Hypertension:成人寿命期间动脉血压、心率和脑血流动力学变化情况

2017-02-14 xing.T MedSci原创

老年与BP和CBF搏动性升高,BP、HR和CBF的连续跳动低频振荡降低以及静息时压力反射敏感性和动态脑血流自动调节受损有关。老年人在坐站动作期间升高的BP和CBF变异性表明随着老年化心血管调节能力下降,并且脑循环血流动力学应激随之增加。

年龄相关的全身和脑血流动力学改变目前还不是很清楚。近日,心血管权威杂志Hypertension上发表一篇研究文章,研究人员旨在描述在整个成人的寿命中与年龄相关的动脉血压(BP)、心率(HR)、脑血流(CBF)、心脏压力反射敏感性、动态脑血流自动调节的连续波动情况。

研究人员分析了136名健康成人,年龄在21至80岁(女性占60%)。在休息和坐站动作期间测量连续BP、HR和CBF速度来模拟体位变化对BP和CBF的影响。转化函数分析是用来评估压力反射敏感性和动态脑血流自动调节。测量颈动脉股动脉脉搏波速度以评估中心动脉硬化程度。老年与较高的颈动脉股动脉脉搏波速度、收缩压和脉搏血压、脑血管阻力、血流搏动性相关,但平均血流速度降低。与中青年相比,在休息时老年人在低频范围内连续BP、HR和CBF变异性较低,但在坐站动作期间BP和CBF的变异性较高。压力反射敏感性降低,而动态脑血流自动调节增益在休息的老年人中明显升高。多元线性回归分析表明,收缩压变异性独立于HR变异性与颈动脉股动脉脉搏波速度呈正相关。

总之,老年与BP和CBF搏动性升高,BP、HR和CBF的连续跳动低频振荡降低以及静息时压力反射敏感性和动态脑血流自动调节受损有关。老年人在坐站动作期间升高的BP和CBF变异性表明随着老年化心血管调节能力下降,并且脑循环血流动力学应激随之增加。

原始出处:

Chang-Yang Xing, et al. Arterial Pressure, Heart Rate, and Cerebral Hemodynamics Across the Adult Life Span
. Hypertension. 2017.  https://doi.org/10.1161/HYPERTENSIONAHA.116.08986

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    2017-02-15 虈亣靌

    好东西大家一起学!

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