JAMA Pediatr:生理盐水雾化与儿童急性病毒性毛细支气管炎

2020-01-07 MedSci MedSci原创

研究认为,雾化吸入生理盐水可能是急性病毒性毛细支气管炎的积极治疗手段

在急性病毒性毛细支气管炎的治疗试验中,接受生理盐水雾化(NS)作为安慰剂的患者会出现持续的临床改善, 提示NS雾化可能作为潜在的治疗手段。近日研究人员考察了NS雾化与儿童毛细支气管炎指标的相关性。

本次研究为系统综述及荟萃分析研究,收集截至2019年3月相关数据,2岁及以下接受NS雾化的毛细支气管炎患儿参与,研究的主要终点为对雾化吸入NS与另一安慰剂治疗60分钟内的呼吸评分、呼吸频率和血氧饱和度以及雾化吸入NS前后的变化进行综合评估。

共29项研究,包括1583名患者。雾化吸入NS与其他安慰剂(3项研究)在治疗60分钟后呼吸评分的标准化平均差异为-0.9分。与其他安慰剂相比,雾化吸入NS后,患儿呼吸频率和血氧饱和度没有差异。雾化吸入NS后,呼吸评分(25项研究)的标准化平均差异为-0.7。雾化NS后,使用同一评估标准(13项研究)的呼吸评分加权平均差异为-1.6分。雾化NS后的呼吸速率加权平均差异(17项研究)为-5.5次/分钟。雾化吸入NS后的氧饱和度加权平均差异(23项研究)为-0.4%。

研究认为,雾化吸入生理盐水可能是急性病毒性毛细支气管炎的积极治疗手段。

原始出处:


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  5. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553877, encodeId=6b5f15538e743, content=<a href='/topic/show?id=dc4f63695a8' target=_blank style='color:#2F92EE;'>#毛细支气管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63695, encryptionId=dc4f63695a8, topicName=毛细支气管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=be0f14453443, createdName=rebeccajiejie, createdTime=Thu Jan 09 09:38:00 CST 2020, time=2020-01-09, status=1, ipAttribution=)]
    2020-08-30 feather89
  6. 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  7. 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  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553877, encodeId=6b5f15538e743, content=<a href='/topic/show?id=dc4f63695a8' target=_blank style='color:#2F92EE;'>#毛细支气管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63695, encryptionId=dc4f63695a8, topicName=毛细支气管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=be0f14453443, createdName=rebeccajiejie, createdTime=Thu Jan 09 09:38:00 CST 2020, time=2020-01-09, status=1, ipAttribution=)]
    2020-08-11 howi
  9. 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