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Clinica Chimica Acta：靶向测序检测卵巢癌透明细胞癌中ARID1A和PIK3CA的高频突变

2019-08-08 不详 MedSci原创

靶向测序卵巢癌透明细胞癌
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本研究以台湾地区为研究对象，对用福尔马林固定石蜡包埋<span lang="EN-US" style="font-size:12.0pt;mso-bidi-font-size:14.0pt;font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;; mso-fareast-font-family:宋体;mso-bidi-font-family:

本研究以台湾地区为研究对象，对用福尔马林固定石蜡包埋(FFPE)肿瘤标本中的9个癌相关基因进行靶向测序，以评估上皮性卵巢癌的突变情况。

研究人员通过对16例上皮性卵巢癌患者的32例福尔马林固定石蜡包埋(FFPE)肿瘤标本进行靶向测序。采用深度测序法(>1000×)检测9个癌相关基因的遗传变化。

研究显示，最常见的突变基因是ARID1A和PIK3CA。其中，77.8%的卵巢透明细胞癌患者存在ARID1A突变，66.7%的卵巢透明细胞癌患者存在PIK3CA突变。其它基因突变，包括MLH1(6.3%)和CREBBP(6.3%)均可检测到。此外，还发现肿瘤中同时存在ARID1A-PIK3CA突变(43.8%)和ARID1A-KRAS突变(12.5%)。还应该指出的是，研究人员发现了三种共存突变，即ARID1A-KRAS-PIK3CA突变和ARID1A-CREBBP-PIK3CA突变。

总之，本研究在台湾人群中发现上皮性卵巢癌(EOC)患者的新基因改变。需要进一步研究阐明染色质重构的机制，研究PI3K/AKT通路的作用，确定这些机制在肿瘤发展和卵巢恶性肿瘤进展中的关键作用，进而探索新的靶向治疗方法。

原始出处：

Yu-Fa Su，Eing-Mei Tsai，Targeted sequencing of a specific gene panel detects a high frequency of ARID1A and PIK3CA mutations in ovarian clear cell carcinoma

本文系梅斯医学（MedSci）原创编译整理，转载需授权！


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createdTime=Mon Aug 19 07:23:35 CST 2019, time=2019-08-19, status=1, ipAttribution=)]
    2020-04-08 xinmeili

    #PIK3CA#

    0

  2. 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createdTime=Mon Aug 19 07:23:35 CST 2019, time=2019-08-19, status=1, ipAttribution=)]
    2020-01-01 qingting

    #细胞癌#

    0

  3. 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createdTime=Mon Aug 19 07:23:35 CST 2019, time=2019-08-19, status=1, ipAttribution=)]
    2020-05-31 wmr111

    #透明细胞癌#

    0

  4. 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style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun Dec 15 14:47:00 CST 2019, time=2019-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371733, encodeId=44413e173398, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Sat Aug 24 09:40:57 CST 2019, time=2019-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371622, encodeId=d9433e162290, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Wed Aug 21 21:19:08 CST 2019, time=2019-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371572, encodeId=17523e157274, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Tue Aug 20 23:12:18 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371481, encodeId=202d3e148190, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Mon Aug 19 07:23:35 CST 2019, time=2019-08-19, status=1, ipAttribution=)]
    2020-02-06 chaojitidian

    #ARID1A#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2007520, encodeId=f0d6200e520e1, content=<a href='/topic/show?id=fe2b142e95c' target=_blank style='color:#2F92EE;'>#PIK3CA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14279, encryptionId=fe2b142e95c, topicName=PIK3CA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Wed Apr 08 07:47:00 CST 2020, time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978875, encodeId=b98b19e887567, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Wed Jan 01 07:47:00 CST 2020, time=2020-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2010064, encodeId=526b2010064db, content=<a href='/topic/show?id=6d13948196c' target=_blank style='color:#2F92EE;'>#透明细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94819, encryptionId=6d13948196c, topicName=透明细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f1167, createdName=wmr111, createdTime=Sun May 31 18:47:00 CST 2020, time=2020-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036244, encodeId=4402203624485, content=<a href='/topic/show?id=abd22e5597' target=_blank style='color:#2F92EE;'>#ARID1A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2755, encryptionId=abd22e5597, topicName=ARID1A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Thu Feb 06 14:47:00 CST 2020, time=2020-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2066060, encodeId=78d92066060f0, content=<a href='/topic/show?id=47e99992319' target=_blank style='color:#2F92EE;'>#靶向测序#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99923, encryptionId=47e99992319, topicName=靶向测序)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Apr 06 20:47:00 CST 2020, time=2020-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849692, encodeId=169e1849692ed, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun Dec 15 14:47:00 CST 2019, time=2019-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371733, encodeId=44413e173398, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Sat Aug 24 09:40:57 CST 2019, time=2019-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371622, encodeId=d9433e162290, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Wed Aug 21 21:19:08 CST 2019, time=2019-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371572, encodeId=17523e157274, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Tue Aug 20 23:12:18 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371481, encodeId=202d3e148190, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Mon Aug 19 07:23:35 CST 2019, time=2019-08-19, status=1, ipAttribution=)]
    2020-04-06 膀胱癌

