赛诺菲、再生元的Dupixent在慢性自发性荨麻疹中取得积极成果

2021-08-02 Allan MedSci原创

慢性自发性荨麻疹(CSU)也称慢性特发性荨麻疹,定义为一周内大多数时间存在荨麻疹并且这种情况持续6周或以上。大约40%的患者伴发血管性水肿。

慢性自发性荨麻疹(CSU)也称慢性特发性荨麻疹,定义为一周内大多数时间存在荨麻疹并且这种情况持续6周或以上。大约40%的患者伴发血管性水肿。CSU的特点是皮肤上突然出现荨麻疹并在皮下深处肿胀,这种肿胀经常发生在面部、手和脚上,还会影响喉咙和上呼吸道。CSU的标准治疗主要为第二代H1抗组胺药,常采用高于常规的剂量,并联合H2抗组胺药和白三烯调节剂。尽管该病症通常用抗组胺药治疗,但对于多达50%的治疗选择有限的患者来说,该疾病仍未得到控制。

pastedGraphic.png

图1.慢性自发性荨麻疹患者的血管性水肿

赛诺菲和再生元的白细胞介素-4 (IL-4) 和白介素-13 (IL-13) 抑制剂Dupixent(图2)已在慢性自发性荨麻疹 (CSU) 显示出积极的关键结果。

在中度至重度CSU患者中评估Dupixent (dupilumab) 的III期试验达到了其主要和所有关键次要终点,IL-4/IL-13抑制剂Dupixent在添加到未使用生物制剂的患者的标准护理后,显著减少了瘙痒和荨麻疹。具体而言,与安慰剂相比,将Dupixent添加到标准护理抗组胺药中可将瘙痒严重程度降低63%,这是通过0-21点瘙痒严重程度量表衡量的。

最重要的是,根据0-42点荨麻疹活动量表,Dupixent添加到标准护理后,使荨麻疹活动(瘙痒和荨麻疹)的严重程度降低了65%,而安慰剂组则只降低了37%。

图2.Dupixent的作用机制

再生元总裁兼首席科学官George D. Yancopoulos说:“这个数据增加了越来越多的证据,表明 Dupixent可以减轻各种皮肤病、呼吸系统和胃肠道疾病的疾病负担”。

两家公司在一份声明中表示,CSU是Dupixent拥有积极III期数据的第五种疾病,其他的Dupixent适应症包括特应性皮炎、哮喘、慢性鼻窦炎伴鼻息肉病和嗜酸性粒细胞性食管炎。

 

原始出处:

http://www.pharmatimes.com/news/sanofi,_regenerons_dupixent_wins_positive_results_in_chronic_spontaneous_urticaria_1373790

