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J Clin Invest：缺铁增强幽门螺杆菌的致癌作用

2012-12-26 J Clin Invest CMT 银子 编译

幽门螺杆菌胃癌
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数据表明，缺铁可增强幽门螺旋杆菌毒力，它可作为一个可测定的生物标记，用来识别具有得胃癌高风险的感染者。 胃腺癌与幽门螺旋杆菌感染强相关，但大多数被感染的人不会得胃癌。幽门螺杆菌菌株包含胞嘧啶-腺嘌呤-鸟嘌呤致病基因组（CAG +），它可以编码CagA蛋白和IV型分泌系统（T4SS），从而引发更严重的疾病。幽门螺旋杆菌感染也与缺铁性贫血相关，这同样增强患胃癌危险。 为了定义在胃

幽门螺杆菌

数据表明，缺铁可增强幽门螺旋杆菌毒力，它可作为一个可测定的生物标记，用来识别具有得胃癌高风险的感染者。

胃腺癌与幽门螺旋杆菌感染强相关，但大多数被感染的人不会得胃癌。幽门螺杆菌菌株包含胞嘧啶-腺嘌呤-鸟嘌呤致病基因组（CAG +），它可以编码CagA蛋白和IV型分泌系统（T4SS），从而引发更严重的疾病。幽门螺旋杆菌感染也与缺铁性贫血相关，这同样增强患胃癌危险。

为了定义在胃癌进展中，缺铁对微生物的毒性作用，研究人员对维持缺铁的饮食并感染致癌的幽门螺旋杆菌CAG+菌株的蒙古沙鼠展开研究。研究结果显示：铁加速了幽门螺旋杆菌引起的癌前病变和恶性病变的cagA基因依赖性。采集自铁缺乏沙土鼠或生长于铁限制环境中的幽门螺杆菌菌株表现出毒力增强，可以诱导炎症因子。

与幽门螺杆菌相关的拓展阅读：


全文阅读：Iron deficiency accelerates Helicobacter pylori–induced carcinogenesis in rodents and humans



    

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    2013-08-17 xiangyuzhou971

    #EST#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2050333, encodeId=7ba52050333e1, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sat Aug 17 07:14:00 CST 2013, time=2013-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811669, encodeId=afb1181166947, content=<a href='/topic/show?id=751f8889423' target=_blank style='color:#2F92EE;'>#螺杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88894, encryptionId=751f8889423, topicName=螺杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Fri Jul 19 12:14:00 CST 2013, time=2013-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370772, encodeId=9c3713e077215, content=<a href='/topic/show?id=9c39864991e' target=_blank style='color:#2F92EE;'>#致癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86499, encryptionId=9c39864991e, topicName=致癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Fri Dec 28 07:14:00 CST 2012, time=2012-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395146, encodeId=40031395146c8, content=<a href='/topic/show?id=c268e940840' target=_blank style='color:#2F92EE;'>#缺铁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79408, encryptionId=c268e940840, topicName=缺铁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eb32500176, createdName=luckyshitiancai_42705684, createdTime=Fri Dec 28 07:14:00 CST 2012, time=2012-12-28, status=1, ipAttribution=)]
    2013-07-19 kcb069

    #螺杆菌#

    0

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    2012-12-28 jambiya

    #致癌#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2050333, encodeId=7ba52050333e1, content=<a href='/topic/show?id=95f8e042dd' target=_blank style='color:#2F92EE;'>#EST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7042, encryptionId=95f8e042dd, topicName=EST)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e9a6357, createdName=xiangyuzhou971, createdTime=Sat Aug 17 07:14:00 CST 2013, time=2013-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1811669, encodeId=afb1181166947, content=<a href='/topic/show?id=751f8889423' target=_blank style='color:#2F92EE;'>#螺杆菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88894, encryptionId=751f8889423, topicName=螺杆菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Fri Jul 19 12:14:00 CST 2013, time=2013-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1370772, encodeId=9c3713e077215, content=<a href='/topic/show?id=9c39864991e' target=_blank style='color:#2F92EE;'>#致癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86499, encryptionId=9c39864991e, topicName=致癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Fri Dec 28 07:14:00 CST 2012, time=2012-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1395146, encodeId=40031395146c8, content=<a href='/topic/show?id=c268e940840' target=_blank style='color:#2F92EE;'>#缺铁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79408, encryptionId=c268e940840, topicName=缺铁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eb32500176, createdName=luckyshitiancai_42705684, createdTime=Fri Dec 28 07:14:00 CST 2012, time=2012-12-28, status=1, ipAttribution=)]
    2012-12-28 luckyshitiancai_42705684

    #缺铁#

    0

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