入不敷出,利“干”见影,一文搞定心衰容量管理!

2018-06-08 英硕 医学界心血管频道

心力衰竭(简称心衰)本身不是一种疾病,而一组临床综合征,任何心血管疾病发展到晚期均可引起心衰。根据定义可以了解心衰是由各种原因导致心室收缩或舒张功能下降,病理生理学上表现为肺淤血和(或)体循环淤血,临床上表现为呼吸困难(肺淤血)、乏力(组织低灌注)以及外周水肿(液体潴留)等。

心力衰竭(简称心衰)本身不是一种疾病,而一组临床综合征,任何心血管疾病发展到晚期均可引起心衰。根据定义可以了解心衰是由各种原因导致心室收缩或舒张功能下降,病理生理学上表现为肺淤血和(或)体循环淤血,临床上表现为呼吸困难(肺淤血)、乏力(组织低灌注)以及外周水肿(液体潴留)等。

因此容量管理至关重要,既要重视入量,又要关注出量,达到出入平衡才能改善患者整体状态。记得曾经一位主任曾经幽默地表述心衰患者容量管理:心衰患者要过上“吃不上喝不上的穷日子”,总结一下就是入不敷出,立(利)竿(干)见影。

1.容量管理的重要意义

我们在临床工作中观察心衰反复住院的患者,多数是由于院外容量控制不佳,导致肺循环和体循环淤血所致。目前发现容量超负荷导致心衰患者住院的主要原因。目前各大心衰指南均将控制液体潴留,减轻容量超负荷,作为治疗充血性心衰的基石之一。

容量超负荷并非简单的概括为肺循环和体循环淤血,其中包含各脏器的功能异常(表1)。

表1 容量超负荷致各组织器官功能异常



2.容量管理具体步骤

容量管理是一项非常复杂的过程,主要分为三个步骤(图1):(1)评估容量状态;(2)制定容量管理目标;(3)选择合适处理措施。下面我们通过表2来具体描述一下容量管理步骤。


图1:容量管理的具体步骤

表2 容量管理具体步骤总结



3.常见袢利尿剂特点

表3 常见袢利尿剂特点



表4 其他口服利尿剂特用法用量



4.那么,利尿剂反应不好怎么办?

对于容量超负荷来说,利尿剂是最重要的治疗手段,但如果利尿剂治疗效果不好,我们该如何应对?

表5 利尿剂反应不良应对策略



在临床上什么情况下酸利尿剂反应不良,虽没有统一定义,但根据目前指南和专家建议,该概念通常是指每日静脉应用呋塞米剂量≥80 mg或等同剂量利尿剂,尿量<0.5~1.0 ml/kg/h。

“入不敷出,利干见影”是一门很深的学问,

需要我们综合分析,综合处理。

原始出处:

[1]中国医师协会心力衰竭专业委员会, 中华心里衰竭和心肌病杂志编辑委员会. 心力衰竭容量管理中国专家建议. 中华心里衰竭和心肌病杂志, 2018, 2(1):8-16.

[2]Ponikowski P, VoorsAA, Anker SD, et al. 2016 ESC Guidelines for the diagnosis and treatment ofacute and chronic heart failure: The Task Force for the diagnosis and treatmentof acute and chronic heart failure of the European Society of Cardiology (ESC).Developed with the special contribution of the Heart Failure Association (HFA)of the ESC. Eur J Heart Fail. 2016, 18(8):891-975.