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (8)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1784848, encodeId=572b1e84848ae, content=<a href='/topic/show?id=00e4633166' target=_blank style='color:#2F92EE;'>#Dupixen#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6331, encryptionId=00e4633166, topicName=Dupixen)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Wed Oct 27 22:22:43 CST 2021, time=2021-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355599, encodeId=fcef135559946, content=<a href='/topic/show?id=0ff310302082' target=_blank style='color:#2F92EE;'>#麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103020, encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372751, encodeId=85ad13e27519e, content=<a href='/topic/show?id=91a7633258' target=_blank style='color:#2F92EE;'>#Dupixent#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6332, encryptionId=91a7633258, topicName=Dupixent)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2a44345, createdName=yulin2006, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378797, encodeId=f82d13e879786, content=<a href='/topic/show?id=f263536e74f' target=_blank style='color:#2F92EE;'>#慢性自发性荨麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53677, encryptionId=f263536e74f, topicName=慢性自发性荨麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530634, encodeId=e39d153063497, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004568, encodeId=4d5e100456829, content=好恐怖,祝福, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210901/969603a2377544169c0528539edd5ab7/50bbe992202d43569f6cc40d89829e36.jpg, createdBy=b54c5537441, createdName=智慧药, createdTime=Mon Aug 02 09:52:05 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004557, encodeId=a2e3100455e1a, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e8212476654, createdName=1244c0ebm28暂无昵称, createdTime=Mon Aug 02 09:15:56 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004521, encodeId=e6d8100452138, content=认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b3545492917, createdName=smart Ren, createdTime=Mon Aug 02 05:55:01 CST 2021, time=2021-08-02, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1784848, encodeId=572b1e84848ae, content=<a href='/topic/show?id=00e4633166' target=_blank style='color:#2F92EE;'>#Dupixen#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6331, encryptionId=00e4633166, topicName=Dupixen)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Wed Oct 27 22:22:43 CST 2021, time=2021-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355599, encodeId=fcef135559946, content=<a href='/topic/show?id=0ff310302082' target=_blank style='color:#2F92EE;'>#麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103020, encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372751, encodeId=85ad13e27519e, content=<a href='/topic/show?id=91a7633258' target=_blank style='color:#2F92EE;'>#Dupixent#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6332, encryptionId=91a7633258, topicName=Dupixent)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2a44345, createdName=yulin2006, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378797, encodeId=f82d13e879786, content=<a href='/topic/show?id=f263536e74f' target=_blank style='color:#2F92EE;'>#慢性自发性荨麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53677, encryptionId=f263536e74f, topicName=慢性自发性荨麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530634, encodeId=e39d153063497, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004568, encodeId=4d5e100456829, content=好恐怖,祝福, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210901/969603a2377544169c0528539edd5ab7/50bbe992202d43569f6cc40d89829e36.jpg, createdBy=b54c5537441, createdName=智慧药, createdTime=Mon Aug 02 09:52:05 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004557, encodeId=a2e3100455e1a, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e8212476654, createdName=1244c0ebm28暂无昵称, createdTime=Mon Aug 02 09:15:56 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004521, encodeId=e6d8100452138, content=认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b3545492917, createdName=smart Ren, createdTime=Mon Aug 02 05:55:01 CST 2021, time=2021-08-02, status=1, ipAttribution=)]
    2021-08-03 zhaojie88
  3. [GetPortalCommentsPageByObjectIdResponse(id=1784848, encodeId=572b1e84848ae, content=<a href='/topic/show?id=00e4633166' target=_blank style='color:#2F92EE;'>#Dupixen#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6331, encryptionId=00e4633166, topicName=Dupixen)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Wed Oct 27 22:22:43 CST 2021, time=2021-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355599, encodeId=fcef135559946, content=<a href='/topic/show?id=0ff310302082' target=_blank style='color:#2F92EE;'>#麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103020, encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372751, encodeId=85ad13e27519e, content=<a href='/topic/show?id=91a7633258' target=_blank style='color:#2F92EE;'>#Dupixent#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6332, encryptionId=91a7633258, topicName=Dupixent)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2a44345, createdName=yulin2006, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378797, encodeId=f82d13e879786, content=<a href='/topic/show?id=f263536e74f' target=_blank style='color:#2F92EE;'>#慢性自发性荨麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53677, encryptionId=f263536e74f, topicName=慢性自发性荨麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530634, encodeId=e39d153063497, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004568, encodeId=4d5e100456829, content=好恐怖,祝福, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210901/969603a2377544169c0528539edd5ab7/50bbe992202d43569f6cc40d89829e36.jpg, createdBy=b54c5537441, createdName=智慧药, createdTime=Mon Aug 02 09:52:05 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004557, encodeId=a2e3100455e1a, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e8212476654, createdName=1244c0ebm28暂无昵称, createdTime=Mon Aug 02 09:15:56 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004521, encodeId=e6d8100452138, content=认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b3545492917, createdName=smart Ren, createdTime=Mon Aug 02 05:55:01 CST 