Stroke:家族史对年轻卒中患者的影响

2015-06-03 崔倩 译 MedSci原创

背景:脑卒中家族史是脑卒中的一个危险因素。该研究目的是评估脑卒中家族史是否有一定的脑卒中的亚型以及在中青年脑卒中患者中会因性别而不同。    方法:该研究的数据来自于脑卒中患者的法布里研究,一个大型的前瞻性,以医院为基础,在年轻中风患者(年龄<55岁)筛选法布里病的研究,在这项研究中,中风患者的心血管危险因素和中风家族史得到细致的考察并进行分型。  &

背景:卒中家族史是脑卒中的一个危险因素。该研究目的是评估脑卒中家族史是否有一定的脑卒中的亚型以及在中青年脑卒中患者中会因性别而不同。
    
方法:该研究的数据来自于脑卒中患者的法布里研究,一个大型的前瞻性,以医院为基础,在年轻中风患者(年龄<55岁)筛选法布里病的研究,在这项研究中,中风患者的心血管危险因素和中风家族史得到细致的考察并进行分型。
    
结果:中风家族史在4232例短暂性脑缺血发作和缺血性卒中患者的1578例(37.3%)中体现。与父系血统相比,女性患者往往有更多的母系血统的中风史(P=0.027)。根据急性卒中治疗的Org 10172试验,并没有与卒中亚型以及脑白质病变的脑成像有关的现象。患者的解剖报告较少有中风家族史(30.4% vs 36.3%,P=0.018)。有父母脑卒中史的患者的兄弟姐妹卒中现象更常见(3.6% vs 2.6%,P=0.047)。
    
结论:虽然目前大约三分之一的脑卒中家族史患者,没有具体涉及到年轻脑卒中患者的中风的致病亚型。但母系血统中年轻女性中风更常见。

原始出处:

Vincent Thijs, MD, PhD, Ulrike Grittner, PhD, Martin Dichgans, MD, Christian Enzinger, MD, Franz Fazekas, MD, Anne-Katrin Giese, MD, Christof Kessler, MD, Edwin Kolodny, MD, Peter Kropp, PhD, Peter Martus, PhD, Bo Norrving, MD, Erich Bernd Ringelstein, MD, Peter M. Rothwell, FMedSci, Reinhold Schmidt, MD, Christian Tanislav, MD, Turgut Tatlisumak, MD, PhD, Bettina von Sarnowski, MD, Arndt Rolfs, MD, on behalf of the Stroke in Fabry Investigators*,Family History in Young Patients With Stroke.Stroke,2015.6.2

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    2015-06-04 kuibaoli

    看来遗传和许多病相关

    0

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    2015-06-03 1dd7eb8am26(暂无匿称)

    这是和性别有关啊

    0

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    2015-06-03 s312486

    是不是和饮食习惯有关系?

    0

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