Radiology: LI-RADS分类告诉你原发肝癌是哪种类型!

2019-04-27 shaosai MedSci原创

本研究旨在评价原发肝细胞肝癌患者LI-RADS对术后预后意义,验证LI-RADS 2017版在鉴别钆塞酸增强MRI检查中肝细胞肝癌(HCC)与肝内胆管细胞癌(IHCC)及混合肝细胞-胆管细胞癌(cHCC-CC)的价值。

本研究旨在评价原发肝细胞肝癌患者LI-RADS对术后预后意义,验证LI-RADS 2017版在鉴别钆塞酸增强MRI检查中肝细胞肝癌(HCC)与肝内胆管细胞癌(IHCC)及混合肝细胞-胆管细胞癌(cHCC-CC)的价值。

本研究共纳入了194例肝硬化并手术证实为单发原发肝癌的患者(53例cHCC-CC、 44例IHCC和97例HCC患者),并行钆塞酸增强MRI检查。患者平均年龄为57岁,共有155名男性。由2名阅片者对每个结节进行LI-RADS分类。利用Kaplan-Meier法、Log等级检验和Cox比例危害模型评价整体生存期(OS)无复发生存期(RFS)和其相关指标。

结果为,在多元分析中,LI-RADS是OS (OR为 4.2; P < .001)、RFS(OR为2.6; P = .01)的独立指标。LR-M分类显示OS越差与RFS的相关性要强于LR-4或LR-5分类(P < .001)。LR-5分类对诊断HCC的敏感性和特异性分别为69% (67/97) 、 87% (84/97),其中的大假阳性诊断为cHCC-CCs的错误分类(85%, 11/13)。

本研究表明,LI-RADS分类与原发肝癌术后预后意义具有相关性。LI-RADS能够正确对肝细胞肝癌、肝内胆管细胞癌进行分类,但对于鉴别混合肝细胞胆管细胞癌尚不可靠。

原始出处:

Choi SH, Lee SS, Park SH,et al.LI-RADS Classification and Prognosis of Primary Liver Cancers at Gadoxetic Acid-enhanced MRI.Radiology.DOI:10.1148/radiol.2018181290

