Stroke:急性缺血性脑卒中的预后和每天血压变化的关系

2015-06-12 崔倩 译 MedSci原创

背景:急性缺血性脑卒中患者的血压(BP)变化与功能结果之间的关系尚不清楚。本研究旨在阐明在医院内每天的血压变化与急性缺血性卒中后功能恢复是否有关。    方法:福冈卒中注册的第一次发生缺血性脑卒中,并且在发病前在功能上独立的、24小时内入院治疗的2566例患者被纳入研究。每天测量血压,观察其变化,并通过SD、方差系数和变化独立平均值进行评估。功能预后差在3个月时通过改

背景:急性缺血性脑卒中患者的血压(BP)变化与功能结果之间的关系尚不清楚。本研究旨在阐明在医院内每天的血压变化与急性缺血性卒中后功能恢复是否有关。
    
方法:福冈卒中注册的第一次发生缺血性脑卒中,并且在发病前在功能上独立的、24小时内入院治疗的2566例患者被纳入研究。每天测量血压,观察其变化,并通过SD、方差系数和变化独立平均值进行评估。功能预后差在3个月时通过改良Rankin量表评分≥3评估。
    
结果:对多个混杂因素,包括年龄、性别、危险因素、脑卒中的特点、基线严重程度、溶栓治疗、降压药物、和平均血压调整后,在亚急性期间(发病后4天-10天)血压变化与较差的功能预后独立相关(多变量调整后的比值比[95%置信区间]在最高与最低四分位数相比收缩压变化,SD为1.51 [ 1.09-2.08 ];方差系数1.63 [1.20-2.22] ;平均变化独立性1.64 [1.21-2.24 ] )。舒张压变化也可观察到类似的趋势。这些趋势在没有服用降压药物治疗的患者中没有变化。相比之下,调整了潜在的混杂因素后在急性期血压变化指数和功能结果没有相关性。
    
结论:这些数据表明,在亚急性期间个体内每天血压变化与急性缺血性中风后3个月的功能预后相关。

原始出处:

Kenji Fukuda,Hisashi Kai,Masahiro Kamouchi,Jun Hata,et al.Day-by-Day Blood Pressure Variability and Functional Outcome After Acute Ischemic Stroke,Stroke,2015.6.11

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    2015-06-29 owlhealth

    好的

    0

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    2015-06-25 huaxipanxing

    看看

    0

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