2021, time=2021-08-02, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1784848, encodeId=572b1e84848ae, content=<a href='/topic/show?id=00e4633166' target=_blank style='color:#2F92EE;'>#Dupixen#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6331, encryptionId=00e4633166, topicName=Dupixen)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Wed Oct 27 22:22:43 CST 2021, time=2021-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355599, encodeId=fcef135559946, content=<a href='/topic/show?id=0ff310302082' target=_blank style='color:#2F92EE;'>#麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103020, encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372751, encodeId=85ad13e27519e, content=<a href='/topic/show?id=91a7633258' target=_blank style='color:#2F92EE;'>#Dupixent#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6332, encryptionId=91a7633258, topicName=Dupixent)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2a44345, createdName=yulin2006, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378797, encodeId=f82d13e879786, content=<a href='/topic/show?id=f263536e74f' target=_blank style='color:#2F92EE;'>#慢性自发性荨麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53677, encryptionId=f263536e74f, topicName=慢性自发性荨麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530634, encodeId=e39d153063497, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004568, encodeId=4d5e100456829, content=好恐怖,祝福, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210901/969603a2377544169c0528539edd5ab7/50bbe992202d43569f6cc40d89829e36.jpg, createdBy=b54c5537441, createdName=智慧药, createdTime=Mon Aug 02 09:52:05 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004557, encodeId=a2e3100455e1a, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e8212476654, createdName=1244c0ebm28暂无昵称, createdTime=Mon Aug 02 09:15:56 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004521, encodeId=e6d8100452138, content=认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b3545492917, createdName=smart Ren, createdTime=Mon Aug 02 05:55:01 CST 2021, time=2021-08-02, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1784848, encodeId=572b1e84848ae, content=<a href='/topic/show?id=00e4633166' target=_blank style='color:#2F92EE;'>#Dupixen#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6331, encryptionId=00e4633166, topicName=Dupixen)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Wed Oct 27 22:22:43 CST 2021, time=2021-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355599, encodeId=fcef135559946, content=<a href='/topic/show?id=0ff310302082' target=_blank style='color:#2F92EE;'>#麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103020, encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372751, encodeId=85ad13e27519e, content=<a href='/topic/show?id=91a7633258' target=_blank style='color:#2F92EE;'>#Dupixent#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6332, encryptionId=91a7633258, topicName=Dupixent)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2a44345, createdName=yulin2006, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378797, encodeId=f82d13e879786, content=<a href='/topic/show?id=f263536e74f' target=_blank style='color:#2F92EE;'>#慢性自发性荨麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53677, encryptionId=f263536e74f, topicName=慢性自发性荨麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530634, encodeId=e39d153063497, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004568, encodeId=4d5e100456829, content=好恐怖,祝福, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210901/969603a2377544169c0528539edd5ab7/50bbe992202d43569f6cc40d89829e36.jpg, createdBy=b54c5537441, createdName=智慧药, createdTime=Mon Aug 02 09:52:05 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004557, encodeId=a2e3100455e1a, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e8212476654, createdName=1244c0ebm28暂无昵称, createdTime=Mon Aug 02 09:15:56 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004521, encodeId=e6d8100452138, content=认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b3545492917, createdName=smart Ren, createdTime=Mon Aug 02 05:55:01 CST 2021, time=2021-08-02, status=1, ipAttribution=)]
    2021-08-03 sodoo
  6. [GetPortalCommentsPageByObjectIdResponse(id=1784848, encodeId=572b1e84848ae, content=<a href='/topic/show?id=00e4633166' target=_blank style='color:#2F92EE;'>#Dupixen#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6331, encryptionId=00e4633166, topicName=Dupixen)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Wed Oct 27 22:22:43 CST 2021, time=2021-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355599, encodeId=fcef135559946, content=<a href='/topic/show?id=0ff310302082' target=_blank style='color:#2F92EE;'>#麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103020, encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372751, encodeId=85ad13e27519e, content=<a href='/topic/show?id=91a7633258' target=_blank style='color:#2F92EE;'>#Dupixent#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6332, encryptionId=91a7633258, topicName=Dupixent)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2a44345, createdName=yulin2006, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378797, encodeId=f82d13e879786, content=<a href='/topic/show?id=f263536e74f' target=_blank style='color:#2F92EE;'>#慢性自发性荨麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53677, encryptionId=f263536e74f, topicName=慢性自发性荨麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530634, encodeId=e39d153063497, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004568, encodeId=4d5e100456829, content=好恐怖,祝福, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210901/969603a2377544169c0528539edd5ab7/50bbe992202d43569f6cc40d89829e36.jpg, createdBy=b54c5537441, createdName=智慧药, createdTime=Mon Aug 02 09:52:05 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004557, encodeId=a2e3100455e1a, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e8212476654, createdName=1244c0ebm28暂无昵称, createdTime=Mon Aug 02 09:15:56 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004521, encodeId=e6d8100452138, content=认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b3545492917, createdName=smart Ren, createdTime=Mon Aug 02 05:55:01 CST 2021, time=2021-08-02, status=1, ipAttribution=)]
    2021-08-02 智慧药