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1940292, encodeId=95111940292df, content=<a href='/topic/show?id=b176108e141' target=_blank style='color:#2F92EE;'>#LI-RADS分类#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10871, encryptionId=b176108e141, topicName=LI-RADS分类)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Mon Dec 02 19:31:00 CST 2019, time=2019-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792987, encodeId=c4b31e9298730, content=<a href='/topic/show?id=6d7e150911e' target=_blank style='color:#2F92EE;'>#RADS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15091, encryptionId=6d7e150911e, topicName=RADS)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Fri Oct 04 21:31:00 CST 2019, time=2019-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029517, encodeId=3762202951e52, content=<a href='/topic/show?id=c4222014ff' target=_blank style='color:#2F92EE;'>#ADS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2014, encryptionId=c4222014ff, topicName=ADS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38232500109, createdName=1249898am15暂无昵称, createdTime=Thu Aug 01 09:31:00 CST 2019, time=2019-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746779, encodeId=bb411e46779c4, content=<a href='/topic/show?id=a4e2108e086' target=_blank style='color:#2F92EE;'>#LI-RADS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10870, encryptionId=a4e2108e086, topicName=LI-RADS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65a635842372, createdName=zhanfl, createdTime=Tue Oct 22 13:31:00 CST 2019, time=2019-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040184, encodeId=fe3e10401842c, content=肝癌,接下来就要细分了,对于体质好的病人,能否将PD-1类+抗血管新生+放疗等相结合,甚至有必要用TACE进行减负, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=留走人康, createdTime=Sat Apr 27 19:31:00 CST 2019, time=2019-04-27, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1940292, encodeId=95111940292df, content=<a href='/topic/show?id=b176108e141' target=_blank style='color:#2F92EE;'>#LI-RADS分类#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10871, encryptionId=b176108e141, topicName=LI-RADS分类)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Mon Dec 02 19:31:00 CST 2019, time=2019-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792987, encodeId=c4b31e9298730, content=<a href='/topic/show?id=6d7e150911e' target=_blank style='color:#2F92EE;'>#RADS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15091, encryptionId=6d7e150911e, topicName=RADS)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Fri Oct 04 21:31:00 CST 2019, time=2019-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029517, encodeId=3762202951e52, content=<a href='/topic/show?id=c4222014ff' target=_blank style='color:#2F92EE;'>#ADS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2014, encryptionId=c4222014ff, topicName=ADS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38232500109, createdName=1249898am15暂无昵称, createdTime=Thu Aug 01 09:31:00 CST 2019, time=2019-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746779, encodeId=bb411e46779c4, content=<a href='/topic/show?id=a4e2108e086' target=_blank style='color:#2F92EE;'>#LI-RADS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10870, encryptionId=a4e2108e086, topicName=LI-RADS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65a635842372, createdName=zhanfl, createdTime=Tue Oct 22 13:31:00 CST 2019, time=2019-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040184, encodeId=fe3e10401842c, content=肝癌,接下来就要细分了,对于体质好的病人,能否将PD-1类+抗血管新生+放疗等相结合,甚至有必要用TACE进行减负, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=留走人康, createdTime=Sat Apr 27 19:31:00 CST 2019, time=2019-04-27, status=1, ipAttribution=)]
    2019-10-04 江川靖瑶
  3. [GetPortalCommentsPageByObjectIdResponse(id=1940292, encodeId=95111940292df, content=<a href='/topic/show?id=b176108e141' target=_blank style='color:#2F92EE;'>#LI-RADS分类#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10871, encryptionId=b176108e141, topicName=LI-RADS分类)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Mon Dec 02 19:31:00 CST 2019, time=2019-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792987, encodeId=c4b31e9298730, content=<a href='/topic/show?id=6d7e150911e' target=_blank style='color:#2F92EE;'>#RADS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15091, encryptionId=6d7e150911e, topicName=RADS)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Fri Oct 04 21:31:00 CST 2019, time=2019-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029517, encodeId=3762202951e52, content=<a href='/topic/show?id=c4222014ff' target=_blank style='color:#2F92EE;'>#ADS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2014, encryptionId=c4222014ff, topicName=ADS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38232500109, createdName=1249898am15暂无昵称, createdTime=Thu Aug 01 09:31:00 CST 2019, time=2019-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746779, encodeId=bb411e46779c4, content=<a href='/topic/show?id=a4e2108e086' target=_blank style='color:#2F92EE;'>#LI-RADS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10870, encryptionId=a4e2108e086, topicName=LI-RADS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65a635842372, createdName=zhanfl, createdTime=Tue Oct 22 13:31:00 CST 2019, time=2019-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040184, encodeId=fe3e10401842c, content=肝癌,接下来就要细分了,对于体质好的病人,能否将PD-1类+抗血管新生+放疗等相结合,甚至有必要用TACE进行减负, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=留走人康, createdTime=Sat Apr 27 19:31:00 CST 2019, time=2019-04-27, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1940292, encodeId=95111940292df, content=<a href='/topic/show?id=b176108e141' target=_blank style='color:#2F92EE;'>#LI-RADS分类#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10871, encryptionId=b176108e141, topicName=LI-RADS分类)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Mon Dec 02 19:31:00 CST 2019, time=2019-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792987, encodeId=c4b31e9298730, content=<a href='/topic/show?id=6d7e150911e' target=_blank style='color:#2F92EE;'>#RADS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15091, encryptionId=6d7e150911e, topicName=RADS)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Fri Oct 04 21:31:00 CST 2019, time=2019-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029517, encodeId=3762202951e52, content=<a href='/topic/show?id=c4222014ff' target=_blank style='color:#2F92EE;'>#ADS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2014, encryptionId=c4222014ff, topicName=ADS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38232500109, createdName=1249898am15暂无昵称, createdTime=Thu Aug 01 09:31:00 CST 2019, time=2019-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746779, encodeId=bb411e46779c4, content=<a href='/topic/show?id=a4e2108e086' target=_blank style='color:#2F92EE;'>#LI-RADS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10870, encryptionId=a4e2108e086, topicName=LI-RADS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65a635842372, createdName=zhanfl, createdTime=Tue Oct 22 13:31:00 CST 2019, time=2019-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040184, encodeId=fe3e10401842c, content=肝癌,接下来就要细分了,对于体质好的病人,能否将PD-1类+抗血管新生+放疗等相结合,甚至有必要用TACE进行减负, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=留走人康, createdTime=Sat Apr 27 19:31:00 CST 2019, time=2019-04-27, status=1, ipAttribution=)]
    2019-10-22 zhanfl
  5. [GetPortalCommentsPageByObjectIdResponse(id=1940292, encodeId=95111940292df, content=<a href='/topic/show?id=b176108e141' target=_blank style='color:#2F92EE;'>#LI-RADS分类#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10871, encryptionId=b176108e141, topicName=LI-RADS分类)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Mon Dec 02 19:31:00 CST 2019, time=2019-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792987, encodeId=c4b31e9298730, content=<a href='/topic/show?id=6d7e150911e' target=_blank style='color:#2F92EE;'>#RADS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15091, encryptionId=6d7e150911e, topicName=RADS)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK17mLkWpia3T92NlEWTkEhrhZa7XPNic2JqQumEicZXGYFG6Ww5SCIl0Uq62bhhPnibAqIZDHtRva92A/132, createdBy=e0752500025, createdName=江川靖瑶, createdTime=Fri Oct 04 21:31:00 CST 2019, time=2019-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029517, encodeId=3762202951e52, content=<a href='/topic/show?id=c4222014ff' target=_blank style='color:#2F92EE;'>#ADS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2014, encryptionId=c4222014ff, topicName=ADS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38232500109, createdName=1249898am15暂无昵称, createdTime=Thu Aug 01 09:31:00 CST 2019, time=2019-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1746779, encodeId=bb411e46779c4, content=<a href='/topic/show?id=a4e2108e086' target=_blank style='color:#2F92EE;'>#LI-RADS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10870, encryptionId=a4e2108e086, topicName=LI-RADS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=65a635842372, createdName=zhanfl, createdTime=Tue Oct 22 13:31:00 CST 2019, time=2019-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040184, encodeId=fe3e10401842c, content=肝癌,接下来就要细分了,对于体质好的病人,能否将PD-1类+抗血管新生+放疗等相结合,甚至有必要用TACE进行减负, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=留走人康, createdTime=Sat Apr 27 19:31:00 CST 2019, time=2019-04-27, status=1, ipAttribution=)]
    2019-04-27 留走人康

