Environmental Health Perspectives :空气污染与肺癌死亡率有关

2017-11-01 MedSci MedSci原创

由于空气污染与肺癌有关,人们将其归类为致癌物,但几乎没有证据表明它与身体其他部位的癌症有关联。在巴塞罗那全球健康研究所(ISGlobal)领导的一项新的大规模前瞻性研究中,研究人员观察到某些空气污染物与肾脏、膀胱和结直肠癌的死亡率之间存在关联。这项研究发表在《Environmental Health Perspectives》杂志上,其中包括美国参与癌症预防研究II的60多万名成年人,且从1982


由于空气污染与肺癌有关,人们将其归类为致癌物,但几乎没有证据表明它与身体其他部位的癌症有关联。在巴塞罗那全球健康研究所(ISGlobal)领导的一项新的大规模前瞻性研究中,研究人员观察到某些空气污染物与肾脏、膀胱和结直肠癌的死亡率之间存在关联。

这项研究发表在《Environmental Health Perspectives》杂志上,其中包括美国参与癌症预防研究II的60多万名成年人,且从1982年到2004年随访了22年。研究人员检查了29个长期暴露于与癌症死亡率相关的3种环境污染物的地方--PM2、5、二氧化氮(NO2)和臭氧(O3)。

受试者中有43,000多例非肺癌死亡病例。 PM2.5与肾癌和膀胱癌的死亡率相关,分别增加14%和13%,在暴露的环境中增加4.4μg/ m3。反过来,暴露于NO2与结直肠癌死亡率有关,每增加6.5 ppb增加6%。与其他部位的癌症无显着关联。

该研究的第一作者、ISGlobal研究员米歇尔·特纳(Michelle Turner)说:"尽管许多研究将肺癌与空气污染联系在一起,但在其他部位的癌症,仍然没有证据表明它们与空气污染有关。这项研究表明,空气污染与大多数非肺癌患者的死亡无关,但与肾脏、膀胱癌和结直肠癌的相关性值得进一步研究。"

原文出处: Michelle C. Turner et al, Ambient Air Pollution and Cancer Mortality in the Cancer Prevention Study II, Environmental Health Perspectives (2017).

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    2018-02-17 anminleiryan
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    2017-11-23 lixiaol
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encryptionId=19b88223132, topicName=肺癌死亡率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Fri Feb 16 04:06:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259485, encodeId=169425948550, content=学习了啊......, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/25/50686bfef7f9754dfa5d0ccec059c9de.jpg, createdBy=8d992083353, createdName=139****9672, createdTime=Tue Nov 07 16:37:30 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472575, encodeId=9ac114e257545, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, 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  5. 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createdName=feather89, createdTime=Tue Mar 06 21:06:00 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951994, encodeId=78571951994f9, content=<a href='/topic/show?id=04fa11552da' target=_blank style='color:#2F92EE;'>#Mental#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11552, encryptionId=04fa11552da, topicName=Mental)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Thu Nov 23 21:06:00 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785726, encodeId=ee661e8572620, content=<a href='/topic/show?id=3cf3682845' target=_blank style='color:#2F92EE;'>#Environmental#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6828, 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encryptionId=19b88223132, topicName=肺癌死亡率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Fri Feb 16 04:06:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259485, encodeId=169425948550, content=学习了啊......, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/25/50686bfef7f9754dfa5d0ccec059c9de.jpg, createdBy=8d992083353, createdName=139****9672, createdTime=Tue Nov 07 16:37:30 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472575, encodeId=9ac114e257545, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Fri Nov 03 11:06:00 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524249, encodeId=887f152424950, content=<a href='/topic/show?id=053710045ad' target=_blank style='color:#2F92EE;'>#iron#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10045, encryptionId=053710045ad, topicName=iron)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f1b11597510, createdName=july_979, createdTime=Fri Nov 03 11:06:00 CST 2017, time=2017-11-03, status=1, ipAttribution=)]
  6. 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encryptionId=3cf3682845, topicName=Environmental)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Wed Apr 18 20:06:00 CST 2018, time=2018-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785696, encodeId=6f1e1e8569615, content=<a href='/topic/show?id=9855682e90' target=_blank style='color:#2F92EE;'>#environment#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6827, encryptionId=9855682e90, topicName=environment)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/xkicoVBAnV4HxvdCqC1viaW8wdLQdN9hVP9icgqqDsxC6UVPjfhogdfc2iaU1xNUMVlFl5QicicWrjWQBTsVye5ngOQQ/132, createdBy=f92f2500185, 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encryptionId=19b88223132, topicName=肺癌死亡率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Fri Feb 16 04:06:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259485, encodeId=169425948550, content=学习了啊......, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/25/50686bfef7f9754dfa5d0ccec059c9de.jpg, createdBy=8d992083353, createdName=139****9672, createdTime=Tue Nov 07 16:37:30 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472575, encodeId=9ac114e257545, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Fri Nov 03 11:06:00 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524249, encodeId=887f152424950, content=<a href='/topic/show?id=053710045ad' target=_blank style='color:#2F92EE;'>#iron#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10045, encryptionId=053710045ad, topicName=iron)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f1b11597510, createdName=july_979, createdTime=Fri Nov 03 11:06:00 CST 2017, time=2017-11-03, status=1, ipAttribution=)]
    2018-09-03 shizhenshan
  7. 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  8. 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encryptionId=19b88223132, topicName=肺癌死亡率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Fri Feb 16 04:06:00 CST 2018, time=2018-02-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259485, encodeId=169425948550, content=学习了啊......, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/25/50686bfef7f9754dfa5d0ccec059c9de.jpg, createdBy=8d992083353, createdName=139****9672, createdTime=Tue Nov 07 16:37:30 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472575, encodeId=9ac114e257545, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, 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    2017-11-07 139****9672

    学习了啊......

    0

  9. 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  10. 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    2017-11-03 july_979

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由此可见,这项研究表明短期暴露于PM10、NO2和SO2与增加儿童下呼吸道疾病的数量相关。

Am J Resp Crit Care:儿童尿环境碳负荷:反映居住环境空气污染暴露的新标志物!

由此可见,尿黑碳水平反映了中度并且慢性暴露于与燃烧有关的累积空气污染。这种特殊的生物标志物反映了体内循环的黑碳颗粒,从血液循环到尿液,为解开与颗粒相关的健康效应的复杂性提供了方便。

New Engl J of Med :空气污染与过早死亡的关系!

美国6000多万美国人的新研究 - 约97%的65岁及以上的人 - 表明长期接触空气中的细颗粒物质(PM2.5)和臭氧会增加过早死亡的风险,即使曝光水平低于美国环境保护署目前建立的“国家环境空气质量标准”(NAAQS)。

EUR HEART J :长期暴露在道路交通噪音、环境空气污染竟然与心血管疾病风险有关联!

近日,在医学权威杂志EUR HEART J上面发表了一篇研究文章,研究人员通过血液生物化学评估道路交通噪音、空气污染和心血管疾病风险之间的关联。

FASEB J:空气污染破坏DNA,或致心脏衰竭

暴露在空气污染的环境中,即使对于仍然处在子宫中的胎儿,也可能会带来可怕的风险。一篇新论文解释了为什么会出现这种情况,并描述了空气污染使胎儿在后天容易罹患心脏衰竭的化学过程。

Circulation:中国城市空气污染控制的潜在心血管和死亡率获益

不同程度的空气质量改善会产生241,000生命年甚至更多的健康获益。