SCI REP:血浆C-反应蛋白水平与结直肠腺瘤患病率的相关性分析!

2017-06-30 xing.T MedSci原创

总之,这项研究的结果表明肥胖相关的全身性低度炎症可能在大肠癌发生的早期阶段起着重要的作用。

流行病学研究发现肥胖与结直肠肿瘤之间存在正相关性。肥胖可引起全身性低度炎症,通常用敏感的生物标志物C反应蛋白(CRP)来进行评估。为了解肥胖患者结直肠肿瘤发病原因的分子机制,近日,Scientific reports 杂志上发表了一篇研究文章,该研究对782例腺瘤患者和738例接受全结肠镜检查的患者进行了分析,并对其血浆中CRP水平与结直肠腺瘤患病率进行了评估。

研究人员采用logistic回归模型计算了根据血浆CRP四分位数的腺瘤比值比和95%可信区间。血浆CRP水平与所有受试者较高的腺瘤患病率呈正相关(最高与最低四分位数患者的比值比为1.30;95%可信区间为0.94-1.79;趋势P=0.031)。对腺瘤的大小和数量进行进一步分析显示了腺瘤大小(≥5mm)和多个数量(≥2)呈正相关。对所有受试者的体重指数进一步调整后,这些正相关性减弱至无统计学意义,并且最高与最低血浆CRP四分位数的比值比为1.12(95%可信区间为0.80-1.56;P=0.25)。

总之,这项研究的结果表明肥胖相关的全身性低度炎症可能在大肠癌发生的早期阶段起着重要的作用。

原始出处:

Nano Kigawa,et al. Association of plasma C-reactive protein level with the prevalence of colorectal adenoma: the Colorectal Adenoma Study in Tokyo.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-04780-9

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    2018-05-17 1871cee12fm

    感谢分享

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  5. 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  6. 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  7. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Jul 01 14:29:04 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217214, encodeId=3d8121e214a7, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Fri Jun 30 23:03:32 CST 2017, time=2017-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217185, encodeId=513a21e185ca, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Fri Jun 30 21:27:49 CST 2017, time=2017-06-30, status=1, ipAttribution=)]
    2017-07-02 明天会更好!

    感谢分享!继续关注!

    0

  8. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3886, encryptionId=b265388684, topicName=C-反应蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab8416056084, createdName=szhvet, createdTime=Sun Jul 02 10:35:00 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217699, encodeId=ff1521e69909, content=感谢分享!继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sun Jul 02 08:13:30 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217425, encodeId=c76921e4254d, content=认真学习,不断进步,把经验分享给同好。点赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sat Jul 01 14:29:04 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217214, encodeId=3d8121e214a7, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Fri Jun 30 23:03:32 CST 2017, time=2017-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217185, encodeId=513a21e185ca, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Fri Jun 30 21:27:49 CST 2017, time=2017-06-30, status=1, ipAttribution=)]
    2017-07-01 ylzr123

    认真学习,不断进步,把经验分享给同好。点赞了!

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=315869, encodeId=9f583158691f, content=感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ycT7JPEGDulWj3PHTGDse1gNLsRVWESX6FR1Eacuoba9KQvSLDUuDqzyTRT9PHFibicVpMDria7XDduOLibicSY9Cfic/0, createdBy=723c1919058, createdName=1871cee12fm, createdTime=Thu May 17 06:53:35 CST 2018, time=2018-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837285, encodeId=5fdf183e28549, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3886, encryptionId=b265388684, topicName=C-反应蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab8416056084, createdName=szhvet, createdTime=Sun Jul 02 10:35:00 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217699, encodeId=ff1521e69909, content=感谢分享!继续关注!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Sun Jul 02 08:13:30 CST 2017, time=2017-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217425, encodeId=c76921e4254d, content=认真学习,不断进步,把经验分享给同好。点赞了!, 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channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Fri Jun 30 21:27:49 CST 2017, time=2017-06-30, status=1, ipAttribution=)]
    2017-06-30 luominglian113

    学习了,谢谢分享

    0

  10. 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channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Fri Jun 30 21:27:49 CST 2017, time=2017-06-30, status=1, ipAttribution=)]
    2017-06-30 清风拂面

    谢谢分享学习了

    0

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