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    2018-06-14 润泽River

    棒棒的棒棒的

    0

  3. 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    2018-06-14 润泽River

    学习

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1689774, encodeId=ce791689e74da, content=<a href='/topic/show?id=a20746490ff' target=_blank style='color:#2F92EE;'>#容量管理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46490, encryptionId=a20746490ff, topicName=容量管理)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0c28868481, createdName=12498da4m41(暂无昵称), createdTime=Sat Oct 20 02:46:00 CST 2018, time=2018-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324101, encodeId=54743241013c, content=棒棒的棒棒的, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TNV5cElot3tDNlyIMGic8HtYGcKD9cIvZR1TXRasIwjyib9BdYd3p4jcM75yvkr22FDhd6jseJmBOLaGyejic1vew/132, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sat Jun 09 10:47:22 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322757, encodeId=fd6c322e5743, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Jun 09 09:15:59 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322751, encodeId=fee2322e514a, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Sat Jun 09 09:14:54 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322736, encodeId=6820322e36ef, content=厉害了我的哥, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Jun 09 07:45:18 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322733, encodeId=1b2f322e3341, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sat Jun 09 07:43:06 CST 2018, time=2018-06-09, status=1, ipAttribution=)]
    2018-06-10 Jackie Li

    学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1689774, encodeId=ce791689e74da, content=<a href='/topic/show?id=a20746490ff' target=_blank style='color:#2F92EE;'>#容量管理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46490, encryptionId=a20746490ff, topicName=容量管理)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0c28868481, createdName=12498da4m41(暂无昵称), createdTime=Sat Oct 20 02:46:00 CST 2018, time=2018-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324101, encodeId=54743241013c, content=棒棒的棒棒的, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TNV5cElot3tDNlyIMGic8HtYGcKD9cIvZR1TXRasIwjyib9BdYd3p4jcM75yvkr22FDhd6jseJmBOLaGyejic1vew/132, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sat Jun 09 10:47:22 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322757, encodeId=fd6c322e5743, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Jun 09 09:15:59 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322751, encodeId=fee2322e514a, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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    2018-06-10 yjs木玉

    好好好好好好好好

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1689774, encodeId=ce791689e74da, content=<a href='/topic/show?id=a20746490ff' target=_blank style='color:#2F92EE;'>#容量管理#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46490, encryptionId=a20746490ff, topicName=容量管理)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0c28868481, createdName=12498da4m41(暂无昵称), createdTime=Sat Oct 20 02:46:00 CST 2018, time=2018-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=324101, encodeId=54743241013c, content=棒棒的棒棒的, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/TNV5cElot3tDNlyIMGic8HtYGcKD9cIvZR1TXRasIwjyib9BdYd3p4jcM75yvkr22FDhd6jseJmBOLaGyejic1vew/132, 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sat Jun 09 07:43:06 CST 2018, time=2018-06-09, status=1, ipAttribution=)]
    2018-06-09 医者仁心5538

    学习了

    0

  7. 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sat Jun 09 07:43:06 CST 2018, time=2018-06-09, status=1, ipAttribution=)]
    2018-06-09 龙胆草

    学习谢谢分享

    0

  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sat Jun 09 10:47:22 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322757, encodeId=fd6c322e5743, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sat Jun 09 09:15:59 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=322751, encodeId=fee2322e514a, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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    2018-06-09 smartxiuxiu

    0

  9. 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sat Jun 09 07:43:06 CST 2018, time=2018-06-09, status=1, ipAttribution=)]
    2018-06-09 飛歌

    厉害了我的哥

    0

  10. 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    2018-06-09 sunfeifeiyang

    0

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症状明显,但BNP接近正常,这到底是不是心衰啊?!

患者胡XX,M/80岁,因“活动后呼吸困难2月,加重1周”由外院转入入院。

JAHA:社会隔离会增加心衰患者死亡风险!

感知型社会隔离对人体的健康有不良的影响。本研究的目的旨在评估心衰患者的感知型社会隔离对预后的影响。本研究纳入了2013年至2015年诊断的3867名心衰患者,对其感知型社会隔离程度进行了回顾评估,其中有2003名患者对问卷进行了反馈(反馈率52%),1681名患者(男性占53%,平均年龄为73岁)回答了所有的问题,并作为本次研究的对象。分析结果显示,有312名(19%)患者有中度的感知型社会隔离,