    好恐怖,祝福

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1784848, encodeId=572b1e84848ae, content=<a href='/topic/show?id=00e4633166' target=_blank style='color:#2F92EE;'>#Dupixen#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6331, encryptionId=00e4633166, topicName=Dupixen)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Wed Oct 27 22:22:43 CST 2021, time=2021-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355599, encodeId=fcef135559946, content=<a href='/topic/show?id=0ff310302082' target=_blank style='color:#2F92EE;'>#麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103020, encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372751, encodeId=85ad13e27519e, content=<a href='/topic/show?id=91a7633258' target=_blank style='color:#2F92EE;'>#Dupixent#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6332, encryptionId=91a7633258, topicName=Dupixent)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2a44345, createdName=yulin2006, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378797, encodeId=f82d13e879786, content=<a href='/topic/show?id=f263536e74f' target=_blank style='color:#2F92EE;'>#慢性自发性荨麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53677, encryptionId=f263536e74f, topicName=慢性自发性荨麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530634, encodeId=e39d153063497, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004568, encodeId=4d5e100456829, content=好恐怖,祝福, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210901/969603a2377544169c0528539edd5ab7/50bbe992202d43569f6cc40d89829e36.jpg, createdBy=b54c5537441, createdName=智慧药, createdTime=Mon Aug 02 09:52:05 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004557, encodeId=a2e3100455e1a, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e8212476654, createdName=1244c0ebm28暂无昵称, createdTime=Mon Aug 02 09:15:56 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004521, encodeId=e6d8100452138, content=认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b3545492917, createdName=smart Ren, createdTime=Mon Aug 02 05:55:01 CST 2021, time=2021-08-02, status=1, ipAttribution=)]
    2021-08-02 1244c0ebm28暂无昵称

    学习学习

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1784848, encodeId=572b1e84848ae, content=<a href='/topic/show?id=00e4633166' target=_blank style='color:#2F92EE;'>#Dupixen#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6331, encryptionId=00e4633166, topicName=Dupixen)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35fc2500023, createdName=yanjie6253_56072842, createdTime=Wed Oct 27 22:22:43 CST 2021, time=2021-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355599, encodeId=fcef135559946, content=<a href='/topic/show?id=0ff310302082' target=_blank style='color:#2F92EE;'>#麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103020, encryptionId=0ff310302082, topicName=麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372751, encodeId=85ad13e27519e, content=<a href='/topic/show?id=91a7633258' target=_blank style='color:#2F92EE;'>#Dupixent#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6332, encryptionId=91a7633258, topicName=Dupixent)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2a44345, createdName=yulin2006, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1378797, encodeId=f82d13e879786, content=<a href='/topic/show?id=f263536e74f' target=_blank style='color:#2F92EE;'>#慢性自发性荨麻疹#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53677, encryptionId=f263536e74f, topicName=慢性自发性荨麻疹)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530634, encodeId=e39d153063497, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=584a12117168, createdName=sodoo, createdTime=Tue Aug 03 20:22:43 CST 2021, time=2021-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004568, encodeId=4d5e100456829, content=好恐怖,祝福, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210901/969603a2377544169c0528539edd5ab7/50bbe992202d43569f6cc40d89829e36.jpg, createdBy=b54c5537441, createdName=智慧药, createdTime=Mon Aug 02 09:52:05 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004557, encodeId=a2e3100455e1a, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e8212476654, createdName=1244c0ebm28暂无昵称, createdTime=Mon Aug 02 09:15:56 CST 2021, time=2021-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004521, encodeId=e6d8100452138, content=认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b3545492917, createdName=smart Ren, createdTime=Mon Aug 02 05:55:01 CST 2021, time=2021-08-02, status=1, ipAttribution=)]
    2021-08-02 smart Ren