    #靶向测序#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2007520, encodeId=f0d6200e520e1, content=<a href='/topic/show?id=fe2b142e95c' target=_blank style='color:#2F92EE;'>#PIK3CA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14279, encryptionId=fe2b142e95c, topicName=PIK3CA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Wed Apr 08 07:47:00 CST 2020, time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978875, encodeId=b98b19e887567, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Wed Jan 01 07:47:00 CST 2020, time=2020-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2010064, encodeId=526b2010064db, content=<a href='/topic/show?id=6d13948196c' target=_blank style='color:#2F92EE;'>#透明细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94819, encryptionId=6d13948196c, topicName=透明细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f1167, createdName=wmr111, createdTime=Sun May 31 18:47:00 CST 2020, time=2020-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036244, encodeId=4402203624485, content=<a href='/topic/show?id=abd22e5597' target=_blank style='color:#2F92EE;'>#ARID1A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2755, encryptionId=abd22e5597, topicName=ARID1A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Thu Feb 06 14:47:00 CST 2020, time=2020-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2066060, encodeId=78d92066060f0, content=<a href='/topic/show?id=47e99992319' target=_blank style='color:#2F92EE;'>#靶向测序#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99923, encryptionId=47e99992319, topicName=靶向测序)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Apr 06 20:47:00 CST 2020, time=2020-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849692, encodeId=169e1849692ed, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun Dec 15 14:47:00 CST 2019, time=2019-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371733, encodeId=44413e173398, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Sat Aug 24 09:40:57 CST 2019, time=2019-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371622, encodeId=d9433e162290, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Wed Aug 21 21:19:08 CST 2019, time=2019-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371572, encodeId=17523e157274, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Tue Aug 20 23:12:18 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371481, encodeId=202d3e148190, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Mon Aug 19 07:23:35 CST 2019, time=2019-08-19, status=1, ipAttribution=)]
    2019-12-15 windight

    #CTA#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2007520, encodeId=f0d6200e520e1, content=<a href='/topic/show?id=fe2b142e95c' target=_blank style='color:#2F92EE;'>#PIK3CA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14279, encryptionId=fe2b142e95c, topicName=PIK3CA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Wed Apr 08 07:47:00 CST 2020, time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978875, encodeId=b98b19e887567, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Wed Jan 01 07:47:00 CST 2020, time=2020-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2010064, encodeId=526b2010064db, content=<a href='/topic/show?id=6d13948196c' target=_blank style='color:#2F92EE;'>#透明细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94819, encryptionId=6d13948196c, topicName=透明细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f1167, createdName=wmr111, createdTime=Sun May 31 18:47:00 CST 2020, time=2020-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036244, encodeId=4402203624485, content=<a href='/topic/show?id=abd22e5597' target=_blank style='color:#2F92EE;'>#ARID1A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2755, encryptionId=abd22e5597, topicName=ARID1A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Thu Feb 06 14:47:00 CST 2020, time=2020-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2066060, encodeId=78d92066060f0, content=<a href='/topic/show?id=47e99992319' target=_blank style='color:#2F92EE;'>#靶向测序#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99923, encryptionId=47e99992319, topicName=靶向测序)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Apr 06 20:47:00 CST 2020, time=2020-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849692, encodeId=169e1849692ed, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun Dec 15 14:47:00 CST 2019, time=2019-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371733, encodeId=44413e173398, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Sat Aug 24 09:40:57 CST 2019, time=2019-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371622, encodeId=d9433e162290, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Wed Aug 21 21:19:08 CST 2019, time=2019-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371572, encodeId=17523e157274, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Tue Aug 20 23:12:18 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371481, encodeId=202d3e148190, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Mon Aug 19 07:23:35 CST 2019, time=2019-08-19, status=1, ipAttribution=)]
    2019-08-24 东风不解愁

    很不错的文章分享

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2007520, encodeId=f0d6200e520e1, content=<a href='/topic/show?id=fe2b142e95c' target=_blank style='color:#2F92EE;'>#PIK3CA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14279, encryptionId=fe2b142e95c, topicName=PIK3CA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Wed Apr 08 07:47:00 CST 2020, time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978875, encodeId=b98b19e887567, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Wed Jan 01 07:47:00 CST 2020, time=2020-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2010064, encodeId=526b2010064db, content=<a href='/topic/show?id=6d13948196c' target=_blank style='color:#2F92EE;'>#透明细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94819, encryptionId=6d13948196c, topicName=透明细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f1167, createdName=wmr111, createdTime=Sun May 31 18:47:00 CST 2020, time=2020-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036244, encodeId=4402203624485, content=<a href='/topic/show?id=abd22e5597' target=_blank style='color:#2F92EE;'>#ARID1A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2755, encryptionId=abd22e5597, topicName=ARID1A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Thu Feb 06 14:47:00 CST 2020, time=2020-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2066060, encodeId=78d92066060f0, content=<a href='/topic/show?id=47e99992319' target=_blank style='color:#2F92EE;'>#靶向测序#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99923, encryptionId=47e99992319, topicName=靶向测序)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Apr 06 20:47:00 CST 2020, time=2020-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849692, encodeId=169e1849692ed, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun Dec 15 14:47:00 CST 2019, time=2019-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371733, encodeId=44413e173398, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Sat Aug 24 09:40:57 CST 2019, time=2019-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371622, encodeId=d9433e162290, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Wed Aug 21 21:19:08 CST 2019, time=2019-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371572, encodeId=17523e157274, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Tue Aug 20 23:12:18 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371481, encodeId=202d3e148190, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Mon Aug 19 07:23:35 CST 2019, time=2019-08-19, status=1, ipAttribution=)]
    2019-08-21 东风不解愁

