Heart:充血的血管阻力预测心肌梗死后的临床结局和微血管损伤!

2017-07-01 xing.T MedSci原创

由此可见,AMI后急诊经皮冠状动脉介入治疗HMR即时测量的临界值为3 mmHg-1•s ,可以识别MVI患者中那些不良临床结果高风险的个体。为此,HMR优于CFR。

急性心肌梗死(AMI)后微血管功能障碍的早期发现可鉴别临床预后不良的高危患者,这些患者可能受益于辅助治疗。近日,在心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员旨在比较侵入性测定的冠脉血流储备(CFR)和充血的微血管阻力(HMR)在预测长期临床结局以及心脏磁共振(CMR)定义的微血管损伤(MVI)的效能。

研究人员在AMI后血运重建获得参与者的同步冠状动脉内多普勒血流速度和压力测量值,并将五个中心的数据进行合并。完成了临床随访的176例患者(平均年龄60±10岁;140例(80%)为男性;130例(74%)ST段抬高的心肌梗死(STEMI)患者和46例(26%)非ST段抬高心肌梗死患者,中位随访时间为3.2年。在110例STEMI患者中,研究人员进行了额外的CMR。

17例(10%)患者发生了死亡和因心衰入院的复合终点。研究人员发现预测复合终点的最佳临界值来CFR为1.5,对于HMR为3mmHg-1•s。CFR<1.5预测的复合终点(风险比为3.5;95%可信区间为1.1至10.8),而不是它的各个组成成分。HMR≥3 mmHg-1•s预测复合终点(风险比为7;95%可信区间为1.5至33.7),其个别组分也一样。HMR在预测MVI的ROC曲线下面积为比CFR要大。HMR仍是不良临床预后和MVI的独立预测因子,而CFR不是。

由此可见,AMI后急诊经皮冠状动脉介入治疗HMR即时测量的临界值为3 mmHg-1•s ,可以识别MVI患者中那些不良临床结果高风险的个体。为此,HMR优于CFR。

原始出处:

Guus A de Waard,et al. Hyperaemic microvascular resistance predicts clinical outcome and microvascular injury after myocardial infarction. Heart. 2017. http://dx.doi.org/10.1136/heartjnl-2017-311431

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    2017-07-03 zhaojie88
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content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Jul 03 05:02:00 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217650, encodeId=11d221e6505d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfDEeydJz0GlP8O0ngrUX6AYCXFic0XDOOAyeQicIqnOd4TrWSwiagJrsFNYuWC1Uc6iavbS1hWt9xtZAhAqLGHqZyl/0, createdBy=42891977006, createdName=1e17414fm02(暂无匿称), createdTime=Sun Jul 02 06:10:27 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217464, encodeId=e59721e46478, content=学习学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7SEMbIqicph9XjjB508YwgovWXrJrvXs6oQCG2x4iaUOS1ouvNLf8dRtkwfFsMN1sRUP5e5rbr7eUJPS8Gdt0aOq/0, createdBy=99cf2073595, createdName=蒋宇, createdTime=Sat Jul 01 19:00:46 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217453, encodeId=988321e45398, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Jul 01 16:48:24 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217436, encodeId=4f5f21e43624, content=不错的文章,值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sat Jul 01 14:47:35 CST 2017, time=2017-07-01, status=1, ipAttribution=)]
    2017-07-03 mgqwxj
  5. 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content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Jul 03 05:02:00 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217650, encodeId=11d221e6505d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfDEeydJz0GlP8O0ngrUX6AYCXFic0XDOOAyeQicIqnOd4TrWSwiagJrsFNYuWC1Uc6iavbS1hWt9xtZAhAqLGHqZyl/0, createdBy=42891977006, createdName=1e17414fm02(暂无匿称), createdTime=Sun Jul 02 06:10:27 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217464, encodeId=e59721e46478, content=学习学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7SEMbIqicph9XjjB508YwgovWXrJrvXs6oQCG2x4iaUOS1ouvNLf8dRtkwfFsMN1sRUP5e5rbr7eUJPS8Gdt0aOq/0, createdBy=99cf2073595, createdName=蒋宇, createdTime=Sat Jul 01 19:00:46 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217453, encodeId=988321e45398, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Jul 01 16:48:24 CST 2017, time=2017-07-01, status=1, 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  6. 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content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Jul 03 05:02:00 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217650, encodeId=11d221e6505d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfDEeydJz0GlP8O0ngrUX6AYCXFic0XDOOAyeQicIqnOd4TrWSwiagJrsFNYuWC1Uc6iavbS1hWt9xtZAhAqLGHqZyl/0, createdBy=42891977006, createdName=1e17414fm02(暂无匿称), createdTime=Sun Jul 02 06:10:27 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217464, encodeId=e59721e46478, content=学习学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7SEMbIqicph9XjjB508YwgovWXrJrvXs6oQCG2x4iaUOS1ouvNLf8dRtkwfFsMN1sRUP5e5rbr7eUJPS8Gdt0aOq/0, createdBy=99cf2073595, createdName=蒋宇, createdTime=Sat Jul 01 19:00:46 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217453, encodeId=988321e45398, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Jul 01 16:48:24 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217436, encodeId=4f5f21e43624, content=不错的文章,值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sat Jul 01 14:47:35 CST 2017, time=2017-07-01, status=1, ipAttribution=)]
    2017-07-03 slcumt
  7. 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content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Jul 03 05:02:00 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217650, encodeId=11d221e6505d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfDEeydJz0GlP8O0ngrUX6AYCXFic0XDOOAyeQicIqnOd4TrWSwiagJrsFNYuWC1Uc6iavbS1hWt9xtZAhAqLGHqZyl/0, createdBy=42891977006, createdName=1e17414fm02(暂无匿称), createdTime=Sun Jul 02 06:10:27 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217464, encodeId=e59721e46478, content=学习学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7SEMbIqicph9XjjB508YwgovWXrJrvXs6oQCG2x4iaUOS1ouvNLf8dRtkwfFsMN1sRUP5e5rbr7eUJPS8Gdt0aOq/0, createdBy=99cf2073595, createdName=蒋宇, createdTime=Sat Jul 01 19:00:46 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217453, encodeId=988321e45398, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Jul 01 16:48:24 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217436, encodeId=4f5f21e43624, content=不错的文章,值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sat Jul 01 14:47:35 CST 2017, time=2017-07-01, status=1, ipAttribution=)]
    2017-07-02 1e17414fm02(暂无匿称)