    认真学习

    0

相关资讯

Dupixent在欧盟获得批准用于儿童特应性皮炎

欧盟委员会已批准赛诺菲和再生元的生物制剂Dupixent,允许其用于治疗6至11岁的儿童特应性皮炎。

赛诺菲/再生元Dupixent获FDA突破性疗法认定

据外媒报道,昨日,美国FDA授予了赛诺菲/再生元Dupixent(dupilumab,度普利尤单抗)突破性治疗指定,用于治疗12岁及以上的嗜酸性粒细胞性食管炎(EoE)患者。此次认定基于对EoE患者进

中国NMPA批准Dupixent用于特应性皮炎

赛诺菲和再生元制药公司近日宣布,中国国家药品监督管理局(NMPA)批准了Dupixent(dupilumab)治疗无法通过局部处方药或适当疗法进行控制的特应性皮炎(AD)患者。

美国临床医生最喜欢用哪种哮喘生物药?

从罗氏(Roche)和诺华(Novartis)的Xolair(奥马珠单抗:靶向IgE)到赛诺菲(Sanofi)和再生元的Dupixent(dupilumab,靶向IL-4和IL-13),以及阿斯利康(AstraZeneca)的Fasenra(benralizumab,靶向IL-5Rα)和葛兰素史克(GlaxoSmithKline)的Nucala(美泊利单抗,靶向IL-5),几种生物制剂正在争夺哮喘

慢性皮肤病及呼吸道疾病患者的福音:FDA批准Dupixent(dupilumab)300mg预填充笔

近日,美国FDA已批准Dupixent(dupilumab)300mg单剂量预填充笔,用于12岁及以上患者的所有Dupixent适应症。

哮喘新药:再生元的Dupixent能够迅速改善儿童的肺功能

VOYAGE试验评估了Dupixent联合标准护理(SoC)在408例中度至重度哮喘不受控制的患儿中的安全性和有效性。

拓展阅读

赛诺菲/再生元的Dupixent在第二次慢性自发性荨麻疹研究中表现欠佳

赛诺菲和再生元制药本周五表示,基于预先指定的中期分析,Dupixent (dupilumab) 用于慢性自发性荨麻疹 (CSU) 患者的 III 期研究将因无效而停止。

幼儿哮喘患者的福音,CHMP批准Dupixent用于患有哮喘的幼儿患者

Dupilumab是一种人IgG4抗体,能够抗IL-4受体 (IL-4R) α亚基,可阻断由IL-4和IL-13诱导的IL-4R信号传导,下调驱动2型炎症性疾病的分子途径。

哮喘新药:再生元的Dupixent能够迅速改善儿童的肺功能

VOYAGE试验评估了Dupixent联合标准护理(SoC)在408例中度至重度哮喘不受控制的患儿中的安全性和有效性。

Dupixent在欧盟获得批准用于儿童特应性皮炎

欧盟委员会已批准赛诺菲和再生元的生物制剂Dupixent,允许其用于治疗6至11岁的儿童特应性皮炎。

赛诺菲/再生元Dupixent获FDA突破性疗法认定

据外媒报道,昨日,美国FDA授予了赛诺菲/再生元Dupixent(dupilumab,度普利尤单抗)突破性治疗指定,用于治疗12岁及以上的嗜酸性粒细胞性食管炎(EoE)患者。此次认定基于对EoE患者进

慢性皮肤病及呼吸道疾病患者的福音:FDA批准Dupixent(dupilumab)300mg预填充笔

近日,美国FDA已批准Dupixent(dupilumab)300mg单剂量预填充笔,用于12岁及以上患者的所有Dupixent适应症。