    很不错的文章分享

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2007520, encodeId=f0d6200e520e1, content=<a href='/topic/show?id=fe2b142e95c' target=_blank style='color:#2F92EE;'>#PIK3CA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14279, encryptionId=fe2b142e95c, topicName=PIK3CA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Wed Apr 08 07:47:00 CST 2020, time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978875, encodeId=b98b19e887567, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Wed Jan 01 07:47:00 CST 2020, time=2020-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2010064, encodeId=526b2010064db, content=<a href='/topic/show?id=6d13948196c' target=_blank style='color:#2F92EE;'>#透明细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94819, encryptionId=6d13948196c, topicName=透明细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f1167, createdName=wmr111, createdTime=Sun May 31 18:47:00 CST 2020, time=2020-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036244, encodeId=4402203624485, content=<a href='/topic/show?id=abd22e5597' target=_blank style='color:#2F92EE;'>#ARID1A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2755, encryptionId=abd22e5597, topicName=ARID1A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Thu Feb 06 14:47:00 CST 2020, time=2020-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2066060, encodeId=78d92066060f0, content=<a href='/topic/show?id=47e99992319' target=_blank style='color:#2F92EE;'>#靶向测序#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99923, encryptionId=47e99992319, topicName=靶向测序)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Apr 06 20:47:00 CST 2020, time=2020-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849692, encodeId=169e1849692ed, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun Dec 15 14:47:00 CST 2019, time=2019-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371733, encodeId=44413e173398, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Sat Aug 24 09:40:57 CST 2019, time=2019-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371622, encodeId=d9433e162290, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Wed Aug 21 21:19:08 CST 2019, time=2019-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371572, encodeId=17523e157274, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Tue Aug 20 23:12:18 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371481, encodeId=202d3e148190, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Mon Aug 19 07:23:35 CST 2019, time=2019-08-19, status=1, ipAttribution=)]
    2019-08-20 东风不解愁

    很不错的文章分享

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=2007520, encodeId=f0d6200e520e1, content=<a href='/topic/show?id=fe2b142e95c' target=_blank style='color:#2F92EE;'>#PIK3CA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14279, encryptionId=fe2b142e95c, topicName=PIK3CA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Wed Apr 08 07:47:00 CST 2020, time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1978875, encodeId=b98b19e887567, content=<a href='/topic/show?id=3b90e79787f' target=_blank style='color:#2F92EE;'>#细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77978, encryptionId=3b90e79787f, topicName=细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e457184, createdName=qingting, createdTime=Wed Jan 01 07:47:00 CST 2020, time=2020-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2010064, encodeId=526b2010064db, content=<a href='/topic/show?id=6d13948196c' target=_blank style='color:#2F92EE;'>#透明细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94819, encryptionId=6d13948196c, topicName=透明细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f1167, createdName=wmr111, createdTime=Sun May 31 18:47:00 CST 2020, time=2020-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2036244, encodeId=4402203624485, content=<a href='/topic/show?id=abd22e5597' target=_blank style='color:#2F92EE;'>#ARID1A#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2755, encryptionId=abd22e5597, topicName=ARID1A)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=295c372, createdName=chaojitidian, createdTime=Thu Feb 06 14:47:00 CST 2020, time=2020-02-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2066060, encodeId=78d92066060f0, content=<a href='/topic/show?id=47e99992319' target=_blank style='color:#2F92EE;'>#靶向测序#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99923, encryptionId=47e99992319, topicName=靶向测序)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Apr 06 20:47:00 CST 2020, time=2020-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1849692, encodeId=169e1849692ed, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Sun Dec 15 14:47:00 CST 2019, time=2019-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371733, encodeId=44413e173398, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Sat Aug 24 09:40:57 CST 2019, time=2019-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371622, encodeId=d9433e162290, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Wed Aug 21 21:19:08 CST 2019, time=2019-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371572, encodeId=17523e157274, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Tue Aug 20 23:12:18 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371481, encodeId=202d3e148190, content=很不错的文章分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b2602128469, createdName=东风不解愁, createdTime=Mon Aug 19 07:23:35 CST 2019, time=2019-08-19, status=1, ipAttribution=)]
    2019-08-19 东风不解愁

    很不错的文章分享

    0

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