JAHA:辅助生殖技术妊娠的院内并发症

2022-02-24 MedSci原创 MedSci原创

与自然受孕相比,通过辅助生殖技术受孕的妊娠发生不良产科结局和血管并发症的风险更高。临床医生应在孕前咨询期间详细讨论女性辅助生殖技术的相关并发症。

辅助生殖技术已成为不孕症常见的治疗手段,不孕症这一问题已影响到全球约4800万对夫妇。随着孕前心血管危险因素(如慢性高血压、肥胖和糖尿病)的增加,孕产妇年龄的增加引起了人们对与辅助生殖技术相关的妊娠并发症的担忧。辅助生殖技术是一组治疗不孕症的医疗操作,其中包括控制排卵时间的药物,以及体外受精 (IVF) 和胞浆内精子注射 (ICSI) 等程序。 迄今为止,全球超过500万婴儿通过辅助生殖技术出生。然而,辅助生殖技术怀孕后的院内并发症却鲜有描述。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在评估接受辅助生殖技术后怀孕的患者特征、产科结局、血管并发症和时间趋势。研究人员从美国国家住院患者样本数据库中分析了2008年1月1日至2016年12月31日期间接受或不接受辅助生殖技术的医院分娩情况。

研究人员纳入了106248例接受辅助生殖技术的分娩和34167246例未接受辅助生殖技术的分娩病例。接受辅助生殖技术的女性年龄较大(35岁 vs. 28岁;P<0.0001)并且合并症较多。

辅助生殖技术妊娠与血管并发症(急性肾损伤:调整比值比[aOR]为2.52;95%CI为1.99-3.19;心律失常:aOR为1.65;95%CI为1.46-1.86)和不良产科结局独立相关(胎盘早剥:aOR为1.57;95%CI为1.41-1.74;剖宫产:aOR为1.38;95%CI为1.33-1.43;早产:aOR为1.26;95%CI为1.20-1.32),纳入了没有心血管疾病危险因素或没有多胎妊娠的亚组也是如此。与未接受辅助生殖技术的妊娠女性相比,辅助生殖技术的妊娠女性住院费用较高(18705美元 vs. 11983美元;P<0.0001)。

由此可见,与自然受孕相比,通过辅助生殖技术受孕的妊娠发生不良产科结局和血管并发症的风险更高。临床医生应在孕前咨询期间详细讨论女性辅助生殖技术的相关并发症。

原始出处:

Pensée Wu.et al.In‐Hospital Complications in Pregnancies Conceived by Assisted Reproductive Technology.JAHA.2022.https://www.ahajournals.org/doi/full/10.1161/JAHA.121.022658

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    2022-10-15 丁鹏鹏
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    2022-02-25 zhaohui6731
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    2022-02-24 ms5000000785803895

    #学习#学到啦

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