    学习

    0

  8. 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content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Jul 03 05:02:00 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217650, encodeId=11d221e6505d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfDEeydJz0GlP8O0ngrUX6AYCXFic0XDOOAyeQicIqnOd4TrWSwiagJrsFNYuWC1Uc6iavbS1hWt9xtZAhAqLGHqZyl/0, createdBy=42891977006, createdName=1e17414fm02(暂无匿称), createdTime=Sun Jul 02 06:10:27 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217464, encodeId=e59721e46478, content=学习学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7SEMbIqicph9XjjB508YwgovWXrJrvXs6oQCG2x4iaUOS1ouvNLf8dRtkwfFsMN1sRUP5e5rbr7eUJPS8Gdt0aOq/0, createdBy=99cf2073595, createdName=蒋宇, createdTime=Sat Jul 01 19:00:46 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217453, encodeId=988321e45398, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Jul 01 16:48:24 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217436, encodeId=4f5f21e43624, content=不错的文章,值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sat Jul 01 14:47:35 CST 2017, time=2017-07-01, status=1, ipAttribution=)]
    2017-07-01 蒋宇

    学习学了

    0

  9. 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content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Jul 03 05:02:00 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217650, encodeId=11d221e6505d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfDEeydJz0GlP8O0ngrUX6AYCXFic0XDOOAyeQicIqnOd4TrWSwiagJrsFNYuWC1Uc6iavbS1hWt9xtZAhAqLGHqZyl/0, createdBy=42891977006, createdName=1e17414fm02(暂无匿称), createdTime=Sun Jul 02 06:10:27 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217464, encodeId=e59721e46478, content=学习学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7SEMbIqicph9XjjB508YwgovWXrJrvXs6oQCG2x4iaUOS1ouvNLf8dRtkwfFsMN1sRUP5e5rbr7eUJPS8Gdt0aOq/0, createdBy=99cf2073595, createdName=蒋宇, createdTime=Sat Jul 01 19:00:46 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217453, encodeId=988321e45398, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Jul 01 16:48:24 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217436, encodeId=4f5f21e43624, content=不错的文章,值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sat Jul 01 14:47:35 CST 2017, time=2017-07-01, status=1, ipAttribution=)]
    2017-07-01 1e0f8808m18(暂无匿称)

    学习了,谢谢分享。

    0

  10. 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content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Jul 03 05:02:00 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217650, encodeId=11d221e6505d, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfDEeydJz0GlP8O0ngrUX6AYCXFic0XDOOAyeQicIqnOd4TrWSwiagJrsFNYuWC1Uc6iavbS1hWt9xtZAhAqLGHqZyl/0, createdBy=42891977006, createdName=1e17414fm02(暂无匿称), createdTime=Sun Jul 02 06:10:27 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217464, encodeId=e59721e46478, content=学习学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7SEMbIqicph9XjjB508YwgovWXrJrvXs6oQCG2x4iaUOS1ouvNLf8dRtkwfFsMN1sRUP5e5rbr7eUJPS8Gdt0aOq/0, createdBy=99cf2073595, createdName=蒋宇, createdTime=Sat Jul 01 19:00:46 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217453, encodeId=988321e45398, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Jul 01 16:48:24 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217436, encodeId=4f5f21e43624, content=不错的文章,值得一读, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sat Jul 01 14:47:35 CST 2017, time=2017-07-01, status=1, ipAttribution=)]
    2017-07-01 1e1b8538m79(暂无匿称)

    不错的文章,值得一读

    0

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