    肝癌,接下来就要细分了,对于体质好的病人,能否将PD-1类+抗血管新生+放疗等相结合,甚至有必要用TACE进行减负

    0

相关资讯

病例分享:肝硬化合并凝血因子Ⅶ缺乏

患者无腹痛、腹胀、腹泻等症状,否认抗凝药物及毒物摄入史,无手术、出血及输血史,无异常出血家族病史。

Lancet Gastroen Hepatol:APRI以及FIB-4检测法用于无创肝硬化检查的临床意义

研究认为,传统的APRI以及FIB-4检测标准因其较高的误诊率无法作为肝硬化无创活检的手段,调整FIB-4标准≤0.7可显著增加诊断准确性

新研究显示,英国青年人中非酒精性脂肪肝的发病率高达20%

新的研究显示,英国年轻人中非酒精性脂肪性肝病(NAFLD)患病率奇高,其中40%已经进展为纤维化。该研究内容由布里斯托尔大学在2019年奥地利维也纳举行的国际肝病大会上发布。

多种心脏疾病合并肝硬化失代偿期老年患者行乙状结肠癌根治术的围术期管理和多学科诊疗一例

患者男,70岁,体重69kg,身高168 cm,BMI为24kg/m2。因“大便次数增多1年余,发现结肠肿物6d”,于2017年12月7日入院。外院病理学检查诊断为乙状结肠腺癌,拟入院行腹腔镜乙状结肠癌根治术。患者既往有糖尿病史10年,目前接受精蛋白生物合成人胰岛素注射液(商品名诺和灵30R)早9U和晚11U治疗,空腹血糖控制在6.6mmol/L;有冠状动脉性心脏病(以下简称冠心病)史4年,201

Cell:揭示出肝硬化中的复杂突变景观

正常组织随着年龄的增长而累积遗传变化,但是在慢性退行性疾病的情况下,体细胞突变是否促进非恶性细胞的克隆扩增(clonal expansion)尚不清楚。