12. pii: S0099-2399(20)30074-1. doi: 10.1016/j.joen.2020.01.021.

 

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    2020-08-18 jxrzshh
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    2020-03-27 tamgche
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1669843, encodeId=977616698430d, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Tue Aug 18 22:31:47 CST 2020, time=2020-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1772998, encodeId=fc6a1e729983d, content=<a href='/topic/show?id=89f3e742947' target=_blank style='color:#2F92EE;'>#纳米粒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77429, encryptionId=89f3e742947, topicName=纳米粒)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e8ae38449394, createdName=zjubiostat, createdTime=Fri May 08 03:31:47 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1260915, encodeId=334c126091524, content=<a href='/topic/show?id=493ee0559a7' target=_blank style='color:#2F92EE;'>#疲劳#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70559, encryptionId=493ee0559a7, topicName=疲劳)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=674961, createdName=tamgche, createdTime=Fri Mar 27 03:31:47 CST 2020, time=2020-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417214, encodeId=29ce141e214ee, content=<a href='/topic/show?id=8b72e769056' target=_blank style='color:#2F92EE;'>#组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77690, encryptionId=8b72e769056, topicName=组织工程)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c62f3243688, createdName=zhu_jun9838, createdTime=Fri Mar 27 03:31:47 CST 2020, time=2020-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430222, encodeId=a295143022284, content=<a href='/topic/show?id=b58f6e691fc' target=_blank style='color:#2F92EE;'>#牙齿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67691, encryptionId=b58f6e691fc, topicName=牙齿)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Mar 27 03:31:47 CST 2020, time=2020-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441989, encodeId=1ff0144198965, content=<a href='/topic/show?id=67526e55924' target=_blank style='color:#2F92EE;'>#牙本质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67559, encryptionId=67526e55924, topicName=牙本质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37364903098, createdName=ms8538335253054589, createdTime=Fri Mar 27 03:31:47 CST 2020, time=2020-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468084, encodeId=71891468084d2, content=<a href='/topic/show?id=957b6e6754e' target=_blank style='color:#2F92EE;'>#牙髓治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67675, encryptionId=957b6e6754e, topicName=牙髓治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=876d6876924, createdName=hunizi007, createdTime=Fri Mar 27 03:31:47 CST 2020, time=2020-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630314, encodeId=2ba31630314a4, content=<a href='/topic/show?id=bf3de05617b' target=_blank style='color:#2F92EE;'>#疲劳强度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70561, encryptionId=bf3de05617b, topicName=疲劳强度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=015821484104, createdName=budeshao, createdTime=Fri Mar 27 03:31:47 CST 2020, time=2020-03-27, status=1, ipAttribution=)]
    2020-03-27 zhouqu_8
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