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J Hypertens：正常脑血管搏动随年龄的变化及其对微血管病变的影响!

2017-07-11 xing.T MedSci原创

正常脑血管搏动年龄微血管病变
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由此可见，老年患者脑微血管损伤是由于高脉动压力撕裂脆弱介质，造成出血，高脉搏波动流去除内皮细胞，导致血栓形成和微梗死。老年患者的脉搏波动是由下半身早期反射波所引起的。减少或延缓波反射是治疗老年人主动脉硬化的一种合乎逻辑的策略。

老年人的脑部综合征，年轻人创伤后继发性卒中和儿童镰状细胞贫血，与不明原因的微血管损伤和高颅内压或血流波动联系在一起。近日，高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章，该研究的目的是描述流入大脑的年龄相关压力和流量波形，以解释这些在生理功能紊乱，并考虑其临床意义。

研究人员采用经颅多普勒测定了1020例显然是正常的患者（497名男性，21-78岁），大脑中四处脑血管的血流速度波形。研究人员采用SphygmoCor桡动脉压平眼压计获得中央压力波形。在时间和频率域中描述了这种相关性。

研究人员发现进入大脑的血流波形与中心动脉压力波形相似，并且随着年龄有相似的变化。在男性和女性中血流和压力指数与不同年龄呈高度相关（r＝0.58，P＜0.01）。计算出的脑血管阻抗在性别和不同年龄上都是相似的。这种血管床受到心脏直接产生的压力和流量波动的影响，并受到来自下肢身体的强烈反射波的推动。

由此可见，老年患者脑微血管损伤是由于高脉动压力撕裂脆弱介质，造成出血，高脉搏波动流去除内皮细胞，导致血栓形成和微梗死。老年患者的脉搏波动是由下半身早期反射波所引起的。减少或延缓波反射是治疗老年人主动脉硬化的一种合乎逻辑的策略。

原始出处：

Kim, Mi O,et al. Normal cerebral vascular pulsations in humans: changes with age and implications for microvascular disease.Journal of Hypertension. 2017. http://journals.lww.com/jhypertension/Abstract/publishahead/Normal_cerebral_vascular_pulsations_in_humans__.97675.aspx

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    2018-01-05 Luyuxie_17

    #血管病#

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    2018-04-25 feather89

    #PE#

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    2018-03-23 12498ebem19暂无昵称

    #TENS#

    0

  4. 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encodeId=bb87221380d6, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/04/987ab7c2833e61f380d4bd473e6d53ad.jpg, createdBy=9f6e1919285, createdName=好好先, createdTime=Wed Jul 12 10:29:57 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-07-17 jyzxjiangqin

    正常脑血管搏动。

    0

  5. 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encodeId=bb87221380d6, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/04/987ab7c2833e61f380d4bd473e6d53ad.jpg, createdBy=9f6e1919285, createdName=好好先, createdTime=Wed Jul 12 10:29:57 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-07-13 baihao215

    学习了，谢谢！

    0

  6. 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encodeId=bb87221380d6, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/04/987ab7c2833e61f380d4bd473e6d53ad.jpg, createdBy=9f6e1919285, createdName=好好先, createdTime=Wed Jul 12 10:29:57 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-07-13 mgqwxj

    #微血管#

    0

  7. 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target=_blank style='color:#2F92EE;'>#微血管病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50792, encryptionId=a9ff50e92ed, topicName=微血管病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32a18916252, createdName=longqijun251, createdTime=Thu Jul 13 05:43:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221525, encodeId=e58422152535, content=学习了，微梗死，也很常见。, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C3426ED027FF661B0C576A5B3127C2E8/40, createdBy=39dc1706090, createdName=QQ25ed180f, createdTime=Wed Jul 12 21:38:18 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221380, encodeId=bb87221380d6, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/04/987ab7c2833e61f380d4bd473e6d53ad.jpg, createdBy=9f6e1919285, createdName=好好先, createdTime=Wed Jul 12 10:29:57 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-07-13 124987c6m36暂无昵称

    #血管病变#

    0

  8. 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target=_blank style='color:#2F92EE;'>#微血管病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50792, encryptionId=a9ff50e92ed, topicName=微血管病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32a18916252, createdName=longqijun251, createdTime=Thu Jul 13 05:43:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221525, encodeId=e58422152535, content=学习了，微梗死，也很常见。, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C3426ED027FF661B0C576A5B3127C2E8/40, createdBy=39dc1706090, createdName=QQ25ed180f, createdTime=Wed Jul 12 21:38:18 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221380, encodeId=bb87221380d6, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/04/987ab7c2833e61f380d4bd473e6d53ad.jpg, createdBy=9f6e1919285, createdName=好好先, createdTime=Wed Jul 12 10:29:57 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-07-13 longqijun251

    #微血管病变#

    0

  9. 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encodeId=bb87221380d6, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/04/987ab7c2833e61f380d4bd473e6d53ad.jpg, createdBy=9f6e1919285, createdName=好好先, createdTime=Wed Jul 12 10:29:57 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-07-12 QQ25ed180f

    学习了，微梗死，也很常见。

    0

  10. 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target=_blank style='color:#2F92EE;'>#微血管病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50792, encryptionId=a9ff50e92ed, topicName=微血管病变)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32a18916252, createdName=longqijun251, createdTime=Thu Jul 13 05:43:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221525, encodeId=e58422152535, content=学习了，微梗死，也很常见。, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C3426ED027FF661B0C576A5B3127C2E8/40, createdBy=39dc1706090, createdName=QQ25ed180f, createdTime=Wed Jul 12 21:38:18 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221380, encodeId=bb87221380d6, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/04/987ab7c2833e61f380d4bd473e6d53ad.jpg, createdBy=9f6e1919285, createdName=好好先, createdTime=Wed Jul 12 10:29:57 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-07-12 好好先

    很好

    0

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